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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on May 25, 2010, at 20:26:16
Are there any available selective antihistamines? Most of the ones I can think of are strong anticholinergics or 5-ht2 blockers. A selective sedative antihistamine would be very beneficial. Sometimes they work for me when benzos don't.
Linkadge
Posted by ed_uk2010 on May 27, 2010, at 14:19:12
In reply to selective antihistamines, posted by linkadge on May 25, 2010, at 20:26:16
> Are there any available selective antihistamines?
Yes, but they are generally non-sedating because they do not cross the blood brain barrier in large amounts. Cetirizine, levocetirizine, loratadine, desloratadine and fexofenadine are all relatively selective.
Among the sedating antihistamines, hydroxyzine seems to cause fewer anticholinergic side effects than diphenhydramine or promethazine.
Have you tried hydroxyzine? Take 25mg and see if you feel calmer.
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