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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by Dinah on September 27, 2009, at 4:30:01
http://dermatology.jwatch.org/cgi/content/citation/2002/611/8
I did not know this. But it appears to be true, for me at least.
Not the worst thing in the world. I got some caulking and paint prep done today.
I'll call my pdoc tomorrow to see if I should do anything. Aside from stopping the prednisone. I'd rather be hypomanic than hivey.
Posted by SLS on September 27, 2009, at 7:01:20
In reply to Prednisone and hypomania, posted by Dinah on September 27, 2009, at 4:30:01
> http://dermatology.jwatch.org/cgi/content/citation/2002/611/8
>
> I did not know this. But it appears to be true, for me at least.
>
> Not the worst thing in the world. I got some caulking and paint prep done today.
>
> I'll call my pdoc tomorrow to see if I should do anything. Aside from stopping the prednisone. I'd rather be hypomanic than hivey.Prednisone can also produce psychosis with hallucinations. My guess is that you are not apt to react this way, or I think you would have by now.
- Scott
Posted by Alexanderfromdenmark on September 27, 2009, at 7:49:08
In reply to Prednisone and hypomania, posted by Dinah on September 27, 2009, at 4:30:01
Then you must be using a very high dosage.
What are you taking it for?
Posted by seldomseen on September 27, 2009, at 8:02:11
In reply to Prednisone and hypomania, posted by Dinah on September 27, 2009, at 4:30:01
This reaction is quite normal on prednisone. Were you prescribed the Medrol Pak? If so, with the declining dose, you should notice a resolution of this symptom.
Seldom
Posted by Phillipa on September 27, 2009, at 11:03:10
In reply to Re: Prednisone and hypomania, posted by seldomseen on September 27, 2009, at 8:02:11
Didn't happen to me the one time I took the medrol for loss of taste and smell but my sister gets psychiatric symptoms when takes for poison ivy. Phillipa
Posted by Dinah on September 27, 2009, at 12:53:20
In reply to Re: Prednisone and hypomania, posted by Phillipa on September 27, 2009, at 11:03:10
It sounds like the Medrol pack. She didn't give me a name. Just handed me three paper envelopes with instructions on each.
It was being given for a miliaria, so this should be short term. If I'm remembering the packets right, another week.
I'll call my pdoc if it causes me problems. But I'm sort of hoping it lasts a bit longer. I'm getting a lot done. As long as it doesn't get worse than it is now, I think I'll enjoy it.
I do have to be careful about doing too much physical activity and sweating more though. And I'm driving my husband batty by being speeded up enough that not only do I annoy him, but he is seeming to me to be soooooo slooowwwww.
Thanks. I never realized there was a connection before now. This explains the reaction a dog of mine had. He had pancreatic cancer, and just before he died, the doctor prescribed prednisone. He had the best weekend he'd had in months. Rolled on the grass like a puppy. Then died of a heart attack on Tuesday. But I've had a couple of others on it long term who had no brain reaction at all that I could see.
Posted by Alexanderfromdenmark on September 27, 2009, at 13:40:37
In reply to Re: Prednisone and hypomania, posted by Dinah on September 27, 2009, at 12:53:20
I'm taking 30 mg hydrocortisone a day. I don't know why doctors are so paranoid about presribing cortisol and then go on to presribe them in such high dosages as with you.
I seeing all benefits from mine and know mania or side effects.
Posted by Jimmyboy on September 27, 2009, at 22:10:35
In reply to Re: Prednisone and hypomania, posted by Alexanderfromdenmark on September 27, 2009, at 13:40:37
They are not worried about prescribing high doses b/c she is not going to be on prednisone long enough for it to shut down her HPA axis.
Where as it sounded like you are taking HC regularly so you need to have a low enough dose that your body doesn;t stop making endogenous cortisol is my guess.
Posted by Dinah on September 27, 2009, at 22:41:09
In reply to Re: Prednisone and hypomania, posted by Jimmyboy on September 27, 2009, at 22:10:35
Yup.
My experience with my dogs on long term prednisone is that it not only causes bloating and excessive urination, but hair loss, thinned corneas, kidney (or liver maybe) problems and generally a greatly decreased lifespan.
As much as I'm enjoying the hypomania, I'm very glad I have never had reason to enjoy it before, and I'm glad I won't have reason to enjoy it long.
Posted by SLS on September 28, 2009, at 5:22:07
In reply to Re: Prednisone and hypomania, posted by Dinah on September 27, 2009, at 22:41:09
> As much as I'm enjoying the hypomania, I'm very glad I have never had reason to enjoy it before, and I'm glad I won't have reason to enjoy it long.
You are truly wise.
I hope you don't experience a rebound depression when it comes time for you to discontinue the prednisone. If you do become depressed, just know that it is a temporary reaction. I imagine that if you taper the right way, this will not become an issue.
- Scott
Posted by sam K on September 28, 2009, at 15:18:58
In reply to Re: Prednisone and hypomania » Dinah, posted by SLS on September 28, 2009, at 5:22:07
prednisone messed me up... I took it for a few days and got really manic, then I dropped it and yea, talk about rebound. But it ended up being okay.
Posted by desolationrower on September 30, 2009, at 0:34:21
In reply to Re: Prednisone and hypomania, posted by sam K on September 28, 2009, at 15:18:58
yeah cortisol makes you feel good. just don't go and get stressed and waste it, because then it won't work when you need it
Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression.
Pace TW, Hu F, Miller AH.
Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute, Emory University School of Medicine, 101 Woodruff Cricle, Suite 4000, Atlanta, GA 30322, USA.
Glucocorticoids play an essential role in the response to environmental stressors, serving initially to mobilize bodily responses to challenge and ultimately serving to restrain neuroendocrine and immune reactions. A number of diseases including autoimmune, infectious and inflammatory disorders as well as certain neuropsychiatric disorders such as major depression have been associated with decreased responsiveness to glucocorticoids (glucocorticoid resistance), which is believed to be related in part to impaired functioning of the glucocorticoid receptor (GR). Glucocorticoid resistance, in turn, may contribute to excessive inflammation as well as hyperactivity of corticotropin releasing hormone and sympathetic nervous system pathways, which are known to contribute to a variety of diseases as well as behavioral alterations. Recent data indicate that glucocorticoid resistance may be a result of impaired GR function secondary to chronic exposure to inflammatory cytokines as may occur during chronic medical illness or chronic stress. Indeed, inflammatory cytokines and their signaling pathways including mitogen-activated protein kinases, nuclear factor-kappaB, signal transducers and activators of transcription, and cyclooxygenase have been found to inhibit GR function. Mechanisms include disruption of GR translocation and/or GR-DNA binding through protein-protein interactions of inflammatory mediators with the GR itself or relevant steroid receptor cofactors as well as alterations in GR phosphorylation status. Interestingly, cAMP signal transduction pathways can enhance GR function and inhibit cytokine signaling. Certain antidepressants have similar effects. Thus, further understanding the effects of cytokines on GR signaling and the mechanisms involved may reveal novel therapeutic targets for reversal of glucocorticoid resistance and restoration of glucocorticoid-mediated inhibition of relevant bodily/immune responses during stress and immune challenge.
depression: using your energy to worry instead of to conquer-d/r
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