![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by mtdewcmu on April 14, 2011, at 13:18:20
Does anyone know anything about this? This looks potentially important:
1. Neurosci Lett. 2011 Jan 20;488(2):154-7. Epub 2010 Nov 13.
Melatonin attenuates the amphetamine-induced decrease in vesicular monoamine
transporter-2 expression in postnatal rat striatum.Mukda S, Vimolratana O, Govitrapong P.
Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol
University, Salaya, Nakornpathom 73170, Thailand.The vesicular monoamine transporter-2 (VMAT-2) is responsible for packaging
intraneuronal dopamine into synaptic vesicles in preparation for synaptic release
and is a critical regulator of cytoplasmic dopamine levels and dopaminergic
function. It has long been recognized that VMAT-2 is also a critical mediator of
amphetamine-induced dopamine release. Amphetamine-induced lesions during
development have the potential to produce numerous permanent abnormalities in
neural circuitry and function. Therefore, in the present study, we investigated
the effects of amphetamine on the levels of VMAT-2, α-synuclein and
phosphorylated tyrosine hydroxylase in the striatum of neonatal rats. We found
that chronic amphetamine administration in postnatal rats produces dopaminergic
deficits in the striatum, including decreases in the levels of VMAT-2 and
phosphorylated tyrosine hydroxylase. In addition, an increase in α-synuclein
expression was observed in the striatum of postnatal rats following chronic
amphetamine treatment. Furthermore, we identified a role of (10mg/kg) melatonin,
a methoxyindole released from the pineal gland, in attenuating the detrimental
effects of amphetamine on dopaminergic neurons.
PMID: 21078367 [PubMed - in process]
Posted by poser938 on April 14, 2011, at 22:44:10
In reply to Melatonin and Amphetamine, posted by mtdewcmu on April 14, 2011, at 13:18:20
its hard for me to really understand anything right now, but im willing to try anything that might help.. and i think im going to try melatonin to help with my tolerance.. which has also caused me some major anhedonia.
Posted by mtdewcmu on April 15, 2011, at 7:42:55
In reply to Re: Melatonin and Amphetamine, posted by poser938 on April 14, 2011, at 22:44:10
> its hard for me to really understand anything right now, but im willing to try anything that might help.. and i think im going to try melatonin to help with my tolerance.. which has also caused me some major anhedonia.
To tell you the truth, I haven't read the article, yet. I've only read the abstract, so I don't know how applicable the results might be. But I couldn't get to sleep last night, and I found a bottle of melatonin in my drawer, so I'm already in effect trialing the combo. My main reservation is that melatonin is said to exacerbate depression with long-term/high-dose use. And I think even 3mg is considered a high dose.
Posted by desolationrower on May 1, 2011, at 17:44:46
In reply to Re: Melatonin and Amphetamine, posted by mtdewcmu on April 15, 2011, at 7:42:55
Usually the doses they give rats are high enough to cause damage in ways that have nothing to do with normal dosages of amp. f%#*ing war on drugs
-d/r
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.