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Dr. Bob is Robert Hsiung, MD,
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Posted by lukh on May 14, 2009, at 6:41:49
Hi, I recently saw the Seroquel animation from its official site, saying that quetiapine improves both Da release and Na function (net). Does NET mean Reuptake like a NaRi such as reboxetine or just its release?What kind of mechanism for desalkyl-quetiapine?
I currently take daily 300x3 carbolithium, depakin 300+500, lamictal 25x2, seroquel XR 600 in the evening, zoloft 100 mgs and solian 50 mgsx2
Any info is appreciated,Luca
Posted by desolationrower on May 15, 2009, at 5:45:03
In reply to seroquel and dopamine/noradrenaline function, posted by lukh on May 14, 2009, at 6:41:49
q (or its metabolite) do two things related to this. reuptake, and antagonizing alpha2 adrenoceptors. both increase both catecholamines.
so kind of like reboxetine+mirtazapine or yohimbine.
-d/r
Posted by noidentity on May 15, 2009, at 8:11:39
In reply to seroquel and dopamine/noradrenaline function, posted by lukh on May 14, 2009, at 6:41:49
Additionaly there is 5HT2A and 5Ht2C Antagonism, which leads to dopamine release in the prefrontal cortex.
Markus
Posted by lukh on May 16, 2009, at 7:20:05
In reply to Re: seroquel and dopamine/noradrenaline function, posted by noidentity on May 15, 2009, at 8:11:39
Thank you a lot!
This is the end of the thread.
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