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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Tomatheus on November 30, 2010, at 22:42:29
From MedPage Today:
Tricyclics Increase CVD Risk
By Nancy Walsh, Staff Writer, MedPage Today
Published: November 30, 2010
Reviewed by Zalman S. Agus, MD; Emeritus Professor
University of Pennsylvania School of Medicine.Growing concern that patients taking tricyclic antidepressants are at increased risk for cardiovascular disease has been proven out in a large European study.
In a prospective cohort study that included 14,784 adults, those using tricyclics had a 35% increased cardiovascular risk after adjustment for potential confounders including symptoms of depression and anxiety, which are known risk factors for cardiovascular disease (HR 1.35, 95% CI 1.03 to 1.77).
In contrast, the use of selective serotonin reuptake inhibitors (SSRIs) was not associated with an elevated risk (HR 1.11, 95% CI 0.77 to 1.60), Mark Hamer, PhD, of University College London, and colleagues reported online in the European Heart Journal.
Read full article:
http://www.medpagetoday.com/Geriatrics/Depression/23662
Posted by Phillipa on December 1, 2010, at 0:38:10
In reply to Tricyclics increase CVD risk, posted by Tomatheus on November 30, 2010, at 22:42:29
Yes I've known this hence why I personally would not take them as CV disease in my family all have died of heart attacks or strokes. Thanks Phillipa
Posted by linkadge on December 1, 2010, at 7:52:31
In reply to Tricyclics increase CVD risk, posted by Tomatheus on November 30, 2010, at 22:42:29
Yeah, but it could be a reverse corelation. I know they accounted for depression, but TCA use could be a indicator of more severe depression.
Also, I don't think there is a class effect since some of the TCAs affect the heart more than others.
Linkadge
Posted by ed_uk2010 on December 1, 2010, at 11:47:24
In reply to Re: Tricyclics increase CVD risk, posted by linkadge on December 1, 2010, at 7:52:31
> Yeah, but it could be a reverse corelation. I know they accounted for depression, but TCA use could be a indicator of more severe depression.
>
> Also, I don't think there is a class effect since some of the TCAs affect the heart more than others.
>
> LinkadgeYeah, it's not proof, more of a possibility. Weight gain may be an issue. I suspect that the risk of CVD is substantially elevated by most atypical antipsychotics.
This is the end of the thread.
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