Shown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by bulldog2 on February 18, 2010, at 9:35:30
I have noticed that I feel an exaggerated response to pain when I am depressed. Others on this forum have also complained of pain when in a state of depression.
Would this seem to indicate that some depressed people have a shortage of endogenous endorphins while depressed?
Posted by Phillipa on February 18, 2010, at 10:56:17
In reply to Depression,Pain and Opiates, posted by bulldog2 on February 18, 2010, at 9:35:30
Could be pain leads to depression or depression leads to pain as they go together. What do you feel? Phillipa
Posted by floatingbridge on February 18, 2010, at 17:00:09
In reply to Depression,Pain and Opiates, posted by bulldog2 on February 18, 2010, at 9:35:30
Bulldog,
Seems possible for some, hence, possibly, why LDN works in some cases.
My pdoc says ptsd changes pain sensitivity, perhaps in my case, increasing response.
I did come across a patent site (Isreal) that was working on a transdermal subnoxone (sp!) for trd and chronic pain...
Posted by linkadge on February 18, 2010, at 21:12:05
In reply to Re: Depression,Pain and Opiates » bulldog2, posted by floatingbridge on February 18, 2010, at 17:00:09
There has been a bit of recent research into the effects of the opiate system in depression.
Many antidepressants have indirect effects on the opioid system. As you probably know, drugs with norepinephrine reuptake capacity (ixel, duloxetine, venlafaxine, TCA's) are often used in pain management. The analgesic effects of NRI's is not shared by the SSRI's. NRI's appear to have some ability to prolong the analgesia of certain opioid compounds.
TCA's have other direct effects on the opioid system. Many of the TCA's have effects on the delta opioid system. Delta opioid agonists have antidepressant effects. Kappa opioid receptors are another opoiod receptor although in this case it is kappa antagonists that have antidepressant effects. Kappa agonists like dynorphin and salvorin have depressant effects, but they appear to have anti-addiction, anticonvulsant and and analgesic effects.
ECT appears to increase the expression of opoid receptors. Exercise increases endorphin levels.
MU opioid receptors have potent antidepresant and analgesic effects, but tollerance is an issue.
Linkadge
Posted by Phillipa on February 18, 2010, at 21:26:27
In reply to Re: Depression,Pain and Opiates, posted by linkadge on February 18, 2010, at 21:12:05
Link any idea why when cymbalta first out could take 60mg, excercised at the gym lifting weights machine ones and walked five miles on the beach without pain? Stopped the med with no problem went back to standby luvox and viola had backpain. Moved here and the pdoc didn't like him put me on cymbalta 30 one week, 60, 90, 120mg for a month. I never got past 30mg as I couldn't tolerate it now. Boy this pdoc scared me 20minutes for first session and his psych testing guy kept telling me benzos were depressing and they hadn't depressed me in all the years I took them. I went off cymbalta after about 7 days the anxiety and pure fear were too much? Why react so differently the second time? Phillipa
This is the end of the thread.
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