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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by ColoradoSnowflake on September 23, 2009, at 23:49:37
Hi Everybody:
I'm sorry I haven't been posting. I haven't been sure what to say about Parnate. I've been on a real roller coast ride, never knowing what twist or turn was coming next.
I have felt really good and terribly depressed, and at one point felt it had pooped out totally.
A big piece seems to be not only how much Parnate to take but WHEN to take it.
Pdoc upped me to 70mg/day, taken afternoon and evening. This seems to be much much better for me. I've been doing this for 4 or 5 days. Every night I'm afraid I'll have insomnia. That's been erratic, also.
This change to late afternoon and evening is making Parnate much more effective for me. Also raising it to 70mg is good.
So I'd say Parnate is working very well for me right now. I have to push myself to start projects more, but once I start I can see it through to the end. My feelings are much more at the surface and don't feel blunted like they were, (that's good and bad!). I have very little social anxiety or GAD either. I think having so little anxiety is what makes me kind of lazy, whereas it was fear/anxiety that kept me from initiating things before
Overall, it's very good. I just wish I had more motivation to START things. But I'm getting better. My mood is much better, brighter, confident with more humor too. People notice it in my voice.
I wish I had a source for Provigil. I'm taking adrafinil but it isn't nearly as strong, in my estimation, but better than nothing. Also, taking Parnate at night makes me not so tired during the day. That is getting much better.
Parnate is working far far better than anything else I've ever been on.
I hope it continues!
****Scott, and others who take Parnate, do you think I could take all 7 tablets at once at bedtime?? ****
Right now I'm taking 4 at about 6:30 and then 3 at 10 or 10:30 along with my Nortriptyline.Thanks,
Gayle
Posted by willyeee on September 24, 2009, at 0:16:31
In reply to Parnate Update, posted by ColoradoSnowflake on September 23, 2009, at 23:49:37
First let me say CONGRATS!Second you are at the point where most arrive finding its time to augment parnate,modfanil is not a bad choice.
3At bedtime,guy please dont youll never sleep
> Hi Everybody:
>
> I'm sorry I haven't been posting. I haven't been sure what to say about Parnate. I've been on a real roller coast ride, never knowing what twist or turn was coming next.
>
> I have felt really good and terribly depressed, and at one point felt it had pooped out totally.
>
> A big piece seems to be not only how much Parnate to take but WHEN to take it.
>
> Pdoc upped me to 70mg/day, taken afternoon and evening. This seems to be much much better for me. I've been doing this for 4 or 5 days. Every night I'm afraid I'll have insomnia. That's been erratic, also.
>
> This change to late afternoon and evening is making Parnate much more effective for me. Also raising it to 70mg is good.
>
> So I'd say Parnate is working very well for me right now. I have to push myself to start projects more, but once I start I can see it through to the end. My feelings are much more at the surface and don't feel blunted like they were, (that's good and bad!). I have very little social anxiety or GAD either. I think having so little anxiety is what makes me kind of lazy, whereas it was fear/anxiety that kept me from initiating things before
>
> Overall, it's very good. I just wish I had more motivation to START things. But I'm getting better. My mood is much better, brighter, confident with more humor too. People notice it in my voice.
>
> I wish I had a source for Provigil. I'm taking adrafinil but it isn't nearly as strong, in my estimation, but better than nothing. Also, taking Parnate at night makes me not so tired during the day. That is getting much better.
>
> Parnate is working far far better than anything else I've ever been on.
>
> I hope it continues!
>
> ****Scott, and others who take Parnate, do you think I could take all 7 tablets at once at bedtime?? ****
>
> Right now I'm taking 4 at about 6:30 and then 3 at 10 or 10:30 along with my Nortriptyline.
>
> Thanks,
>
> Gayle
>
>
Posted by g_g_g_unit on September 24, 2009, at 1:26:35
In reply to Parnate Update, posted by ColoradoSnowflake on September 23, 2009, at 23:49:37
hey that's great to hear. i hope things keep getting better for you. i called my doc and told him i'm having trouble sleeping, and asked if he didn't mind adding in a small TCA dose. he said he'd look at any information i have on the safety of the combination. how much nortrip do you take?
Posted by ColoradoSnowflake on September 24, 2009, at 3:42:15
In reply to Re: Parnate Update, posted by g_g_g_unit on September 24, 2009, at 1:26:35
I take only 25mg nortrip. I've tried more and it just doesn't work....too much.
But here I am, just woke up after zonking out watching the news, and it's 2:30 in the a.m.
I have to let my dog out , tidy up the kitchen and get ready for bed. I have to get up at 8a.m.
I'll let you know what happens. I wont let myself get up before that even if I'm awake. I will lie there in the dark or I'll take something, but I wont turn the light on after I've gotten into bed.
