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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by Defective on July 4, 2011, at 18:26:50
Hi, I'm currently on 100 mg of Parnate and I've worked my way up to this dose over a period of 8 weeks without a consistent benefit. I've had a few days along the way where I felt better, but nothing sustained.I didn't reach 100 until a week ago, but I still haven't noticed much of a response. Has anyone been this high? How did you feel? Did you decide to go higher? If so what happened.
Best,
Defective
Posted by jono_in_adelaide on July 4, 2011, at 19:38:17
In reply to Parnate 100 MG, posted by Defective on July 4, 2011, at 18:26:50
I'd stick with the 100mg dose for 6 weeks before you decide that it isnt working, give it a decent chance.
You could also try boosting it with desipramine or nortriptyline
Posted by Defective on July 4, 2011, at 20:00:10
In reply to Re: Parnate 100 MG, posted by jono_in_adelaide on July 4, 2011, at 19:38:17
> I'd stick with the 100mg dose for 6 weeks before you decide that it isnt working, give it a decent chance.
>
> You could also try boosting it with desipramine or nortriptylineThank you so much. What experience have you had with Parnate in the past?
Posted by jono_in_adelaide on July 4, 2011, at 22:39:06
In reply to Re: Parnate 100 MG, posted by Defective on July 4, 2011, at 20:00:10
I've never taken Parnate, but I have used many other AD's while trying to find the right one for me, and I have done some research on MAOI's when I was looking for what might work for me (in the end, Reboxetine and Sertraline taken togetehr were my magic bullet)
Some doctors would baulk at giving a tricyclic as well as Parnate, but it is quite safe - read Dr Ken Gimmores site, "Psychotropical" and send him a message, he is very helpful with info on this subject.
Posted by Defective on July 5, 2011, at 0:47:52
In reply to Re: Parnate 100 MG, posted by jono_in_adelaide on July 4, 2011, at 22:39:06
Thanks for the advice. I will definitely check that out.
Posted by Conundrum on July 5, 2011, at 10:01:00
In reply to Re: Parnate 100 MG, posted by jono_in_adelaide on July 4, 2011, at 22:39:06
> I've never taken Parnate, but I have used many other AD's while trying to find the right one for me, and I have done some research on MAOI's when I was looking for what might work for me (in the end, Reboxetine and Sertraline taken togetehr were my magic bullet)
>
> Some doctors would baulk at giving a tricyclic as well as Parnate, but it is quite safe - read Dr Ken Gimmores site, "Psychotropical" and send him a message, he is very helpful with info on this subject.Off Topic, but did you take zoloft first and then add reboxetine or start them both at the same time. What does reboxetine do for you, if you can seperate the effects.
Posted by jono_in_adelaide on July 5, 2011, at 17:59:55
In reply to Re: Parnate 100 MG, posted by Conundrum on July 5, 2011, at 10:01:00
Yes, started on Zoloft first, and added reboxetine later due to inadequate response.
Reboxetine helps lift the fog of depression, it is responsible for most of my antideprest response, Zoloft doesnt seem to do much, but my shrink seems to think that if you need Xanax (which I do) you also need an SSRI. I guess the Zoloft gives the edronax some extra kick in depression, and helps the panic attacks to some degree, but it needs the boosting effect of the Edronax/reboxetine to give me a robust response.
Posted by vicmak on July 6, 2011, at 4:33:55
In reply to Parnate 100 MG, posted by Defective on July 4, 2011, at 18:26:50
> Hi, I'm currently on 100 mg of Parnate and I've worked my way up to this dose over a period of 8 weeks without a consistent benefit. I've had a few days along the way where I felt better, but nothing sustained.I didn't reach 100 until a week ago, but I still haven't noticed much of a response. Has anyone been this high? How did you feel? Did you decide to go higher? If so what happened.
