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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by rjlockhart04-08 on September 24, 2009, at 22:07:04
I just wanted to post on this. I took Seroquel for a while, 100mg. It for reason caused the mindstate to change. Yes, i know it causes sleepliness, but there was something about it. Dopamine and histimane blockage caused, a "drowy, delirium" like state. Didnt do well, yet it's in the class of antipsychotic's
Anyone else?
Posted by Phillipa on September 24, 2009, at 23:58:38
In reply to Seroquel, posted by rjlockhart04-08 on September 24, 2009, at 22:07:04
50mg and I could think but not speak and almost fainted had to be put to bed. Love Phillipa
Posted by yxibow on September 25, 2009, at 1:29:40
In reply to Seroquel, posted by rjlockhart04-08 on September 24, 2009, at 22:07:04
> I just wanted to post on this. I took Seroquel for a while, 100mg. It for reason caused the mindstate to change. Yes, i know it causes sleepliness, but there was something about it. Dopamine and histimane blockage caused, a "drowy, delirium" like state. Didnt do well, yet it's in the class of antipsychotic's
>
> Anyone else?I think what you're experiencing... I don't know about the delirium part, that sounds a bit concerning.... but most antipsychotics have a potential side effect called "blunting", which is actually part of their point, they are supposed to slow down certain Dx activity, but there can be a dazed feeling of being a bit out of the moment.
Its an unfortunate part of them but combined with other medications for example like Wellbutrin (not everyone can do this), one may be able to attain some uplifting feelings.
The actual loss of pleasure by loss of dopamine is usually strongest with the older typical antipsychotics from what I've heard.
-- tidings
Posted by Jeroen on September 25, 2009, at 8:11:35
In reply to Re: Seroquel » rjlockhart04-08, posted by yxibow on September 25, 2009, at 1:29:40
what about my experience in 2004 in the summer
you people tell about loss of happyness, i felt very happy for 2 months on seroquel 100 mg
i have yet to found out why it caused that in me.. and why the tolerance kicked in after 2 months and it never returned to me.... it's almost like spiritual relief moment.
Posted by sowhysosad on September 25, 2009, at 9:39:19
In reply to Seroquel, posted by rjlockhart04-08 on September 24, 2009, at 22:07:04
> I just wanted to post on this. I took Seroquel for a while, 100mg. It for reason caused the mindstate to change. Yes, i know it causes sleepliness, but there was something about it. Dopamine and histimane blockage caused, a "drowy, delirium" like state. Didnt do well, yet it's in the class of antipsychotic's
>
> Anyone else?I've been on a super-low dose of Seroquel - only 25mg at night.
However, even that's enough to make me feel drowsy, amotivational and antisocial the following day - the "blunting" effect Jay describes I think.
I was actually given it by a neuro to help with a movement disorder, not by a pdoc. Initially it was terrific for sleep and helped a little with fluoxetine-induced anxiety.
However, it didn't help one iota with the movement disorder and I really hate the doziness and "meh" feeling the following day.
Posted by moonshadow on September 25, 2009, at 17:14:16
In reply to Re: Seroquel » rjlockhart04-08, posted by sowhysosad on September 25, 2009, at 9:39:19
I take 1/2 of a 25 mg pill every night for sleep. It's enough to help me sleep well, but I don't have any odd effects the next day. I've been on this dose for about 2 months. A higher dose (25 mg), made me very drowsy the next day.
Posted by rjlockhart04-08 on September 25, 2009, at 21:47:19
In reply to Re: Seroquel » rjlockhart04-08, posted by Phillipa on September 24, 2009, at 23:58:38
Yea, 100mg, man i couldnt speak either. It just "zones" you.
Posted by rjlockhart04-08 on September 25, 2009, at 21:52:16
In reply to Re: Seroquel » rjlockhart04-08, posted by yxibow on September 25, 2009, at 1:29:40
I don't know, yes I do believe newer generation AP's are ment for better dopamine function.
What did you mean when you said Wellbutrin "uplifting" feelings? with Seroquel?
I start Wellbutrin tommorow. 150, then 300mg. Dextroamphetamine has always had uplifting "mood" effect, not euphoria (that would be at higher doses, that's why it's known for abuse) usally the best dose is 15mg, or 2 spansules twice daily. That's what I was on.
Thnks
Posted by rjlockhart04-08 on September 25, 2009, at 21:55:18
In reply to but what about my experience, posted by Jeroen on September 25, 2009, at 8:11:35
Maybe it's good for you. Alot of diffrent med's have diffrent patterns on people.
Glad it works for you. It's just when i would take 100mg at night, it would last till the next morning, say 9am, and i would take dex spansules, it blocked their dopamine effect until it totally wore off, which is about 12 hour's with good metabolism. Say take it at 10pm lasted till 10 the next morning.
Posted by rjlockhart04-08 on September 25, 2009, at 21:59:04
In reply to Re: Seroquel » rjlockhart04-08, posted by sowhysosad on September 25, 2009, at 9:39:19
I think I have something similar, yet i'm not diagnosing myself. The amotivational feeling you described, sometimes i feel it during the day and it's feeling like you "helpless" your stuck this way. That's why, dopamergic medicaitons are good, because they boost you out of that state, yet with some people it causes instablity. I take Zyprexa, it help's with social anxiety.
25mg i would take sometimes during the day for anxiety, but it didnt work directly on the "core" root. Benzodiapines have alway's helped because they work in a certain sector that calms anxiety.
Posted by rjlockhart04-08 on September 25, 2009, at 22:01:23
In reply to Re: Seroquel, posted by moonshadow on September 25, 2009, at 17:14:16
never take a antihistamine with seroquel, it increases it's effect. I think it target's histamine.
I rerember Seroquel just made me in a wierd mindstate.
Thnks
Posted by sowhysosad on September 26, 2009, at 10:32:07
In reply to Re: sowhysosad, posted by rjlockhart04-08 on September 25, 2009, at 21:59:04
> I think I have something similar, yet i'm not diagnosing myself. The amotivational feeling you described, sometimes i feel it during the day and it's feeling like you "helpless" your stuck this way.
Yeah, I just don't think D2 blockade agrees with me.
Yesterday I took the opposite approach and boosted dopamine. I took 1g of L-Tyrosine split into two doses, plus 5mg of NADH.
The net result was that I felt better yesterday evening than I have in months. Assuming that it was the dopamine that did it for me, it's no wonder Seroquel makes me worse.
Posted by yxibow on September 27, 2009, at 4:55:55
In reply to Re: yxibow, posted by rjlockhart04-08 on September 25, 2009, at 21:52:16
> I don't know, yes I do believe newer generation AP's are ment for better dopamine function.
>
> What did you mean when you said Wellbutrin "uplifting" feelings? with Seroquel?
>
> I start Wellbutrin tommorow. 150, then 300mg. Dextroamphetamine has always had uplifting "mood" effect, not euphoria (that would be at higher doses, that's why it's known for abuse) usally the best dose is 15mg, or 2 spansules twice daily. That's what I was on.I used to know someone who had psychotic depression who was on both Seroquel and Wellbutrin... its not that uncommon a combination.... but that's neither here nor there, we're not talking about that specific type of illness.
I didn't mean uplifting in the sense of mania or narcotic euphoric pleasure, I meant that it would be stimulating and possibly counter some of the blunting effects.
-- tidings
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