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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on March 23, 2011, at 14:09:49
In reply to Re: L-Methylfolate Found To Work With TX RES DEPressio, posted by hansi555 on March 23, 2011, at 13:14:44
Yeah,
I'm wondering how many people would simply respond to folic acid supplementation vs. deplin.
I have been reading a bit about the so called dysfunctional gene which involves the conversion of folates to methylfolate. Apparently even if you have the dysfunctional genes, this only results in a small reduction in the ability of the body to produce methylfolate. If this is true, I would think that folic acid supplementation would also help. There are some studies showing that prozac + folic acid is better than folic acid alone. Alas, some people need a "prescription".
Linkadge
Posted by hansi555 on March 23, 2011, at 16:10:04
In reply to Re: L-Methylfolate Found To Work With TX RES DEPressio, posted by linkadge on March 23, 2011, at 14:09:49
From what I have read, the acid alone would have to be taken in huge amounts to make it equil to 7,5 mg Deplin.
I am wondering if Deplin is available in Europe?
Posted by linkadge on March 23, 2011, at 20:02:13
In reply to Re: L-Methylfolate Found To Work With TX RES DEPressio, posted by hansi555 on March 23, 2011, at 16:10:04
Not to get too pessimistic, but high folic acid levels have been associated with certain cancers.
I would personally like to use it in association with some sort of level test.
It could be working in depression as does thyroid (ie. supraphysiological levels improving depression), but this may come with adverse biological effects.
Linkadge
Posted by Phillipa on March 23, 2011, at 21:30:18
In reply to Re: L-Methylfolate Found To Work With TX RES DEPressio, posted by hansi555 on March 23, 2011, at 13:14:44
Hansi good reviews. I was on it stopped as having surgery and didn't want to scew the results of bloodwork as can effect is it B12? Maybe half a pill at first. I do know I felt nothing different when taking it before. I do have the remains of that RX probably two years old wonder if still good? Phillipa
Posted by Phillipa on March 23, 2011, at 22:11:53
In reply to Re: L-Methylfolate Found To Work With TX RES DEPressio, posted by linkadge on March 23, 2011, at 20:02:13
Link folate is given to pregnant women to help prevent neural tube defects. So where does cancer fit in not that what I said is connected to the other? Phillipa
Posted by morgan miller on March 24, 2011, at 9:20:34
In reply to Re: great news, posted by linkadge on March 22, 2011, at 16:19:36
> >Roughly 70% of patients with MDD have a specific >genetic factor that causes L-methylfolate >deficiency.
>
> Are there any large studies which show this?
>
> I noticed that you could purchase l-methylfolate in canada (1mg tabs) without a prescription. Is methylfolate available in the states OTC?
>
> LinkadgeYep, I buy it at the organic grocery store I work at(sort of a Ma and Pa Wholefoods). The Vitamin Shoppe will have it.
Posted by morgan miller on March 24, 2011, at 9:24:51
In reply to Re: L-Methylfolate Found To Work With TX RES DEPressio, posted by linkadge on March 23, 2011, at 20:02:13
>Not to get too pessimistic, but high folic acid levels have been associated with certain cancers.
Yes they have. Some over at Imminst/Longecity have theorized that the form of folic acid put in foods and supplements that needs to be converted, and as a result may not get fully absorbed. This could result in left over products that might explain the cancer causing effects. We MAY not have to worry about this as much with l-methylfolate.
Morgan
Posted by hansi555 on March 24, 2011, at 10:24:12
In reply to Re: great news, posted by linkadge on March 22, 2011, at 16:19:36
So 7,5 of this pill would do the same as one 7,5 Deplin pill:
> >Roughly 70% of patients with MDD have a specific >genetic factor that causes L-methylfolate >deficiency.
>
> Are there any large studies which show this?
>
> I noticed that you could purchase l-methylfolate in canada (1mg tabs) without a prescription. Is methylfolate available in the states OTC?