I hope I sleep now! We'll see!
Nighty, night!
Gayle
Posted by SLS on September 24, 2009, at 6:16:22
In reply to Parnate Update, posted by ColoradoSnowflake on September 23, 2009, at 23:49:37
You might be increasing the dosage of the wrong drug.
Nortriptyline.
- Scott
Posted by SLS on September 24, 2009, at 6:23:42
In reply to Re: Parnate Update, posted by ColoradoSnowflake on September 24, 2009, at 3:42:15
> I take only 25mg nortrip. I've tried more and it just doesn't work....too much.
I hadn't read this before submitting my post. Sorry.
There is a difference between concluding tha something doesn't work and deciding that the dosage is too much. What sorts of things did you experience that lead you to conclude that the higher dosage was too high?
Get a blood level.
Remember, the results of a dosage adjustment might take as long as 3 weeks to show benefit.
You are really close. Go with the increases in Parnate first, but don't forget about nortriptyline.
You probably have a lot of other things that you can try as adjuncts. Lamictal?
- Scott
Posted by james_ukglasgow on September 24, 2009, at 6:56:19
In reply to Re: Parnate Update » ColoradoSnowflake, posted by SLS on September 24, 2009, at 6:23:42
I was only on 30mg of Parnate and changing from taking it spread out across the day to a single dose caused a spontaneous hypertensive reaction, so I would advice caution on that one.
Posted by Phillipa on September 24, 2009, at 10:55:16
In reply to Re: Parnate Update, posted by james_ukglasgow on September 24, 2009, at 6:56:19
James are you okay now? Phillipa
Posted by james_ukglasgow on September 24, 2009, at 12:18:19
In reply to Re: Parnate Update » james_ukglasgow, posted by Phillipa on September 24, 2009, at 10:55:16
Hi Philipa
Thanks for asking.
I think I told you a while back I might have Addisons Disease, I beleive you said your Mother had it. It turned out I have complete pituitary failure so I am on oral hydrocortisone, thyroxine and testosterone injections. This has made a major difference as it must have been going on for years and was mistaken for mental illness and general laziness.
I still have a bit of depression, anxiety and insomina but I take fluoxetine, diazepam and nitrazepam and I am doing well on it. Thankfully I have not had any hypo/mania in a good year or two. I am hoping it wont come back now I am on hormone treatment.
Hope things are okay with you.
Take care
James
Posted by pedr on September 24, 2009, at 16:32:04
In reply to Parnate Update, posted by ColoradoSnowflake on September 23, 2009, at 23:49:37
>****Scott, and others who take Parnate, do you think I could take all 7 tablets at once at bedtime?? ****
>Right now I'm taking 4 at about 6:30 and then 3 at 10 or 10:30 along with my Nortriptyline.
This is pretty much what I was asking in my "Nardil dosage times irrelevant?" 09/19 post, which no-one has answered :(
My understanding (straight from Wikipedia) is that it shouldn't matter at all, since MAO takes 2 weeks to regenerate. The only difference you should experience would be in the side-effects experienced.
I am dying to know if this is right for 2 reasons:
1/ the last time I switched my dosage times, I had a terrifying crash back into deep depression. It could have been a complete co-incidence, but I'm not risking that again without more information.
2/ I want to change my dosage times because I keep on falling asleep (as in, actually asleep) at work and can barely concentrate I'm so somnolent.Info greatly appreciated,
Pete
Posted by Phillipa on September 24, 2009, at 20:13:23
In reply to Re: Parnate Update, posted by james_ukglasgow on September 24, 2009, at 12:18:19
James how wonderful to find a physical cause. Heathy healing to you. Love Phillipa
Posted by ace on September 24, 2009, at 22:43:32
In reply to Parnate Update, posted by ColoradoSnowflake on September 23, 2009, at 23:49:37
Posted by james_ukglasgow on September 25, 2009, at 3:12:17
In reply to Re: Parnate Update » james_ukglasgow, posted by Phillipa on September 24, 2009, at 20:13:23
Thanks, Philipa. I sent a reply to your babblemail.
Yep, it does feel strange to find that alot of what has gone on for years has turned out to have a physical cause. However, I am not completely out of the woods I wonder if years of SSRI's have changed how I feel and I have other things coming from childhood like OCD and social phobia symptoms that are not going away.
Cheers
James
Posted by Phillipa on September 25, 2009, at 21:33:28
In reply to Re: Parnate Update, posted by james_ukglasgow on September 25, 2009, at 3:12:17
James I feel the same as you in reguards to you. For years you look for a physical cause that in return causes anxiety as you know your own body and know when something is not right inside. I know I do. I think we should continue in private again. Love Phillipa
This is the end of the thread.
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