Psycho-Babble Medication Thread 952389

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endocannabinoid system in novel antidepressants

Posted by europerep on June 27, 2010, at 14:23:31

hey there...

I just found a very short article on the implication of endocannabinoids, or rather a lack thereof, in depression, and how this might be a new pathway leading to novel antidepressant treatment.
this is apparently still in very early stages, but it's by scientists from, among others, McGill and Vanderbilt..

http://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147(09)00121-7

finally the confirmation of what I have always been suspecting or what I have experienced actually.. it's sad it will take the regular time of developing a drug + the "bad receptor" delay.. seeing how long it took for thc in pain management it may actually be quite long, but maybe we are a step further today.. I sure hope so..

 

Re: endocannabinoid system in novel antidepressants

Posted by linkadge on June 27, 2010, at 19:20:25

In reply to endocannabinoid system in novel antidepressants, posted by europerep on June 27, 2010, at 14:23:31

Interesting. The TCA antidepresssants increase the activity of the endocannabanoid system. The antidepressant citalopram actually decreases it.

Linkadge

 

Re: endocannabinoid system in novel antidepressants

Posted by TenMan on June 28, 2010, at 15:33:09

In reply to Re: endocannabinoid system in novel antidepressants, posted by linkadge on June 27, 2010, at 19:20:25

Hyperforin, one of the active constituents in St. John's Wort, potently activates TRPC6 channels which when activated increase levels of endogenous endocannabinoids.

 

Re: endocannabinoid system in novel antidepressants

Posted by desolationrower on June 30, 2010, at 16:31:49

In reply to Re: endocannabinoid system in novel antidepressants, posted by TenMan on June 28, 2010, at 15:33:09

Rimonabant was a anti-obesity drug that also reduced smoking and other addictive behavior.

It causes depression though.

It is a CB1 inverse agonist.

-d/r


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