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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by SLS on July 11, 2010, at 10:38:10
Does anyone have experience with Ramelteon (Rozerem)? It has been shown to phase-shift advance circadian rhythms and possibly align them. This might indicate that ramelteon has therapeutic potential for treating depression. It would be interesting to know how combining ramelteon with mirtazapine (Remeron) would affect depression.
Any feedback would be appreciated.
- Scott
Posted by linkadge on July 11, 2010, at 15:03:52
In reply to Ramelteon (Rozerem) in Depression., posted by SLS on July 11, 2010, at 10:38:10
I have used melatonin in conjunction with mirtazapine. I would assume this is similar.
Linkadge
Posted by europerep on July 11, 2010, at 15:41:06
In reply to Ramelteon (Rozerem) in Depression., posted by SLS on July 11, 2010, at 10:38:10
> Does anyone have experience with Ramelteon (Rozerem)? It has been shown to phase-shift advance circadian rhythms and possibly align them. This might indicate that ramelteon has therapeutic potential for treating depression. It would be interesting to know how combining ramelteon with mirtazapine (Remeron) would affect depression.
>
> Any feedback would be appreciated.
>
>
> - Scott
>I see it's a MT1 and MT2 agonist... wouldn't that, combined to mirtazapine's 5HT-2C antagonism, basically resemble agomelatine?
Posted by Questionmark on July 11, 2010, at 15:49:31
In reply to Ramelteon (Rozerem) in Depression., posted by SLS on July 11, 2010, at 10:38:10
I don't understand why one would want to try this when melatonin is already available OTC and cheap.
Not being smart I'm just confused.
Agomelatine yes, but if ramelteon only as melatonin receptor agonist properties i don't understand.
> Does anyone have experience with Ramelteon (Rozerem)? It has been shown to phase-shift advance circadian rhythms and possibly align them. This might indicate that ramelteon has therapeutic potential for treating depression. It would be interesting to know how combining ramelteon with mirtazapine (Remeron) would affect depression.
>
> Any feedback would be appreciated.
>
>
> - Scott
>
>
Posted by ed_uk2010 on July 11, 2010, at 15:52:35
In reply to Re: Ramelteon (Rozerem) in Depression., posted by europerep on July 11, 2010, at 15:41:06
>I see it's a MT1 and MT2 agonist... wouldn't that, combined to mirtazapine's 5HT-2C antagonism, basically resemble agomelatine?
I think it would cause more adverse effects than agomelatine but it might be more effective.
Posted by linkadge on July 11, 2010, at 19:58:56
In reply to Re: Ramelteon (Rozerem) in Depression., posted by ed_uk2010 on July 11, 2010, at 15:52:35
There is animal research in which melatonin reduces the toxicity of certain medications.
For instance, the antioxidant effects of melatonin appear to reduce the progression of TD, at least in animal models.
Linkadge
Posted by emmanuel98 on July 11, 2010, at 20:53:40
In reply to Ramelteon (Rozerem) in Depression., posted by SLS on July 11, 2010, at 10:38:10
I took rozerem for a week to help with sleep years ago when I was withdrawing from opiates. It had absolutely no effect on me.
Posted by Ron Hill on July 16, 2010, at 3:29:51
In reply to Ramelteon (Rozerem) in Depression., posted by SLS on July 11, 2010, at 10:38:10
> Does anyone have experience with Ramelteon (Rozerem)? It has been shown to phase-shift advance circadian rhythms and possibly align them. This might indicate that ramelteon has therapeutic potential for treating depression. It would be interesting to know how combining ramelteon with mirtazapine (Remeron) would affect depression.
> Any feedback would be appreciated.
--------------------Scott, et al;
Here are two extensive lists of anecdotal responses to ramelteon. Most people hate it, and some love it:
http://www.askapatient.com/viewrating.asp?drug=21782&name=ROZEREM&sort=age&order=1
-- Ron
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