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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 41. This is the beginning of the thread.
Posted by Franz on May 26, 2010, at 10:52:49
I was considering trying an SSRI but this scared me.
Permanent sexual dysfunction?. Is this real?
Post-SSRI sexual dysfunction
http://en.wikipedia.org/wiki/Post-SSRI_sexual_dysfunctionAntidepressants Do Cause Permanent Sexual Dysfunction
http://www.youtube.com/watch?v=9-6pmsVOe3g
Posted by manic666 on May 26, 2010, at 12:34:26
In reply to Post-SSRI permanent sexual dysfunction? Real?, posted by Franz on May 26, 2010, at 10:52:49
eeeeeeeeer NO, some really mess with your sex life thats true//but so do most meds//if you have a low sex drive to start with ,its bad news //but i dont have any real prob,s on 100mg of sertraline//celexa yes i do,but another patient may be different///its fair to say when ajusting it seem,s you lose your mojo//but mainly it return,s depends on the amount of meds your on//you may get delay on the ejacalation side//but that may cool for your partner//the only way to find out is to try ssri,s yourself as we are all different.//i think in my 20tis no matter how many ssris i took you would still have to beat my pork sword with a stick to make it lie down.
Posted by Phillipa on May 26, 2010, at 12:43:28
In reply to Re: Post-SSRI permanent sexual dysfunction? Real?, posted by manic666 on May 26, 2010, at 12:34:26
Young more hormones. Phillipa
Posted by manic666 on May 26, 2010, at 12:45:16
In reply to Re: Post-SSRI permanent sexual dysfunction? Real? » manic666, posted by Phillipa on May 26, 2010, at 12:43:28
no just manic the sex god
Posted by Franz on May 26, 2010, at 13:42:40
In reply to Post-SSRI permanent sexual dysfunction? Real?, posted by Franz on May 26, 2010, at 10:52:49
Thanks
I should have searched there is athread from 2009
http://www.dr-bob.org/babble/20090818/msgs/913953.htmlAnyway, this is scary and if anyone have recent info I would like to know.
Maybe a way to minimize risk is to stop medication if it causes sexual dysfunction while on it?. Or is this too frequent?.
Posted by bulldog2 on May 26, 2010, at 16:21:50
In reply to Post-SSRI permanent sexual dysfunction? Real?, posted by Franz on May 26, 2010, at 10:52:49
> I was considering trying an SSRI but this scared me.
>
> Permanent sexual dysfunction?. Is this real?
>
> Post-SSRI sexual dysfunction
> http://en.wikipedia.org/wiki/Post-SSRI_sexual_dysfunction
>
> Antidepressants Do Cause Permanent Sexual Dysfunction
> http://www.youtube.com/watch?v=9-6pmsVOe3gif you stopped right away it would be very unlikely it would be permanant.
Posted by linkadge on May 26, 2010, at 16:25:48
In reply to Re: Post-SSRI permanent sexual dysfunction? Real?, posted by bulldog2 on May 26, 2010, at 16:21:50
They can. Not everybody gets this side effect but it is possible.
Linkadge
Posted by bearfan on May 26, 2010, at 16:53:01
In reply to Re: Post-SSRI permanent sexual dysfunction? Real?, posted by linkadge on May 26, 2010, at 16:25:48
I've heard some real reports of this (mostly long term users), but depression itself can cause SD, so it can be hard to quantify. If your taking an SSRI for 6 months to a year, and then discontinue, this most likely won't be the case (although you may experience SD during treatment).
Posted by Conundrum on May 26, 2010, at 22:03:08
In reply to Post-SSRI permanent sexual dysfunction? Real?, posted by Franz on May 26, 2010, at 10:52:49
Its my experience and the experiences of others I know that SSRIs do numb up the feelings down there. The best way to avoid this is to not take them if you really don't need to be on an antidepressant. Have you tried therapy? If you you need an antidepressant you could try Wellbutrin, or Nefazodone. Nefazodone is only available in the US, there is a very small risk of liver failure with nefazodone. I guess you could get tianeptine if you are in a country that has that available, it shouldn't cause any sexual dysfunction. You could also try mirtazapine, but I don't know how easy that would be to get unless you are really thin or have trouble sleeping. If you had to try an SSRI I would think prozac would be your safest bet for not causing sexual dysfunction. I found the SNRI Pristiq enhanced sensation for a little while, but then felt dull. I'm super sensitive to serotonin though. You might be different.
I think of all the ideas I've listed Wellbutrin is your best bet, unless you've already tried that and it didn't work. If you just have anxiety you might consider taking a benzo.
