Psycho-Babble Medication Thread 966173

Shown: posts 1 to 6 of 6. This is the beginning of the thread.

 

Zofran used off-label for social anxiety?

Posted by jerryTRD on October 18, 2010, at 17:25:06

I've read online and in my Drug books that Zofran (Ondansetron) is/can be used for social anxiety disorder. I suppose this is because of it's effects on 5-HT3 receptors? But BuSpar does the same thing - why isn't it as helpful? Or am I wrong?

Jerry

 

Re: Zofran used off-label for social anxiety? » jerryTRD

Posted by Phillipa on October 18, 2010, at 18:28:25

In reply to Zofran used off-label for social anxiety?, posted by jerryTRD on October 18, 2010, at 17:25:06

Really as when had surgery the doc said to have zofran on hand and I remembered was it was used in chemo to prevent vomiting so didn't fill. Then googled it and didn't like the side effects. Is there a study? Phillipa

 

Re: Zofran used off-label for social anxiety?

Posted by jerryTRD on October 18, 2010, at 18:52:38

In reply to Zofran used off-label for social anxiety?, posted by jerryTRD on October 18, 2010, at 17:25:06

> I've read online and in my Drug books that Zofran (Ondansetron) is/can be used for social anxiety disorder. I suppose this is because of it's effects on 5-HT3 receptors? But BuSpar does the same thing - why isn't it as helpful? Or am I wrong?
>
> Jerry

Ondansetron in social phobia
by M.S. Grunes, J.A. Yaryura-Tobias, F.A. Neziroglu
Biological Psychiatry (Vol. 39, Issue 7, Page 624)

Unlabeled Uses

Treatment of nausea and vomiting associated with acetaminophen poisoning or prostacyclin therapy; treatment of acute levodopa-induced psychosis (visual hallucinations); reduction in bulimic episodes due to bulimia nervosa; treatment of spinal or epidural morphine-induced pruritus; management of social anxiety disorder.

Read more: http://www.drugs.com/ppa/ondansetron-hydrochloride.html#ixzz12l2DOFj5

 

Re: Zofran used off-label for social anxiety?

Posted by linkadge on October 18, 2010, at 19:17:46

In reply to Re: Zofran used off-label for social anxiety?, posted by jerryTRD on October 18, 2010, at 18:52:38

buspar is a 5-ht1a agonist. It has no effect on 5-ht3 that I am aware of.

Linkadge

 

Re: Zofran used off-label for social anxiety? » linkadge

Posted by jerryTRD on October 18, 2010, at 20:41:19

In reply to Re: Zofran used off-label for social anxiety?, posted by linkadge on October 18, 2010, at 19:17:46

> buspar is a 5-ht1a agonist. It has no effect on 5-ht3 that I am aware of.
>
> Linkadge


ah ok my bad. Brain f*rt.

 

Re: Zofran used off-label for social anxiety?

Posted by ed_uk2010 on October 18, 2010, at 23:23:55

In reply to Zofran used off-label for social anxiety?, posted by jerryTRD on October 18, 2010, at 17:25:06

>I've read online and in my Drug books that Zofran (Ondansetron) is/can be used for social anxiety disorder. I suppose this is because of it's effects on 5-HT3 receptors?

Hi J

I have heard of ondansetron being used for anxiety (experimentally).

Mirtazapine (Remeron) blocks 5-HT3 receptors amongst other things. That may contribute to its effects.


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