![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by linkadge on July 10, 2011, at 21:03:09
The fatty acid amide oleamide is a highly psychoactive compound. It is formed from oleic acid (omega-9?).
Anyhow, in a basic google search oleamide interacts with cannabanoid cb1, 5-ht1a, 5-ht2c, 5-ht7 and benzodaizapine receptors.
What would be better for anxiety than a combined cannabanoid / serotonin / benzodazapine receptor agonist?
Linkadge
Posted by linkadge on July 10, 2011, at 22:05:43
In reply to oleamide for anxious depression?, posted by linkadge on July 10, 2011, at 21:03:09
Soy apparently contains several substances like genestein which are potent inhibitors of FAAH. You could combine soy with olive oil to get a natural boost of oleamide and/or anandamide signaling.
Linkadge
Posted by Phillipa on July 10, 2011, at 23:34:41
In reply to Re: oleamide for anxious depression?, posted by linkadge on July 10, 2011, at 22:05:43
Link you definitely are way beyond by level of knowledge will be interested to see what others have to say. Phillipa
Posted by torrid on July 11, 2011, at 15:53:45
In reply to oleamide for anxious depression?, posted by linkadge on July 10, 2011, at 21:03:09
I'm interested in fatty acids to help myself remain stable. I'm eating salmon and walnuts, and switched to greap seed oil for cooking. I'm going to buy virgin cold pressed greap seed oil for uncooked foods like salids. I add oil and flax seed to my breakfast drinks, virgin cold pressed will be good for there too.
Posted by BrainDamage on July 13, 2011, at 5:50:15
In reply to Re: oleamide for anxious depression? » linkadge, posted by torrid on July 11, 2011, at 15:53:45
I am in the dubious position of having tried a legal Cannabis substitute, which contained Oleamide
The substitute was very soothing & sedating, I think that this was because it contained Oleamide
Posted by BrainDamage on July 13, 2011, at 5:52:45
In reply to Re: oleamide for anxious depression?, posted by linkadge on July 10, 2011, at 22:05:43
I should have added that I would like to try pure Oleamide orally
I think that this is a very interesting substance
I would imagine that it would cause extreme sleepiness as well as anxiety relief......
Posted by europerep on July 13, 2011, at 8:52:38
In reply to Re: oleamide for anxious depression?, posted by BrainDamage on July 13, 2011, at 5:52:45
I guess one qustion would be the relative strength of the different mechanisms of action. If it has strong effects on CB but rather weak effects on 5HT and GABA, a dosage that is effective at 5HT and GABA might be too psychoactive, and it might even be anxiogenic due to strong cannabinoid activity.
Nonetheless, it's a very interesting compound I had never heard of.
Posted by BrainDamage on July 13, 2011, at 9:59:48
In reply to Re: oleamide for anxious depression?, posted by europerep on July 13, 2011, at 8:52:38
> "it might even be anxiogenic due to strong cannabinoid activity."
Speaking for Myself, Canniboids do not tend to make me anxious, they either help anxiety, or don't really effect it.
People either respond well to Canniboids, or if they respond badly, you/they soon know it!Cannabidiol is I believe a Canniboid & its has Antispychotic & Anti-anxiety properties.........
Posted by linkadge on July 13, 2011, at 14:17:01
In reply to Re: oleamide for anxious depression?, posted by BrainDamage on July 13, 2011, at 9:59:48
I think the effect of cannabis on anxiety is 'U' shaped. Lower activation increases hippocampal serotonin / norepinephrine release and decreases anxiety. Higher doses have a more anxiogenic effect also increasing locomotor hyperactivity.
The interesting thing about oleamide, is that it actually inhibits FAAH itself, meaning that it might inhibit its own metabolism and/or become more potent after chronic administration.
I am going to pick up some soy (which as I mentioned contains a few substances which inhibit FAAH). The combination of cocoa, soy and olive oil might be interesting.
Sleep is always a big issue for me. I'm hoping to find something as effective as amitriptyline for sleep with fewer side effects.
Linkadge
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.