Psycho-Babble Medication Thread 919132

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How does Abilify augment antidepressants?

Posted by number42 on September 30, 2009, at 12:00:32

I recently added Abilify 20 mgs. to 80 mgs. of Prozac and i am doing so much better. Anyone familiar with how an anti-psychotic enhances an AD?

#42

P.S. My diagnosis is bipolar 2, i also take 200 mgs. of Lamictal daily.

Re: How does Abilify augment antidepressants? » number42

Posted by Phillipa on September 30, 2009, at 13:10:25

In reply to How does Abilify augment antidepressants?, posted by number42 on September 30, 2009, at 12:00:32

Hi I did a search and couldn't find mechanism of action. Sorry about that. Phillipa

Re: How does Abilify augment antidepressants?

Posted by SLS on September 30, 2009, at 14:50:58

In reply to How does Abilify augment antidepressants?, posted by number42 on September 30, 2009, at 12:00:32

> I recently added Abilify 20 mgs. to 80 mgs. of Prozac and i am doing so much better. Anyone familiar with how an anti-psychotic enhances an AD?

With Abilify, there are probably at least three mechanisms involved:

1. Dopamine D2 and D3 receptor partial agonism.

2. Serotonin 5-HT2a receptor antagonism.

3. Serotonin 5-HT1a receptor partial agonism.

The net effect here is to increase dopamine and serotonin activity.

Linkadge could probably add some insight into what are the downstream effects of these events.

- Scott

Re: How does Abilify augment antidepressants? » SLS

Posted by number42 on October 1, 2009, at 11:09:57

In reply to Re: How does Abilify augment antidepressants?, posted by SLS on September 30, 2009, at 14:50:58

> > I recently added Abilify 20 mgs. to 80 mgs. of Prozac and i am doing so much better. Anyone familiar with how an anti-psychotic enhances an AD?
>
> With Abilify, there are probably at least three mechanisms involved:
>
> 1. Dopamine D2 and D3 receptor partial agonism.
>
> 2. Serotonin 5-HT2a receptor antagonism.
>
> 3. Serotonin 5-HT1a receptor partial agonism.
>
> The net effect here is to increase dopamine and serotonin activity.
>
> Linkadge could probably add some insight into what are the downstream effects of these events.
>
>
> - Scott

Thanks Scott.

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