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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by tensor on May 7, 2009, at 2:20:51
Seeing my pdoc today. Have taken Edronax + Zoloft for weeks for major depression, when I started this combo I quit Remeron. Now I'm losing more energy every day, it's like I can't function without Remeron, even when depressed it does something, so I can at least exercise awhile in the morning, I can't do that now.
Would it be safe and rational to add Remeron to my current combo?/Mattias
Posted by SLS on May 7, 2009, at 5:14:18
In reply to What do you think of this combo?, posted by tensor on May 7, 2009, at 2:20:51
> Seeing my pdoc today. Have taken Edronax + Zoloft for weeks for major depression, when I started this combo I quit Remeron. Now I'm losing more energy every day, it's like I can't function without Remeron, even when depressed it does something, so I can at least exercise awhile in the morning, I can't do that now.
> Would it be safe and rational to add Remeron to my current combo?It is theoretically possible that adding Remeron to a NE reuptake inhibitor will act synergistically to increase activity in NE pathways. This might be a good thing. I saw only one report of serotonin syndrome involving a SSRI and Remeron.
Wait for other to chime in, but I can't think of any serious adverse events coming from this combination.
- Scott
Posted by Phillipa on May 7, 2009, at 11:56:06
In reply to Re: What do you think of this combo? » tensor, posted by SLS on May 7, 2009, at 5:14:18
Scott I didn't think remeron had serotonin? Phillipa
Posted by tensor on May 7, 2009, at 12:34:14
In reply to Re: What do you think of this combo? » SLS, posted by Phillipa on May 7, 2009, at 11:56:06
> Scott I didn't think remeron had serotonin? Phillipa
It boosts serotonin via a different mechanism than reuptake inhibition, the same goes for NE.
@Scott: Will ditch Zoloft and take Remeron + Edronax instead and see what that does for me.
/Mattias
Posted by bleauberry on May 7, 2009, at 15:26:37
In reply to Re: What do you think of this combo?, posted by tensor on May 7, 2009, at 12:34:14
> It boosts serotonin via a different mechanism than reuptake inhibition, the same goes for NE.
>
> @Scott: Will ditch Zoloft and take Remeron + Edronax instead and see what that does for me.
>
> /Mattias
>Since Remeron does not induce serotonin toxicity syndrome when combined with MAOIs, it is doubtful it has any meaningful effect on increasing serotonin. More than likely it is some other mechanism. It is primarily a super potent antihistamine compared to anything else it might do. The norepinephrine boost is also suspect, since it does not induce the typical signs of that...blood pressure, heart rate, etc.
But if it helps someone feel better, that is all that matters.
Posted by Zana on May 7, 2009, at 19:11:24
In reply to Re: What do you think of this combo?, posted by bleauberry on May 7, 2009, at 15:26:37
I take 45mgs of remeron and 50 mgs of pristiq without a problem.
Zana
Posted by tensor on May 8, 2009, at 3:31:05
In reply to Re: What do you think of this combo?, posted by Zana on May 7, 2009, at 19:11:24
> I take 45mgs of remeron and 50 mgs of pristiq without a problem.
>
> ZanaHow is Pristiq working? Is it alot different than Effexor? I think Effexor would be a good choice for me but I can't stand the side effects, is Pristiq better in this regard?
/Mattias
Posted by manic666 on May 8, 2009, at 12:19:12
In reply to What do you think of this combo?, posted by tensor on May 7, 2009, at 2:20:51
zoloft sure zaps you evergy levels , i think that the point of the med ,to slow you down from exploding,for me its one or the other
Posted by desolationrower on May 13, 2009, at 3:10:19
In reply to Re: What do you think of this combo?, posted by bleauberry on May 7, 2009, at 15:26:37
well it probably increases 5ht in a more regional/state specific way. and the 5ht2/3 blocking would mostly prevent 5ht toxicity too.
as for NA, the synergistic effect would probably be good, but i suppose you could also have too much, and have BP/somatic anxiety problems.
-d/r
Posted by mark1955 on May 17, 2009, at 15:33:33
In reply to Re: What do you think of this combo?, posted by Zana on May 7, 2009, at 19:11:24
Do you think the pristiq + remeron combo is as effective as effexor + remeron (California Rocket Fuel)?
Posted by miko84 on May 23, 2009, at 2:27:31
In reply to What do you think of this combo?, posted by tensor on May 7, 2009, at 2:20:51
My best combo: Wellbutrin+Oxybutynin.
Works on depression and social anxiety.
This is the end of the thread.
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