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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by inanimate peanut on January 6, 2010, at 20:58:34
How many of you are or have been on Wellbutrin and Parnate? I tried and failed to get the article that I have the cite for about using the 2 together.
Can anyone get ahold of Pierre J, Gitlin M: Bupropion-tranylcypromine combination for treatment-refractory depression (letter). Journal of Clinical Psychiatry 2000;61 (June):450451? I really, really need this article. I tried buying it from the website and the link they gave me was faulty (and now I can't get ahold of them to refund my $20)
Out of all of my options I would like to try this one next. Wellbutrin always worked really well for me and I'm hoping it's the one exception to the rule that whenever I stop something it never works for me again. If it works, then I'll have to worry about trying to get my doc to prescribe it or otherwise getting ahold of it.
Willey-- if you could find that other more in-depth article, I would be eternally grateful!!! I've looked and looked to no avail.
Posted by Phillipa on January 6, 2010, at 21:45:00
In reply to Wellbutrin and Parnate, posted by inanimate peanut on January 6, 2010, at 20:58:34
Peanut slow down???? Phillipa
Posted by SLS on January 7, 2010, at 5:47:16
In reply to Wellbutrin and Parnate, posted by inanimate peanut on January 6, 2010, at 20:58:34
I tried Parnate + Wellbutrin. I did not have any bad reactions.
- Scott
Posted by jedi on January 7, 2010, at 9:38:34
In reply to Re: Wellbutrin and Parnate, posted by SLS on January 7, 2010, at 5:47:16
> I tried Parnate + Wellbutrin. I did not have any bad reactions.
>
>
> - ScottHi Guys,
I have not used Wellbutrin with Parnate. I'm going to assume it would be very activating. I have used both meds separately. Though contraindicated I did use Wellbutrin with Nardil over an extended period. The Wellbutrin did seem to counteract some of the negative Nardil side effects. Might be just me but Wellbutrin tends to make me somewhat aggressive. Might watch out for that one.
Jedi
Posted by inanimate peanut on January 7, 2010, at 11:37:48
In reply to Re: Wellbutrin and Parnate » inanimate peanut, posted by Phillipa on January 6, 2010, at 21:45:00
I'm not starting this for a couple weeks until I see if the light therapy I'm doing works. I'm only trying things one thing at a time (with the exception of the NAC which I'm going ahead and taking). I'm doing it safely. I knew other people on the site had done it, so I was just curious how many and how much they took. I will take my blood pressure throughout the day for the first days and then morning and night. There are academic journal articles saying it's ok to do. Yes, I rushed into the high doses of Parnate. Yes, that was a mistake. But, I know what I'm doing with this and you don't need to worry. I invite anyone who has specific concerns to express them.
Posted by willey on January 7, 2010, at 14:06:41
In reply to Wellbutrin and Parnate, posted by inanimate peanut on January 6, 2010, at 20:58:34
Like scott ive used parnate in combo with wellbutrin,and i dident not like it.I cant think at the moment what i remeber people sayin worked in combo,but i believe this is your article,its from the babble archive,save it and use it with the info now to more easly find it on the net.
I could be wrong but appearently to me seemed to have disappeared.Please be sensable about your choice,and make sure you have sufficient back up to ensure it has some safety,merry late xmas for you,and thanks to the orignal posters of this info.
Posted by inanimate peanut on January 7, 2010, at 22:14:08
In reply to Re: Wellbutrin and Parnate, posted by willey on January 7, 2010, at 14:06:41
I don't see anything about Wellbutrin and Bupropion in this article, but it is good for TCA and stimulant articles. I'll just keep looking for more on Wellbutrin and Parnate/
Posted by willey on January 8, 2010, at 1:19:56
In reply to Re: Wellbutrin and Parnate » willey, posted by inanimate peanut on January 7, 2010, at 22:14:08
Sworn i gave this to you already.
For links and actual data,id go to pub med. with info from the bottom
BupropionTranylcypromine for Refractory DepressionThe combination of bupropion and tranylcypromine was used safely and successfully in a patient with chronic, treatment-resistant depression.1
A 27-year-old woman had a history of chronic major depression that had been refractory to trials of an SSRI and various TCAs, plus adjunctive methylphenidate. She had been started on 150 mg/day bupropion, and 2 months later, tranylcypromine was added and titrated to 50 mg/day. Her depressive symptoms slowly resolved.
Five months later, bupropion was tapered and stopped. Within 2 weeks her depressive symptoms recurred, but resolved after bupropion was restarted. A subsequent attempt to withdraw tranylcypromine was associated with a recurrence of mood symptoms.
For the last 2 years, she has remained on a regimen of 150 mg bupropion SR b.i.d. and 60 mg/day tranylcypromine, with no recurrence of depression. During that time she had 1 episode of symptomatic hypertension after eating cheese, which was managed at home with nifedipine. She has nifedipine available for a hypertensive crisis, and uses low-dose lorazepam as needed for mild transient episodes of stress-related dysphoria or insomnia.
According to the criteria of Thase and Rush, this patients poor response to multiple antidepressant trials classifies her depression at Stage IV resistance, making her a candidate for ECT.2 However, she preferred to stay employed and to receive outpatient treatment.
Discussion: The combination of bupropion and an MAOI is not generally recommended, because it can increase the risk for hypertensive crisis or may risk bupropion toxicity.3,4 However, cautious coadministration of bupropion and tranylcypromine may be a viable therapeutic option in patients who are unresponsive to trials of antidepressants.
1. Pierre J, Gitlin M: Bupropion-tranylcypromine combination for treatment-refractory depression (letter). Journal of Clinical Psychiatry 2000;61 (June):450451. From UCLA Neuropsychiatric Institute, Los Angeles, Calif.
2. Thase M, Rush A: When at first you dont succeed: sequential strategies for antidepressant nonresponders. Journal of Clinical Psychiatry 1997;58 (suppl 13):2329.
3. Kaplan H, Sadock B, eds. Comprehensive Textbook of Psychiatry. 6th ed. Baltimore, Md: Lippincott, Williams & Wilkins; 1995.4. Product information. Bupropion (Wellbutrin). Glaxo Wellcome. May 1997.
Drug Trade Names: bupropionWellbutrin; lorazepamAtivan; methylphenidateRitalin;
nifedipineAdalat, Procardia; tranylcypromineParnate
Posted by willey on January 8, 2010, at 1:32:08
In reply to Re: Here ya go..., posted by willey on January 8, 2010, at 1:19:56
Ok im too tired now to see why no abstracts are available on this for a link,perhaps its charagble now.
I did however find another that was available thats a little better,
Enjoy!
Posted by inanimate peanut on January 8, 2010, at 22:20:26
In reply to Re: Here ya go..., posted by willey on January 8, 2010, at 1:19:56
Thanks! You did already give this one to me. I'm trying to get ahold of the full article cited in reference number 1. I would like to know dosages, more details. etc. I tried to buy the article online and just got an error link (and now they won't call me back and just kept my $20). I'm just trying to find the full text of the article just in case anyone happened to have access rights that I don't have or if anyone knew of any other Wellbutrin-parnate articles. Sorry, I didn't mean to make you have to post that again. I appreciate all your help!
Posted by willey on January 8, 2010, at 23:05:16
In reply to Re: Here ya go..., posted by inanimate peanut on January 8, 2010, at 22:20:26
Yeah ill tell u how to get it,go to ur libary,tell them what ur trying to do,and a secret is all those abstracts that charge,i could be wrong BUT my understanding is they are free at the libary on their pc`s
This is the end of the thread.
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