Shown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Phillipa on August 18, 2009, at 0:20:30
Sounds like a winner Naltexone with morphine in pills for pain. Cuts Drug Abuse and Opens for new Pain control for arthritis and other causes. This is good. Love Phillipa
From Medscape Medical News
FDA Approves Morphine/Naltrexone to Treat Moderate to Severe Pain
Yael WaknineAuthors and Disclosures
August 14, 2009 The US Food and Drug Administration (FDA) has approved morphine sulfate and naltrexone hydrochloride extended-release capsules (Embeda, King Pharmaceuticals, Inc) for once- or twice-daily use in the management of moderate to severe pain when continuous, around-the-clock opioid analgesic therapy is warranted for an extended period.The capsules contain morphine pellets with a sequestered inner core of the opioid antagonist naltrexone that is released when the product is crushed or chewed, thereby discouraging tampering and drug abuse.
"The development of formulations like Embeda that employ technologies designed to reduce drug liking and euphoria associated with non-medical uses could potentially change how chronic pain is treated. Prescribers and patients have been hoping and waiting for safer medicines to treat chronic pain," said Nathaniel Katz, MD, president of analgesic research and adjunct assistant professor, Tufts University, Medford, Massachusetts, in a company news release.
Approval of the product was based on data from 12 clinical studies, including a phase 3 study showing that its use provided significant pain relief compared with placebo in patients with severe pain caused by osteoarthritis of the hip or knee.
Morphine/naltrexone capsules were well-tolerated in patients receiving up to 1 year of therapy, demonstrating an overall safety profile consistent with opioid drugs as a class. Adverse events included constipation, nausea, and somnolence.
Posted by yxibow on August 18, 2009, at 4:31:27
In reply to No More Opiod Abuse With New Combined Med???, posted by Phillipa on August 18, 2009, at 0:20:30
The intention may be right but the concept is revolting.
So someone in severe pain -- morphine sulfate is just about the last recourse, can have sudden and violent withdrawals if they accidentally chew their pills ???
WTF?
I mean it sounds as weird as putting a potent amount of flumazenil in a specially constructed capsule of Xanax and calling it NoXanabuse XL..
I don't know, I know opioids are abused but this seems inhumane somehow.-- Jay
Posted by Sigismund on August 18, 2009, at 15:39:10
In reply to No More Opiod Abuse With New Combined Med???, posted by Phillipa on August 18, 2009, at 0:20:30
This is an important issue.
God forbid that pain sufferers should feel illicit euphoria.
It is important to arrive in heaven sober.
>Prescribers and patients have been hoping and waiting for safer medicines to treat chronic pain,Prescribers certainly, but some of those patients are unreliable.
Posted by Sigismund on August 18, 2009, at 15:42:46
In reply to Re: No More Opiod Abuse With New Combined Med??? » Phillipa, posted by yxibow on August 18, 2009, at 4:31:27
In the event an inability to swallow, the patient could be given a suppository or, quite possibly some codeine linctus, should pain relief be indicated.
Those without teeth should have no reason to doubt the mercy and care of the state.
Posted by Sigismund on August 18, 2009, at 15:51:46
In reply to No More Opiod Abuse With New Combined Med???, posted by Phillipa on August 18, 2009, at 0:20:30
>The development of formulations like Embeda that employ technologies designed to reduce drug liking and euphoria associated with non-medical uses could potentially change how chronic pain is treated.
The technological fix has served our culture well and is, in large part, responsible for our present condition.
Posted by Phillipa on August 18, 2009, at 21:49:35
In reply to Re: No More Opiod Abuse With New Combined Med???, posted by Sigismund on August 18, 2009, at 15:39:10
I've heard that naltexalone just prevents abuse. Many methods of delivering pain meds Fentanyl patches, even Dilaudid patches. Phillipa
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