>
> Best,
>
> DefectiveHey I have been on Parnate 80mg for 8 weeks now and have only had one or two days were I felt better as well. Recently I have added wellbutrin 300mg, Salmon oil and Vitamin B complex just trying my best to get this to work because i had high hopes for parnate after trying so many other meds that did nothing for my depression or SA
Posted by bleauberry on July 6, 2011, at 18:51:18
In reply to Parnate 100 MG, posted by Defective on July 4, 2011, at 18:26:50
Sometimes the brain adaptations we want to happen take longer than anticipated. Sometimes it takes 6 to 8 weeks at a particular dose for changes to become evident and things more stable. Sometimes 12 weeks for the stronger effect. 16 weeks even better. That's the general trend of longterm AD studies anyway.
If it were me I would probably just hang on and give it at least 2 weeks at the current dose. If that didn't show any hint of anything, then I would increase the dose. I say that because there are people who only respond to higher than normal doses of parnate. I've heard of 150mg before and I'm sure others here have heard of ultra high doses. I think in most cases those high doses would cause intolerable side effects with most people. But if you are doing ok with side effects, then that should be manageable.
More time, and then more dose if needed. That's what I would do. We're all different.
Posted by Defective on July 7, 2011, at 11:53:09
In reply to Re: Parnate 100 MG, posted by bleauberry on July 6, 2011, at 18:51:18
Hey Bleau Berry, I thought my Psychiatrist was just trying to take my money by stretching out the duration of my treatment with him at first, but after exploring my alma mater's electronic database, I did discover several long-term studies for SSRI's, but none for Parnate. However, Vickmack, the poster above, informed me that he is being treated very similar to the way I have been. I'm not sure if my psychiatrist is willing to go up any higher, but he is certainly open to augmentation. I've learned to just give in and trust him. He went to Harvard for undergrad and Yale for med school, so I'm sure he knows what he's talking about, but he has never been a patient and that changes things a little. Thanks so much for helping.
Best,
Justin
Posted by Defective on July 7, 2011, at 12:06:52
In reply to Re: Parnate 100 MG, posted by vicmak on July 6, 2011, at 4:33:55
Hey Vicmack, I thought i had responded to you a couple of days ago, but I probably never hit "submit." It's great to hear from someone in my exact situation. Let's keep in touch since our situations are identical.Are you depressed or bipolar? How long have you been on the Wellbutrin for? My doctor is trying that on me in the next couple of weeks. In my experience, and I'm not a doctor or a nutritionist, vitamins or fish oils aren't going to help for depression. I say that because I've tried all of them and I'd rather you save the money. I have tried every ssri, snri, and every augmentation strategy and nothing workedd. The only MAOI that I've tried is Parnate and my doctor thinks it would be foolish to just switch to Nardil. I hope to hear from you soon. If you want we can figure out a way to exchange emails, but I'd rather not put mine on the board just in case my employer Google's me one day and thinks I'm crazy or something.
Best,
Defective
Posted by vicmak on July 7, 2011, at 22:28:53
In reply to Re: Parnate 100 MG » vicmak, posted by Defective on July 7, 2011, at 12:06:52
> Hey Vicmack, I thought i had responded to you a couple of days ago, but I probably never hit "submit." It's great to hear from someone in my exact situation. Let's keep in touch since our situations are identical.Are you depressed or bipolar? How long have you been on the Wellbutrin for? My doctor is trying that on me in the next couple of weeks. In my experience, and I'm not a doctor or a nutritionist, vitamins or fish oils aren't going to help for depression. I say that because I've tried all of them and I'd rather you save the money. I have tried every ssri, snri, and every augmentation strategy and nothing workedd. The only MAOI that I've tried is Parnate and my doctor thinks it would be foolish to just switch to Nardil. I hope to hear from you soon. If you want we can figure out a way to exchange emails, but I'd rather not put mine on the board just in case my employer Google's me one day and thinks I'm crazy or something.