Posted by manic666 on May 27, 2010, at 3:23:11
In reply to Re: Post-SSRI permanent sexual dysfunction? Real? » Franz, posted by Conundrum on May 26, 2010, at 22:03:08
the meds will change you, so sex may not be top of the list of must do today///as you get used to a med things start to return //not to normal but mabye close///depends on your age as well you my be on choslesterol tabs //thyriod tabs, benzo,s they all take there toll on the trouser snake///guys have it both ways,no erection an no orgasm//with the ladies at least the can have sex with there partner ,even if no orgasm//worry about it makes it worse//i have never took viagra so there is a plus //but if there is a problem why not try them.//
Posted by SammyJar on May 27, 2010, at 3:57:02
In reply to Post-SSRI permanent sexual dysfunction? Real?, posted by Franz on May 26, 2010, at 10:52:49
I am on 20mg. generic Paxil and 300mg. of brand name Wellbutrin XL, and have had all the described sexual dysfunction from my first dose of Paxil. No desire, numbness, pretty much impossible to have an orgasm. The Wellbutrin doesn't seem to help at all even though it did increase my libido when I first went on it by itself(although that seemed to fade after a couple of weeks). I have only been on Paxil for 3 weeks, but this is worrying since Paxil has pretty much shut me down sexually. When someone is more prone to the sexual side effects of these SSRI's do you think it would increase the chance of permanent problems? The Wellbutrin gives me too much anxiety(especially at night) without the Paxil. Now I don't know if I should continue with it or not. It is helping a little.I also take Xanax and Inderal as needed, but I have been taking them for quite awhile, and they have never caused any sexual problems for me.
Posted by Conundrum on May 27, 2010, at 7:55:42
In reply to Re: Post-SSRI permanent sexual dysfunction? Real?, posted by SammyJar on May 27, 2010, at 3:57:02
> When someone is more prone to the sexual side effects of these SSRI's do you think it would increase the chance of permanent problems?
I think it would more than someone who doesn't have this problem.
>Now I don't know if I should continue with it or not. It is helping a little.
Thats something you really have to be careful evaluating. I've seen a lot of people here say they don't think the drug is helping that much and then they stay off it for some months and realize how much it had helped them. You really have to be honest with yourself about that. IMO paxil is one of the biggest offenders in this area. You might wanna try prozac or zoloft at the lowest needed dose. Like I mentioned before I found pristiq to increase sexual sensitivity, but not everyone experiences this. Don't forget about mirtazapine. Some people and docs say to forget about the sexual side effects, if it is helping. I can see where these people are coming from, that we should be grateful that we are no longer miserable. But the lack of sex drive can destroy relationships or make them very difficult. It might be tolerable if you planned on being single the rest of your life, but that would make most people miserable anyway. Also I would watch out for emotional numbing as well. Paxil is known for that in some folks. Some say thats how it works, by blocking emotions, but once you become a zombie thats a problem.
>
> I also take Xanax and Inderal as needed, but I have been taking them for quite awhile, and they have never caused any sexual problems for me.
Posted by manic666 on May 27, 2010, at 13:44:38
In reply to Re: Post-SSRI permanent sexual dysfunction? Real?, posted by manic666 on May 26, 2010, at 12:45:16
i think there can be trouble with partner,s// if you are a guy or a woman an were the dominant one in bed// i dont mean dominant as in sadistic but the one who usally starts the forplay//an you have lost your sex drive//,sometimes your partner is lost and dont no how to respond an step,s back an wait,s //thinking he or she will be cool soon// my wife is a bit this way ,always up for sex but wants me to the one to make the move//something a lot of people have //they fear you may reject them ,so they tend to wait for a sign from there partner first// this can cause the problem to be worse as you fear you may not be up to the job, an then its a no win situation//then there is the other way round they may make more effort an then its you who feels weird as the rolls reverse an you back off..jesus its bad when you put it to paper
Posted by manic666 on May 30, 2010, at 11:25:11
In reply to Re: Post-SSRI permanent sexual dysfunction? Real?, posted by manic666 on May 27, 2010, at 13:44:38
no replies on my answer //come on it must happen to other than me//the med is the mojo killer //but there is more to it than that//your confedence takes a knock//your partner may not help enough //so another knock an so on an so on//its starts with the med, but that my pass ,an your out the loop //an swimming out to sea an not the shore
Posted by lpslpslpslpslpslps on June 5, 2010, at 22:00:44
In reply to Re: Post-SSRI permanent sexual dysfunction? Real?, posted by manic666 on May 30, 2010, at 11:25:11
You could always try Dostinex (cabergoline). In some people it dramatically enhances libido, arousal, orgasm quality, and it also decreases the refractory period, at least anecdotally.
Posted by manic 666 on June 6, 2010, at 9:25:52
In reply to Re: Post-SSRI permanent sexual dysfunction? Real?, posted by lpslpslpslpslpslps on June 5, 2010, at 22:00:44
i no all about supliments thats not the issue hear//its attitude to changeing sex thoughts on meds//you partner could adapt to the change an help more///not just hope you get your mojo back sharpish// so i will wait ,,if it was just all down to the meds, we would top up on vigra
Posted by sukarno on June 7, 2010, at 12:50:18
In reply to Re: Post-SSRI permanent sexual dysfunction? Real?, posted by manic 666 on June 6, 2010, at 9:25:52
There is a Yahoo group consisting of hundreds of people, albeit anecdotal accounts, with this syndrome.
I suppose pramipexole or ropinirole could be useful (and safer) since ergot derivatives can cause fibrosis in the heart and lungs.
