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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Jimmyboy on September 13, 2009, at 8:46:11
Hi can someone please tell me what seratonin receptors are involved in the blunting oif libido effect of seratonin elevating drugs?
Is it 5ht2-a and 5ht2-c? Either, both? If so, any ideas on the most prudent idea on how to block these receptors?
I have taken a 5ht2-a antagonist in the past ( nefazodone, trazodone) - both of these made me extremely drowsy and "out of it" . Is this an effect that is inherent to 5ht2-a antagonists? Or is it another effect of these drugs?
Thanks for any insight
Posted by linkadge on September 13, 2009, at 11:00:47
In reply to seratonin receptors and libido - help plz., posted by Jimmyboy on September 13, 2009, at 8:46:11
I'm not exactly sure. I know that 5-ht1a agonists have a facilitatory effect on certain aspects of sexual function.
5-ht2c antagonism supposedly reverses the negative effects of serotonin reuptake inhibition on sexual function. On the other hand, I think acute 5-ht2c agonism can facilitate certain aspects of sexual function (erection etc.)
Not sure about 5-ht2a. I know 5-ht2a agonism release oxytocin, so this might facilitate certain aspects of sexual function.
I think I remember reading that 5-ht2c antagonism and 5-ht2a agonism had synergistic effects on sexual function in some rodent model of sexual dysfunction.
OTOH, I think 5-ht2c agonism is what is responsible for the anti-premature ejaculation effects of SSRI's.
So, perhaps if ejaculation is premature, 5-ht2c agonism is beneficial, but if it is latent (or impossible) some degree of 5-ht2c antagonism is beneficial.
Linkadge
Posted by linkadge on September 13, 2009, at 11:21:09
In reply to Re: seratonin receptors and libido - help plz., posted by linkadge on September 13, 2009, at 11:00:47
I also remember reading that prolonged 5-ht1a agonism causes sexual dsyfunction (on account of inhibition of acetycholine function - and perhaps REM supression?)
I think this applies to most neurotransmitter systems. If the system is pulled too much in one direction it becomes dysfunctional. The yang is necesary in order for the ying to work properly.
Linkadge
This is the end of the thread.
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