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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Laney on January 10, 2010, at 13:36:33
Just exploring my options and want to know about the differences in this class of drugs. Don't like to be sedated or sleepy at all.
Thanks! Laney
Posted by mtdewcmu on January 10, 2010, at 19:23:11
In reply to Least sedating TCA, posted by Laney on January 10, 2010, at 13:36:33
> Just exploring my options and want to know about the differences in this class of drugs. Don't like to be sedated or sleepy at all.
>
> Thanks! LaneyProbably desipramine, based on its relative lack of unwanted effects. Although there may be others that are so stimulating that the stimulation overcomes the sedation.
Posted by softheprairie on January 13, 2010, at 5:15:30
In reply to Least sedating TCA, posted by Laney on January 10, 2010, at 13:36:33
Yeah, I was going to suggest desipramine also.
It's significantly lower incidences of sedation or weight gain were much of the cause of me asking to try it, and it has been a winner for me!
I do have cardiac side effects, though. EKG showed just plain high heartrate (tachycardia), not abnormal rhythm other than fast, which is controlled with a beta blocker that has been added (nebivolol/Bystolic). My recent EKG was normal, I was told.I will say, I am still on it, but unfortunately, there was a new FDA warning that came out about it Dec. 2, 2009 (not bad that the warning was issued, but that it seems to be warranted/true). There is risk of sudden death on it, particularly if one has a family history of sudden death due to heart attack, which is exactly my case. In consultation with my pdoc, I tried to decrease my does of desipramine, from 300 mg/day. I went to 250, on my way to try 200, but I never got to the 200. My mood was worse at the 250. I gave it 13 days, and then didn't want to keep the worse mood, and went back to the 300. Maybe you can do well with it at a lower dose, which is safer.
This is the end of the thread.
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