>
> Best,
>
> DefectiveHey Defective
Yes it is great to find someone in pretty much the same situation! I am on Parnate for depression and Social Phobia. I really lack energy or interest for anything and just feel really hopeless. Parnate was meant to be the " magic bullet " and I did get my hopes up but I really doubt it's going to do anything after this long. I have read so many peoples experiences with it and how at the start some people would get little "highs" after taking there dose and most people had a AD effect in the in the 1-3 week mark. I only came across one guy who said it took more then 8 weeks to work but he was suffering a lot of side effects and building his dose up super slow.
I stopped the wellbutrin yesterday after 3 weeks because i ran out and it's kind of annoying to get another script as my Parnate doctor wouldn't augment so I had to go behind his back.
Like you I have tried a lot of meds. Only the TCA's i haven't been able to get my hands on. I would have liked to mix parnate and a TCA to be honest.
Have you had any more good days yet ?
Blakey@aanet.com.au
Posted by jono_in_adelaide on July 8, 2011, at 0:14:48
In reply to Re: Parnate 100 MG, posted by vicmak on July 7, 2011, at 22:28:53
As a last resort, mixing Parnate with either nortriptyline or desipramine is a great idea.
You have little to lose and much to gain by trying.
I wouldnt do it behind your doctors back though, the combination needs close monitoring etc.
You could take whatever dose of Parnate you're on, and augment with say 75-100mg of Nortriptyline at bedtime. Give this 8 weeks before you decide wether its a sucsess or failiure
Posted by bleauberry on July 8, 2011, at 4:32:52
In reply to Re: Parnate 100 MG » bleauberry, posted by Defective on July 7, 2011, at 11:53:09
Just dig up any information you can find in the archives of this board as well as google searching, and bring that info to your doctor....to show him that ultra high doses are indeed not uncommon, can work when normal doses don't, and don't seem to produce any more risk than normal doses. That to me makes a lot more sense than the augmentation merry-go-round.
But again, time, there is no substitute for time. It took a long time for our disease to settle in, and it can take time to undo it, even when on the perfect med.
> Hey Bleau Berry, I thought my Psychiatrist was just trying to take my money by stretching out the duration of my treatment with him at first, but after exploring my alma mater's electronic database, I did discover several long-term studies for SSRI's, but none for Parnate. However, Vickmack, the poster above, informed me that he is being treated very similar to the way I have been. I'm not sure if my psychiatrist is willing to go up any higher, but he is certainly open to augmentation. I've learned to just give in and trust him. He went to Harvard for undergrad and Yale for med school, so I'm sure he knows what he's talking about, but he has never been a patient and that changes things a little. Thanks so much for helping.
>
> Best,
>
> Justin
Posted by Conundrum on July 8, 2011, at 11:10:30
In reply to Re: Parnate 100 MG, posted by jono_in_adelaide on July 5, 2011, at 17:59:55
> Yes, started on Zoloft first, and added reboxetine later due to inadequate response.
>
> Reboxetine helps lift the fog of depression, it is responsible for most of my antideprest response, Zoloft doesnt seem to do much, but my shrink seems to think that if you need Xanax (which I do) you also need an SSRI. I guess the Zoloft gives the edronax some extra kick in depression, and helps the panic attacks to some degree, but it needs the boosting effect of the Edronax/reboxetine to give me a robust response.Cool thanks for the response. I wish it were available in the U.S.
Posted by Defective on July 9, 2011, at 22:47:10
In reply to Re: Parnate 100 MG » Defective, posted by bleauberry on July 8, 2011, at 4:32:52
100 mg is aready considered an ultra high dose and at this dose I've experienced hypotension that doesn't seem to be going away. With every other dose increase, the hypotension would go away within a week, but not this time. I could try convincing him to go higher, but to be honest, I'd rather not waste a ton of more time. I need to get on with my life and I feel like augmentation might be the quickest way. He said he was willing to augment with Wellutrin first, so hopefully that will help. Thanks so much for your message
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