>
> Linkadge
Posted by Phillipa on March 24, 2011, at 20:31:54
In reply to Re: great news, posted by morgan miller on March 24, 2011, at 9:20:34
Morgan the Vitamin Shoppe that is where I shop. Do you take the equivalent of 7.5mg of Deplin? Notice anything good. What type of CA's noticed warnings about the B12 aplastic anemia I think it was. Phillipa
Posted by mogger on March 25, 2011, at 15:16:55
In reply to Re: great news » morgan miller, posted by Phillipa on March 24, 2011, at 20:31:54
My Psychiatrist is one of the heads at UCLA and he says it is very promising but he says Deplin is expensive. I trust him. Does anyone know what vitamin company makes the highest potency of L-Methylfolate? Thanks,
Joseph
Posted by hansi555 on March 25, 2011, at 15:50:52
In reply to Re: great news » Phillipa, posted by mogger on March 25, 2011, at 15:16:55
> My Psychiatrist is one of the heads at UCLA and he says it is very promising but he says Deplin is expensive. I trust him. Does anyone know what vitamin company makes the highest potency of L-Methylfolate? Thanks,
>
> JosephCompared to other "promising" medicines for depression, this really seems to the most really promising:
http://www.healthcentral.com/depression/c/49/16751/comments
You can get it here w/o prescription, but you would need 7,5 pills to equal one 7,5 mg Deplin pill:
Posted by mogger on March 25, 2011, at 17:05:50
In reply to Re: great news + more good reviews, posted by hansi555 on March 25, 2011, at 15:50:52
Does anyone have experience taking lower doses or does the minimum dose have to be 15mg to be effective? Thanks,
Joseph
Posted by Phillipa on March 25, 2011, at 21:31:54
In reply to Re: great news » Phillipa, posted by mogger on March 25, 2011, at 15:16:55
I don't remember what I paid for it seriously your pdoc thinks it's a good med? Did he say what he thought it would be best for treating? Thanks still have some. It couldn't have been that expensive as have medicaire? Phillipa
Posted by mogger on March 25, 2011, at 21:41:22
In reply to Re: great news » mogger, posted by Phillipa on March 25, 2011, at 21:31:54
Yes Phillipa my doctor says it is very promising. My sister and I completely trust him not only for his merits but his demeanor as has treated us both and saved our lives. He said that it is a promising adjunct to antidepressants but didn't expand on that as I was just emailing him after forwarding your excellent article. If you still have some jump on it! :)
Posted by Phillipa on March 25, 2011, at 22:02:44
In reply to Re: great news » Phillipa, posted by mogger on March 25, 2011, at 21:41:22
Mogger you shared with doc that's impressive that he feels it's a good med for ad's. Please keep me posted on anything else he/she may say on Deplin. I'd like to try it again. I forget also morning or night? I do remember one person doing extremly well on Deplin here but most others didn't. I do think Ron Hill is still using some not sure? Phillipa
Posted by mogger on March 27, 2011, at 12:39:43
In reply to Re: great news » mogger, posted by Phillipa on March 25, 2011, at 22:02:44
He just said it was to be taken once a day in the morning. I will definitely keep you updated for sure but I will really be interested to see how you feel on it!
Joseph
Posted by Phillipa on March 27, 2011, at 19:55:51
In reply to Re: great news » Phillipa, posted by mogger on March 27, 2011, at 12:39:43
I will have to find the bottle and see how many I took and then see if enough left for a fair trial. See her in about a week and a half. Don't remember any side effects though? Phillipa
Posted by mogger on March 27, 2011, at 21:07:04
In reply to Re: great news » mogger, posted by Phillipa on March 27, 2011, at 19:55:51
no side effects reported so nothing to lose.
Posted by Phillipa on March 27, 2011, at 23:59:05
In reply to Re: great news » Phillipa, posted by mogger on March 27, 2011, at 21:07:04
And can't find the Deplin. Looked so will have to wait. What is the cost? I don't remember it costing a lot. Phillipa
Posted by mogger on March 28, 2011, at 0:00:35
In reply to Re: great news » mogger, posted by Phillipa on March 27, 2011, at 23:59:05
I have no idea unfortunately.
Joseph
Posted by Phillipa on March 28, 2011, at 13:15:45
In reply to Re: great news » Phillipa, posted by mogger on March 28, 2011, at 0:00:35
Mogger I found the old RX it is three years old the pills think they are still good? I'm afraid to try them without knowing and know ask a pharmacist they will say they can't answer. Phillipa
Posted by mogger on March 28, 2011, at 13:21:01
In reply to Re: great news » mogger, posted by Phillipa on March 28, 2011, at 13:15:45
I am not sure unfortunately Phillipa. I would call your psychiatrist and ask her if they are still good and if she thinks they are too old ask her if she wouldn't mind calling you in a prescription as you are interested in trying it again. Sorry I can't be of more help,
Joseph
Posted by Phillipa on March 28, 2011, at 19:47:45
In reply to Re: great news » Phillipa, posted by mogger on March 28, 2011, at 13:21:01
That's okay I've heard the military keeps meds for years and years and uses them. Not antibiotics of course. I would hesitate if not considered a food. They look fine in air tight bottle all that time. Probably will. Too expensive looked online $230 something? Ridiculous. But since have medicaire no idea how every got a RX and paid for it? Have to check into the cost now. Thanks Joseph
Posted by mogger on March 29, 2011, at 0:29:13
In reply to Re: great news » mogger, posted by Phillipa on March 28, 2011, at 19:47:45
Good luck with it Phillipa. I am excited for you as I hope/think it will benefit you. Please keep me updated,
Joseph
Posted by Phillipa on March 29, 2011, at 19:59:21
In reply to Re: great news » Phillipa, posted by mogger on March 29, 2011, at 0:29:13
See pdoc next week will see what she says. Also did some googling and found some dicussion boards and feedback positive mostly bipolar though. But they mentioned cost as around $45.00. So no idea why the online pharmacies so high? Will keep you posted Phillipa
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