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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by willyeee on September 11, 2009, at 12:03:33
I have read the numerous threads on parnate,i agree with scott,...and for people who dont feel well with the idea of HIGH PARNATE DOSES,....one thing you should know is PARNATES HALF LIFE IS 2.5 HOURS !!!!! My god almost feel off chair when i read that,that is a very very short time for a drug to be active.
Posted by Phillipa on September 11, 2009, at 12:28:39
In reply to Parnate dosage/no wonder, posted by willyeee on September 11, 2009, at 12:03:33
Willyee glad you didn't fall off the chair!!!! So what does this mean for you? I know you were questioning the parnate? Love Phillipa
Posted by SLS on September 11, 2009, at 12:43:18
In reply to Parnate dosage/no wonder, posted by willyeee on September 11, 2009, at 12:03:33
> I have read the numerous threads on parnate,i agree with scott,...and for people who dont feel well with the idea of HIGH PARNATE DOSES,....one thing you should know is PARNATES HALF LIFE IS 2.5 HOURS !!!!! My god almost feel off chair when i read that,that is a very very short time for a drug to be active.
I would just add that Parnate goes in, does its work, and then disappears within that 2.5 hours. That work is permanent, though. The MAO enzymes that it attaches to are disabled. It takes days before enough new MAO enzymes are produced to replace the old disabled ones.
Parnate has been shown to produce changes in neurotransmitter receptors at very high dosages (120+ mg) that it does not at lower dosages. These things do not depend on 100% MAO inhibition, as this percentage is obtained at lower dosages (60-80mg). This includes the downregulation of 5-HT2 serotonin receptors.
- Scott
Posted by Sunbath on September 11, 2009, at 14:09:26
In reply to Re: Parnate dosage/no wonder, posted by SLS on September 11, 2009, at 12:43:18
Hi again willyeee,
concerning your previous thread and your answer, am I right that you never tried any sedating 5ht2 antagonist/inverse agonist? Maybe this would help you? What about Trazodone or Amitriptyline?Good luck!!!
Posted by bleauberry on September 11, 2009, at 17:34:08
In reply to Parnate dosage/no wonder, posted by willyeee on September 11, 2009, at 12:03:33
Scott is correct. Within that short 2.5 hours, Parnate permanently shuts down MAO enzymes. They don't come back. Never will. The same enzymes that were shut down by Parnate in that 2.5 hours are still shut down 24 hours later, 48 hours later, even 72 hours later. We have to wait for new enzymes to be produced to replace them, which takes days. So even though Parnate is in and out real fast, the changes it made are longlasting, long past the time the drug itself is totally gone.
There are other mechanisms of Parnate not well understood. My guess is they are probably more directly related to dosage frequency and dosage halflives.
Posted by willyeee on September 12, 2009, at 0:21:07
In reply to Re: Parnate dosage/no wonder, posted by SLS on September 11, 2009, at 12:43:18
I stand corrected
Posted by willyeee on September 12, 2009, at 0:23:04
In reply to Re: Parnate dosage/no wonder, posted by Sunbath on September 11, 2009, at 14:09:26
> Hi again willyeee,
> concerning your previous thread and your answer, am I right that you never tried any sedating 5ht2 antagonist/inverse agonist? Maybe this would help you? What about Trazodone or Amitriptyline?
>
> Good luck!!!Please always feel free to comment,its what i seek from posting.
TRAZODONE had a horrid horrid dirty feel to it for me,yucky,Amitriptyline is one i have been curious about.
Posted by Sunbath on September 12, 2009, at 1:03:41
In reply to Re: Parnate dosage/no wonder, posted by willyeee on September 12, 2009, at 0:23:04
I agree with you about trazodone being somewhat dirty and I don't feel really good with it either! I also feel it's making me somewhat foggy during the day..
It's just the one that let's me sleep at night and doesn't cause any weight gain (now taking 175mg (of the XR version)) and I've gotten so used to it that I experience sever insomnia when I try to reduce the dose.. so I'm sticking with it for now as sleep is still an issue (much better though).. (maybe I can start reducing when (if) parnate has taken care of the anxiety...)Amitriptyline was even better for sleep, but it left me more tired during the day than trazodone and I was too scared about the weight gain..
I wish you all the best!!! If you haven't tried amitriptyline already then I'd think that there's big hope and if it's making you too tired, then there's still nortriptyline to try :)
This is the end of the thread.
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