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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by jms600 on September 21, 2009, at 6:38:51
Has anyone had any success with treating panic disorder and GAD with Agomelatine?
Posted by Bob12 on September 21, 2009, at 10:10:43
In reply to Agomelatine/Valdoxan for anxiety??, posted by jms600 on September 21, 2009, at 6:38:51
> Has anyone had any success with treating panic disorder and GAD with Agomelatine?
I would like to know as well. I am hoping it will help treat anxiety and OCD.
Bob
Posted by Phillipa on September 21, 2009, at 10:45:19
In reply to Re: Agomelatine/Valdoxan for anxiety??, posted by Bob12 on September 21, 2009, at 10:10:43
Me also from what I've read some are helped some aren't. Phillipa
Posted by Helena24 on September 23, 2009, at 7:27:13
In reply to Agomelatine/Valdoxan for anxiety??, posted by jms600 on September 21, 2009, at 6:38:51
I take this drug for the last 10 days (together with high dose tianeptine).
I don't have many anxiety-issues or GAD but since i take agomelatine I feel agitated in a bad way.
I think I will quit the drug due to this discomfortable feeling.
Benzo's don't make it better.For me it is worthless for sleep.
It only made me tired the first 2-3 days and then nothing.
I took it at the morning then and the only effect I have from it is a *bad* agitation/not a good activation that I anticipated.I can hardly stand it and will quit.
Perhaps I will combine it with an SSRI in the future.
I've been also diagnosed with OCD but I think it's a wrong diagnosis.The doctors in my country "like" to make this diagnosis.
I have some OCD-like issues (to compensate ADD disfunctioning) and this issues didn't become worse or better by agomelatine.
I anticipated this drug for years and I'm dissapointed now,but perhaps it's to soon for valid conclusions.
Posted by Phillipa on September 23, 2009, at 20:44:23
In reply to Re: Agomelatine/Valdoxan for anxiety??, posted by Helena24 on September 23, 2009, at 7:27:13
Helena so sorry you feel so agitated and horrible. Phillipa
Posted by Helena24 on September 24, 2009, at 4:49:55
In reply to Agomelatine/Valdoxan for anxiety??, posted by jms600 on September 21, 2009, at 6:38:51
I did take the last pill of Valdoxan the day before yestarday and today I feel much better/less agitation and depression.
Another failed trial... :(
Posted by SLS on September 24, 2009, at 5:44:41
In reply to Re: Agomelatine/Valdoxan for anxiety??, posted by Helena24 on September 24, 2009, at 4:49:55
> Another failed trial... :(
Don't give up.
I had 27 years of failed trials before coming upon a treatment that seems to be working.
Disappointment, demoralization, helplessness, and hopelessness are perfectly human reactions to failed attempts to get well. I find that humor and spirituality help.
- Scott
Posted by Netch on September 24, 2009, at 9:51:31
In reply to Re: Agomelatine/Valdoxan for anxiety??, posted by Helena24 on September 24, 2009, at 4:49:55
> I did take the last pill of Valdoxan the day before yestarday and today I feel much better/less agitation and depression.
> Another failed trial... :(I second SLS. Dropping out after 10 days is too soon when it comes to agomelatine.
Posted by Helena24 on September 24, 2009, at 15:09:39
In reply to Re: Agomelatine/Valdoxan for anxiety?? » Helena24, posted by Netch on September 24, 2009, at 9:51:31
Thanks for the nice words.
Maybe it's to soon but it made me feel deeply unhappy.
I never experienced a drug to change it's way of action after the first week of treatment and I took dozents...The 4 week thing for example they tell about the ssri's never worked for me.
Every action was within the first week.I can't endure it at this point of my life.
Maybe I will try it again in the future.Other antidepressants that I didn't react well to just didn't work or made me tired.
But this drug made me feel like I was the most unhappy person in the world and that there is no hope for me.Is there someone who experienced an improvement after the 10th day or do you speak just theoretically?
Posted by Netch on September 25, 2009, at 3:22:14
In reply to Re: Agomelatine/Valdoxan for anxiety??, posted by Helena24 on September 24, 2009, at 15:09:39
If you are sensitive to agomelatine an option would be to lower dosage.
Posted by morganator on September 25, 2009, at 10:16:43
In reply to Re: Agomelatine/Valdoxan for anxiety?? » Helena24, posted by Netch on September 25, 2009, at 3:22:14
I have heard it takes 2 to 4 weeks for Ago to work.
You definitely seem to be hypersensitive to it for some reason. I don't really blame you for wanting to quit.
Posted by morganator on September 25, 2009, at 10:20:00
In reply to Re: Agomelatine/Valdoxan for anxiety??, posted by Helena24 on September 23, 2009, at 7:27:13
I wonder if it is possible that Ago is interacting with the high dose of tianeptine in a bad way that is specific to your chemistry.
Why not lower the tianeptine or ween off tianeptine and raise the Ago.
You may feel much better on Ago alone at 25 or 50 mgs. Besides, it doesn't sound like tianeptine is doing that much for you right now.
Posted by Sigismund on September 25, 2009, at 20:29:20
In reply to Re: Agomelatine/Valdoxan for anxiety??, posted by morganator on September 25, 2009, at 10:20:00
>I wonder if it is possible that Ago is interacting with the high dose of tianeptine in a bad way that is specific to your chemistry.
Combinations are unpredictable and hard to get right.
Since the effect of agomelatine and tianeptine have some similarity, I'm not surprised it didn't work out well.
Posted by Helena24 on September 26, 2009, at 11:38:33
In reply to Agomelatine/Valdoxan for anxiety??, posted by jms600 on September 21, 2009, at 6:38:51
"Take less of the tianeptine" is not so easy since it is a habit-forming drug.
Look at my thread about tianeptine addiction.http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20090921/msgs/918569.html#918569
Tianeptine raises dopamine in the nucleus accumbens.
Agomelatine raises DA and NE in the prefrontal cortex.
I was hoping to "augment" the tianeptine with the agomelatine /to "boost" it's effects.Agomelatine is also similar to mirtrazapine in some ways (5ht-receptor antagonism/increase of dopamine and norepinephrine in the prefrontal cortex).
In the past I had a bad reaction to mirtrazapine (the 2nd time I tried it) with agitation/dispair and emotional outburts.I took it with no other drug.
Perhaps I'm sensitive to this specific action of increased DA and NE in the PFC and/or 5ht2b/c receptor antagonism.
Maybe I try Ago again when I manage to come off the tianeptine.
In my oppinion tianeptine is much more effective than agomelatine.
Servier failed to draw the appropriate attention to it.
This is the end of the thread.
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