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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by ColoradoSnowflake on January 24, 2010, at 22:27:13
Hi Everybody:
I'm down to 30mg/day Parnate (plus 150mg Provigil and 5mg Nortriptyline). Side effects all lessening.
I'd like to try DLPA but remember seeing something about phenylalynine (sp?) being a no-no with Parnate? I'm not planning on coming totally off Parnate if I can help it.
Do any of you guys know??
Thanks,
Posted by Phillipa on January 24, 2010, at 23:43:58
In reply to Is DLPA OK with Parnate??, posted by ColoradoSnowflake on January 24, 2010, at 22:27:13
I don't just had to say hi and missed you and hoping your're feeling much better. Love Phillipa
Posted by bulldog2 on January 25, 2010, at 9:09:20
In reply to Is DLPA OK with Parnate??, posted by ColoradoSnowflake on January 24, 2010, at 22:27:13
> Hi Everybody:
>
> I'm down to 30mg/day Parnate (plus 150mg Provigil and 5mg Nortriptyline). Side effects all lessening.
>
> I'd like to try DLPA but remember seeing something about phenylalynine (sp?) being a no-no with Parnate? I'm not planning on coming totally off Parnate if I can help it.
>
> Do any of you guys know??
>
> Thanks,
>See if you can stay at 30 mg as that is the minimum therapuetic dose. There was a post about some doc using tyrosine with parnate for sleepiness. DLPA is a precursor to tyrosine. So there is conflcting info on that. Some docs let their patients cautiously use stims with parnate. If you decide to experiement start low. It comes in 500 mg pills but maybe try 50 mg first. See what you can find in the archives before you start. I believe one babbler may have used that combo. Hope you are feeling better.
Posted by bleauberry on January 25, 2010, at 17:17:10
In reply to Is DLPA OK with Parnate??, posted by ColoradoSnowflake on January 24, 2010, at 22:27:13
Well, you might be in somewhat uncharted waters with this one.
I'm thinking potential for overstimulation and/or blood pressure spike would be the main things to look out for. On one hand, the D part of DLPA could be good in slowing down the breakdown of natural opioid endorphins...sort of like a mild MAOI of endorphins. The rest of it is going to the adrenaline circuits.
I would think dipping your toes in the water cautiously with very low doses wouldn't be a bad idea. I'm thinking 25mg to 50mg per day for a few days. Take it between meals for best absorption. If you want to buffer it for more safety, take it with food.
Decades ago two clinical studies used DLPA to treat major depression and the success rates were very high...the doses were only in the neighborhood of 150mg per day, far lower than the 500mg doses sold. Time to response was about 30 days. I imagine response could be quicker with higher doses, but then, that might not actually be a longterm adaptive response, but rather a short-term stimulation that would build tolerance.
I don't know why they make such large doses.
Potential is there, but respect the risks. Keep the doses very low for a week or two until you know what it is doing. That's what I would do anyway.
Posted by ColoradoSnowflake on January 25, 2010, at 17:50:21
In reply to Re: Is DLPA OK with Parnate??, posted by bulldog2 on January 25, 2010, at 9:09:20
Thanks, guys!
That totally helps me! I'll do just as suggested.
It would be nice if DLPA could supplant the Provigil!
xxooxx
Posted by floatingbridge on January 26, 2010, at 0:01:13
In reply to Thanks Bulldog and Bleau!, posted by ColoradoSnowflake on January 25, 2010, at 17:50:21
Gayle, why dpla?
densely yours,
fb
> Thanks, guys!
>
> That totally helps me! I'll do just as suggested.
>
> It would be nice if DLPA could supplant the Provigil!
>
> xxooxx
>
>
Posted by bulldog2 on January 26, 2010, at 9:06:50
In reply to Re: Thanks Bulldog and Bleau! » ColoradoSnowflake, posted by floatingbridge on January 26, 2010, at 0:01:13
> Gayle, why dpla?
>
> densely yours,
>
> fb
>
>
> > Thanks, guys!
> >
> > That totally helps me! I'll do just as suggested.
> >
> > It would be nice if DLPA could supplant the Provigil!
> >
> > xxooxx
> >
> >
>
>for some extra ne, da and pea
Posted by floatingbridge on January 26, 2010, at 10:26:07
In reply to Re: Thanks Bulldog and Bleau!, posted by bulldog2 on January 26, 2010, at 9:06:50
> > Gayle, why dpla?
> >
> > densely yours,
> >
> >fb
>
> for some extra ne, da and peaOh, I'll look up pea. Thanks.
Posted by bulldog2 on January 26, 2010, at 10:39:05
In reply to Re: Thanks Bulldog and Bleau!, posted by floatingbridge on January 26, 2010, at 10:26:07
> > > Gayle, why dpla?
> > >
> > > densely yours,
> > >
> > >fb
> >
> > for some extra ne, da and pea
>
> Oh, I'll look up pea. Thanks.
