![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by pedr on April 18, 2010, at 23:20:33
I found this easy to read and yet pretty informative, especially the article explaining why tyramine is problematic.
http://thecarlatreport.com/issue/vol4-no11
Pete
Posted by Sigismund on April 18, 2010, at 23:35:52
In reply to FYI: nice intro to MAOI's, posted by pedr on April 18, 2010, at 23:20:33
This was interesting....
>The scoop on Marplan is that it is better tolerated than Nardil, and a large meta-analysis reported that it has outperformed placebo more robustly than Parnate or Nardil (Thase et. al., Neuropsychopharmacology 1995;12:185-219).
Posted by SLS on April 19, 2010, at 7:10:39
In reply to FYI: nice intro to MAOI's, posted by pedr on April 18, 2010, at 23:20:33
> I found this easy to read and yet pretty informative, especially the article explaining why tyramine is problematic.
>
> http://thecarlatreport.com/issue/vol4-no11
>
> Pete
Nice article.
- Scott
Posted by pedr on April 19, 2010, at 11:43:45
In reply to Re: FYI: nice intro to MAOI's » pedr, posted by Sigismund on April 18, 2010, at 23:35:52
> This was interesting....
>
> >The scoop on Marplan is that it is better tolerated than Nardil, and a large meta-analysis reported that it has outperformed placebo more robustly than Parnate or Nardil (Thase et. al., Neuropsychopharmacology 1995;12:185-219).
>absolutely interesting. When I crash badly, one of my main worries is that Nardil is "the end of the road" in terms of meds. I hadn't really considered other MAOI's. Especially the bit about his patient who only repsonded to Marplan and has stayed well for many years. Makes me wonder why Marplan is so uncommon.
Posted by sigismund on April 20, 2010, at 17:45:15
In reply to Re: FYI: nice intro to MAOI's » Sigismund, posted by pedr on April 19, 2010, at 11:43:45
>Makes me wonder why Marplan is so uncommon.
Yes, AFAIK it is not available in Australia any more, though of course it could be imported.
The doctors I know are so sceptical about ADs that they would be just as comfortable with Marplan as anything else.
Posted by stargazer2 on April 21, 2010, at 11:35:45
In reply to Re: FYI: nice intro to MAOI's » Sigismund, posted by pedr on April 19, 2010, at 11:43:45
I took Marplan very successfully until it was discontinued in the late 90's, so everyone on Marplan had to get off (Good luck) and try and find another med that would work for them. I never found one as successful as Marplan.
From when Marplan was discontinued through the last few years, I essentially was a guinea pig and tried hundreds of meds in combination and alone with very little success. Years were lost to drug trials with no real long term success. Marplan probably worked for a few years at the time it was eliminated. I was devastated and hardly recovered from that situation.
So that is why Marplan might be underutilized today. I informed my doc of it's release again in 2003 and I tried it a year or two after that without success. Unfortunately, as it had been very efficacious for me, allowing me to keep a job for 7 years (my longest ever). I crashed and burned big time, losing my mental stability and the job. Double whammy!
That is the dilemma with meds working once and never again. It is very common.
I think the new version of Marplan is not the same formula, same as what happened to Nardil after it's reformulation. Never will know as I would love there to be more on Marplan here to test its usefulness. I was on Marplan as a monotherapy with relief of all symptoms I had.
It was an amazing med and NArdil is it's successor.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.