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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by philipmarlowe78 on September 23, 2009, at 14:42:04
Please, somebody, help me!
My medicines, Dexedrine and a benzodiazepine (Flunitrazepam/"Rohypnol") stopped working many years ago.
Even dramatic schemes, such not using them for two years, did not regenerate their effect in me when I started them again.
I used to get full effect from 20 mg. Dexedrine. Lately not even 100 mg. produces the desired effect, which is the original effect.
I hear talk about Ebixa (Memantine), which I am using with 2400 mg. Magnesium daily to stop that deadly calcium influx in its tracks.
I am also using "Lyrica" (Pregabalin) to further be coming down on that poisonous calcium influx in my NMDA-system or wherever it asserts its toxic effect on my cells.
What shall I do?
How can I, simply put, regenerate and rejuvenate the systems in my brain and body that causes me to respond correctly on therapeutic doses of pharmaceutical amphetamine, such as Dexedrine, and benzodiazepines, such as Rohypnol?
Yours sincerely,
philipmarlowe78
Posted by Phillipa on September 24, 2009, at 0:34:24
In reply to Dexedrine and Benzodiazepine Tolerance, posted by philipmarlowe78 on September 23, 2009, at 14:42:04
I don't know think a lot of others would also like to know. And welcome to babble. Phillipa
Posted by linkadge on September 24, 2009, at 19:58:13
In reply to Dexedrine and Benzodiazepine Tolerance, posted by philipmarlowe78 on September 23, 2009, at 14:42:04
To be honest, you are dealing with two classes with a high potential for tollerance and addiction. Unless you are a rockstar on the road - the upper/downer combination is kind of a bad path IMHO.
I don't know what to say, if 2 years off these medications did not reset tollerance I'm not sure what to say. I am just assuming you're not seeking a high. I am assuming you are seeking relief from ADHD and anxiety. In which case, a switch to a different class of meds may be warrented. A TCA like nortriptyline may help both.
With amphetamines the user almost never gets the same subjective high as they did the first time - even after (like you say) long period of abstainance. The brain can built up a memory for certain drugs. Addiction genes like delta-fos-b, which work to 'remember' drugs like this to prevent maladaptive responses to drugs.
Most of the NMDA antagonist reasearch is aimed at restoring the 'theraputic' effect of drugs like opiates and stimulants.
The first few times I took ritalin I got a buzz, but now I don't. It still works well for my attention though, so really I don't care about the buzz because to be honest it was a little distracting.
Linkadge
This is the end of the thread.
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