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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by julie1977 on January 5, 2010, at 10:41:42
I'm thinking of upping my dose from 75mg to 90mg, the tablets are 15mg otherwise I would've only upped to 85mg. I weigh 67kg aka ten and a half stone. Has anyone else here taken a high dose of Nardil and was it beneficial? Thanks. Julie
Posted by willey on January 5, 2010, at 12:58:06
In reply to Highest dose of Nardil users have taken?, posted by julie1977 on January 5, 2010, at 10:41:42
This is in no way,no how,me advocating any dose average of this drug.In fact having never been on it but for a week i dont even know what is standered dose,however this article sounded like it might come of some use,
http://archpsyc.ama-assn.org/cgi/content/abstract/35/5/629
*******Our data show that a safe, effective phenelzine dose is 1 mg/kg body weight per day.*****
"AbstractThere is renewed interest in the clinical pharmacology of phenelzine sulfate and other monoamine oxidase (MAO) inhibitors. Newer clinical and analytic techniques recently have been applied to investigations of this class of drugs in man. The results show that drugs such as phenelzine are effective in nonendogenous depression and phobic disorders. Clinical response to phenelzine is related to platelet MAO inhibition and dosage per unit body weight. High percent MAO inhibition in platelets at two weeks is associated with greater improvement after a six-week course of treatment. Our data show that a safe, effective phenelzine dose is 1 mg/kg body weight per day. These results have delineated the pharmacologic and therapeutic effects of phenelzine and support a continuing role for MAO inhibitors in psychopharmacology."
Posted by Phillipa on January 5, 2010, at 13:03:27
In reply to Re: Hope this helps, posted by willey on January 5, 2010, at 12:58:06
Wonder if Ace will see this thread? Phillipa
Posted by willey on January 5, 2010, at 13:27:18
In reply to Re: Hope this helps » willey, posted by Phillipa on January 5, 2010, at 13:03:27
Im thinking ace has learned a lot being on nardil as long as he has,its evident in his posts,and like many maoi long term users probuably know more then the average p-doc.
As for providing better info,i think we need to watch how we report things,in effort to harmlessly pass info,we can unconcously seem to be advovating the info we post,perfect example posting doucments out there on high dose maoi use.
Doesent mean we dont mean well,doesent mean the reader did wrong,its just one of those things.
I stick to the simple term of "maois in high dose treatment" and try to seek any published reliable data,and with my opinion im saying for the first time now,stop telling people to do or that without your doc,i believe we are adults,and if we choose to use the abundance of info out,info thats credable,then how we view a docs invovlment is a personal prefence.
We all share the same goal,which is is simple,inform further then what we get,get well,and stay safe,and everyone has their own way to which they utlize their treatment,if anyone thinks a doc cant be as dangeours as self involment NOT SELF MEDICATING then they had a good doc,i can testify that there are docs who can be just as dangerous,i almost killed myself at 19 due to the lack of information from my doc,had i been told to expect effexor with drawal,what to expect,provided something to aid,i would not have been totaly in the dark and think i was loosing mymind forever,i would have found safty in knowing it would pass,and would have valued any additonal medical help which i soo neded.
Instead i got not a thing from my doc,and with no info or boards at the time still consider myself lucky to have made it through,so imagine why i might not consider a docs invovlement so critical,and again it doesent make the case for everyone,but it also doesent make me irrepsonable to choose to treat myself the way i do today,which is by a 360 method of various borads,u guys my fav!.....published and reliable documents,actual pharmocology and so on,things my doc would never utilize anyway.
Posted by julie1977 on January 5, 2010, at 15:43:11
In reply to Re: Hope this helps, posted by willey on January 5, 2010, at 13:27:18
thanks for the replies. I'm already taking more than my weight's worth, ie. 75mg and I weigh 67kg, or maybe 68kg after xmas ;-).
I wonder if anyone has ever stayed permanently well on a med on this board.
After my 'success' story i've been feeling depressed in the evenings, like now, 21:42 here in the UK.
Posted by pedr on January 6, 2010, at 15:53:58
In reply to Re: Hope this helps, posted by julie1977 on January 5, 2010, at 15:43:11
> thanks for the replies. I'm already taking more than my weight's worth, ie. 75mg and I weigh 67kg, or maybe 68kg after xmas ;-).
> I wonder if anyone has ever stayed permanently well on a med on this board.
> After my 'success' story i've been feeling depressed in the evenings, like now, 21:42 here in the UK.
>
>> thanks for the replies. I'm already taking more than my weight's worth, ie. 75mg and I weigh 67kg, or maybe 68kg after xmas ;-).
> I wonder if anyone has ever stayed permanently well on a med on this board.
> After my 'success' story i've been feeling depressed in the evenings, like now, 21:42 here in the UK.
>I asked my PDoc (who is awful, unfortunately) and he'd never heard of the weight - mg ratio. Some PDocs use it, some don't from what I can gather. Since different people will absorb and metabolize at different rates, according to all sorts of factors, the only way to tell what level of the drug (or its metabolites or whatnot) you have in your bloodstream is a blood serum test I believe.
That said, I don't know what the "best" or "correct" level is. "Until you feel better" is probably widely used!
I'm currently on 75mg Nardil + 100mg Lamictal with the goal of moving to 90mg Nardil alone. Nardil is and (I'm desperately, desperately hoping) will remain my wonder drug. That said, I'm still way off being "well". Hence my goal of 90mg. I figured that 75mg might be giving me partial remission. I've also put on 30lb in weight since going on it, which means 90mg will be spot-on for my weight according to the weight-mg theory.
Pete
Posted by willey on January 6, 2010, at 17:54:50
In reply to Re: Hope this helps » julie1977, posted by pedr on January 6, 2010, at 15:53:58
Who really gave me in depth info on that aspect was a old poster ChairMan Maoi,he through emails would tell me facts that i never knew on maois.
Very technical ones.He even bought his maois in the chemical form and encapsulated them to have less single pills to take.
This i found strange,until one day he forgot to take his signature off a email,and his info included he was part of some colleges chem team which would allow you to easly purchase chemicals but also made sense of how he knew so much info that was not available online.
They actualy can test maoi levels,but of course unless its in a study its not part of routine therapy.
Posted by jedi on January 7, 2010, at 10:21:06
In reply to Highest dose of Nardil users have taken?, posted by julie1977 on January 5, 2010, at 10:41:42
> I'm thinking of upping my dose from 75mg to 90mg, the tablets are 15mg otherwise I would've only upped to 85mg. I weigh 67kg aka ten and a half stone. Has anyone else here taken a high dose of Nardil and was it beneficial? Thanks. Julie
Hi Julie,
I have taken phenelzine up to 120mg for a short time. The usual max dosage is 90mg even though it is quoted that the effective dose is 1mg per kg or body weight. Everybody is different and I don't really think you can go with this formula. I currently have been able to lower my dosage to 60mg after many years at 90mg. The side effects of the medication are so much less for me at this lower dosage. I am a large man and at the time I was using 120mg I was about 130kg body weight.Sometimes it takes the higher dosages to work. I also augment with 2mg daily of clonazepam for my social anxiety. Since both medications affect GABA, they seem to work synergistically for this affliction. The trouble with long term benzo usage is the affect on memory. CRS, if you know what I mean.
Good Luck,
Jedi
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