Posted by Brainbeard on June 10, 2010, at 6:50:37
In reply to Re: Post-SSRI permanent sexual dysfunction? Real?, posted by sukarno on June 7, 2010, at 12:50:18
Posted by manic666 on June 10, 2010, at 7:39:33
In reply to Yep. SSRI's may be worse for the brain than XTC. (nm), posted by Brainbeard on June 10, 2010, at 6:50:37
Posted by Conundrum on June 10, 2010, at 9:24:02
In reply to Yep. SSRI's may be worse for the brain than XTC. (nm), posted by Brainbeard on June 10, 2010, at 6:50:37
Posted by Brainbeard on June 10, 2010, at 15:28:18
In reply to brainbeard a wealth of imformation /// thanks (nm), posted by manic666 on June 10, 2010, at 7:39:33
Posted by violette on June 11, 2010, at 2:36:54
In reply to Yep. SSRI's may be worse for the brain than XTC. (nm), posted by Brainbeard on June 10, 2010, at 6:50:37
Brainbeard - would you mind sharing how SSRIs cause damage to the brain????
Posted by Brainbeard on June 11, 2010, at 9:57:46
In reply to Re: Yep. SSRI's may be worse for the brain than XTC. » Brainbeard, posted by violette on June 11, 2010, at 2:36:54
> Brainbeard - would you mind sharing how SSRIs cause damage to the brain????
Animal studies have shown that SSRI's produce morphological changes in several brain regions after a couple of days of high doses. That is to say, they deform certain parts of the brain. Reseachers saw marked changes in nerve terminals which release serotonin, and they saw cells that shriveled or took on abnormal corkscrew shapes. Moreover, the brain cell changes with SSRIs were similar to those observed with MDMA (XTC).
Now, we don't know wether the same holds true for humans. "We don't know if results with four days of drug treatment are clinically significant," says Madhu Kalia, the professor at Jefferson Medical College of Thomas Jefferson University in Philadelphia who led the study. "We don't know if the cells are dying. That's the key question. We need to do more studies to prove cell death. These effects may be transient and reversible. Or they may be permanent."
Well, apparently noone is interested in funding these studies - they would be very costly and where does the money for pharmacological research usually come from? Yep, from the pharmaceutical industry. What interest would Big Pharma have in funding studies that would show SSRI's to be neurotoxic?
Although scientifically, we don't know wether SSRI's cause permanent or long-lasting brain damage, in real life there are lots of clues that point to temporary or permanent brain damage. One such clue is the often persistant sexual dysfunction and lowered libido experienced even years after SSRI use. Post-SSRI sexual dysfunction and other problems are being discussed here on Babble extensively.
Links to the study:
Popular:
http://www.scienceblog.com/community/older/2000/D/200003824.html
Scientific:
Manic, I hope this overload of information is not lethal. ;)
Posted by Conundrum on June 11, 2010, at 10:10:07
In reply to Why SSRI's may be AS BAD for the brain as XTC, posted by Brainbeard on June 11, 2010, at 9:57:46
I thought MDMA often causes over heating and even death especially in clubs where people might not be keeping hyrdrated.
I think it does cause permanent changes. Here I am 7 years after taking and SSRI with permanent changes including anhedonia, poor concentration, poor memory, change in libido, joint pain, and bad dreams.
Taking an SSRI forces the brain to make adaptive changes, but discontinuing the drug doesn't seem to give the brain any impetus to change back to baseline.
Posted by chujoe on June 11, 2010, at 11:21:04
In reply to Re: Why SSRI's may be AS BAD for the brain as XTC » Brainbeard, posted by Conundrum on June 11, 2010, at 10:10:07
>>Here I am 7 years after taking and SSRI with permanent changes including anhedonia, poor concentration, poor memory, change in libido, joint pain, and bad dreams.<<
I'm not doubting your experience, but I don't think you can make a very strong case for the SSRI leading necessarily to the conditions & symptoms you describe. As a counter example, ten years ago I had a manic episode with very high levels of anxiety, intrusive thinking, and other frightening symptoms. I was treated with an SSRI and recovered. After a couple of years I discontinued the drug and went along happily for another seven years of so, until, last summer, I had another episode of crazy anxiety and depression. I was put on an SSRI, which was only partly effective, so I switched to an SNRI, which has worked very well.
Now, it's possible of course that the SSRI damaged my brain in some way and perhaps even contributed to the second episode, but it's very difficult to make that case because of the long period of normal functioning. (I also had symptoms long before I ever tried an SSRI.) And maybe I am damaging my brain now, but I'm not willing to go back to the way I felt last summer.
Do SSRIs only damage some people's brains? What is the nature of the damage? Is all change in brain anatomy & function to be considered damage? Our brains change in response to many things -- food, psychological stress, learning, drugs, environmental factors, etc. Do SSRIs have a particularly dangerous effect on the brain? Can you be certain you wouldn't have the symptoms you have now if you had not taken an SSRI?
Conundrum, I'm not trying to be confrontational, nor do I believe psych drugs are a panacea; but I think blanket statements about whole classes of drugs are very hard to support, either logically, or on the basis of clinical evidence.
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