>
>
http://neuro.psychiatryonline.org/cgi/content/abstract/8/2/168
Posted by floatingbridge on January 26, 2010, at 10:57:06
In reply to Re: Thanks Bulldog and Bleau!, posted by bulldog2 on January 26, 2010, at 10:39:05
Thanks. So maybe I could add it before any trial begins and see--not contra-indicated for any of my meds, and might increase efficacy of dex (reducing dosage), and o.k. to use if I go to emsam.
Good luck Gayle!
Bulldog, do you use it?
the suddenly enlightened,
fb
Posted by bulldog2 on January 26, 2010, at 11:23:27
In reply to Re: Thanks Bulldog and Bleau! » bulldog2, posted by floatingbridge on January 26, 2010, at 10:57:06
> Thanks. So maybe I could add it before any trial begins and see--not contra-indicated for any of my meds, and might increase efficacy of dex (reducing dosage), and o.k. to use if I go to emsam.
>
> Good luck Gayle!
>
> Bulldog, do you use it?
>
> the suddenly enlightened,
>
> fbI have used it with selegiline tabs (5-10 mg) and gotten fast results.
Posted by inanimate peanut on January 26, 2010, at 17:46:33
In reply to Re: Thanks Bulldog and Bleau!, posted by bulldog2 on January 26, 2010, at 11:23:27
Would you prefer use of DLPA over just tyrosine alone?
Posted by bleauberry on January 26, 2010, at 17:55:16
In reply to Thanks Bulldog and Bleau!, posted by ColoradoSnowflake on January 25, 2010, at 17:50:21
Please just be very careful trying this! By itself I would have no concerns. With Parnate, that is a whole different scenario. Uncharted waters. Starting dose equals 25mg. It will be very important to feel what is going on before increasing doses.
Provigil is unique and nothing can do what it does. For better or worse. DLPA could be tremendously better, or it could be a disaster. That's why I think it is wise to step into it very gently until you have a better sense of what's happening.
> Thanks, guys!
>
> That totally helps me! I'll do just as suggested.
>
> It would be nice if DLPA could supplant the Provigil!
>
> xxooxx
>
>
Posted by bulldog2 on January 27, 2010, at 16:01:22
In reply to Re: Thanks Bulldog and Bleau! » ColoradoSnowflake, posted by bleauberry on January 26, 2010, at 17:55:16
> Please just be very careful trying this! By itself I would have no concerns. With Parnate, that is a whole different scenario. Uncharted waters. Starting dose equals 25mg. It will be very important to feel what is going on before increasing doses.
>
> Provigil is unique and nothing can do what it does. For better or worse. DLPA could be tremendously better, or it could be a disaster. That's why I think it is wise to step into it very gently until you have a better sense of what's happening.
>
> > Thanks, guys!
> >
> > That totally helps me! I'll do just as suggested.
> >
> > It would be nice if DLPA could supplant the Provigil!
> >
> > xxooxx
> >
> >
>
>
No one really seems to know how provigil works. There are theories it blocks gaba and ups dopamine. I once took a whooing dose of 400 mg provigil and it felt like amphtemine.DLPA supplies extra material to make more pea and tyrosine to make more dopamine and norepinephrine. I wouldn't use both together with parnate.
Posted by ColoradoSnowflake on January 28, 2010, at 10:42:26
In reply to Re: Thanks Bulldog and Bleau!, posted by bulldog2 on January 27, 2010, at 16:01:22
Thanks to all of you for the good information!
I'm waiting for the DLPA to come in the mail....think I'll just put it on the shelf for another day!
The thing that had interested me the most about it was reading that it took away the pain from RA and cleared brain fog.
Even down to 30mg Parnate I am struggling with the RA.
A friend of mine gave me a little jar of "medicinal marijuana cream" to try. I rubbed it into my hands and wrists before I went to bed last night..... I went to sleep so fast I have no idea if it worked or not. At $25 for a very small jar I'm not impressed.....made my hands smell funny, too.
Posted by floatingbridge on January 28, 2010, at 11:01:44
In reply to Re: Thanks Bulldog and Bleau!, posted by ColoradoSnowflake on January 28, 2010, at 10:42:26
Gayle,
A number of people have reported relief w/ marijuana tincture. A few drops, and an hour or so. For deep muscular (and joint?) pain. I haven't tried it
Don't know why I didn't think of that before--and your state is med marijuana friendly!I've been reading that decreasing parnate creates the symptoms bothering you in non-RA sufferers as well. Coming and going; sorry your withdrawal is so rough.
hugs,
fb
Posted by Phillipa on January 28, 2010, at 20:29:13
In reply to Re: Thanks Bulldog and Bleau! » ColoradoSnowflake, posted by floatingbridge on January 28, 2010, at 11:01:44
Fb I sure didn't know that???? But then it's used for pain I think in Canada. Love Phillipa
Posted by floatingbridge on January 28, 2010, at 21:48:23
In reply to Re: Thanks Bulldog and Bleau! » floatingbridge, posted by Phillipa on January 28, 2010, at 20:29:13
> Fb I sure didn't know that???? But then it's used for pain I think in Canada. Love Phillipa
Hi Phillipa, yeah, I forgot I knew. :-)
Apparently from those who know, the tincture is effective in ways that eating or smoking are not.hugs!
fb
This is the end of the thread.
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