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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 19 of 19. This is the beginning of the thread.
Posted by Jeroen on March 24, 2009, at 15:37:59
Seroquel why did it work? experts, please
low dose made me recover from schizophrenia for a short time is 3 months, then i got tiredness, paranoia back
any theories? seroquel is the only med that worked for me, i tryed 6 Atypicals and its the only that workedi took 100 mg, and no more than that
Posted by yxibow on March 24, 2009, at 16:00:14
In reply to Seroquel why did it work? experts, please, posted by Jeroen on March 24, 2009, at 15:37:59
> Seroquel why did it work? experts, please
> low dose made me recover from schizophrenia for a short time is 3 months, then i got tiredness, paranoia back
>
>
> any theories? seroquel is the only med that worked for me, i tryed 6 Atypicals and its the only that worked
>
>
>
> i took 100 mg, and no more than that
I know you're searching for answers, Jeroen, but its hard to explain why certain medications work in certain people's bodies in one way and not in another.Seroquel doesnt quite work the same as it used to and did some unexpected things but is still of crucial value in my treatment. There's no real explanation why.
Genomic testing may explain why I metabolize things faster or slower but that's more of academic value, it is no predictor.
I thought the Abilify was 'working' for you. I don't like to put any downcast on things, but medication is only one part of the picture and practically nothing works 100% -- we all have slight genetic differences that are almost imperceptible that make that so.
Its painful for me to see psychosis like events daily 24/7, I never really thought that was part of my make-up, basically OCD. And that may play a twisted role in things as well as really bad insomnia.
-- best wishes
-- Jay
Posted by Jeroen on March 24, 2009, at 16:24:55
In reply to Re: Seroquel why did it work? experts, please » Jeroen, posted by yxibow on March 24, 2009, at 16:00:14
thanks
im gonna try Seroquel XR
who knows its more stable or something
Posted by Phillipa on March 24, 2009, at 16:30:30
In reply to yxibow, posted by Jeroen on March 24, 2009, at 16:24:55
Jeroen good idea.Love Phillipa who knows you may be on to something good for you
Posted by yxibow on March 24, 2009, at 19:14:37
In reply to yxibow, posted by Jeroen on March 24, 2009, at 16:24:55
> thanks
>
> im gonna try Seroquel XR
>
> who knows its more stable or somethingI tried it -- it is unclear if it caused a slightly greater weight gain or not. Otherwise, the only benefit was that it helped me with a tic that I have which gets worse at night.
Might help you with "peaks and valleys" where thte plasma level changes a little -- its not prescribed very often though because most psychiatrists still believe that regular Seroquel is not terribly different.
-- best wishes and luck
-- Jay
Posted by SLS on March 25, 2009, at 6:28:47
In reply to Seroquel why did it work? experts, please, posted by Jeroen on March 24, 2009, at 15:37:59
> Seroquel why did it work? experts, please
> low dose made me recover from schizophrenia for a short time is 3 months, then i got tiredness, paranoia backI am no expert. Not even close.
However,
I have seen a combination of Seroquel plus Risperdal relieve a woman of psychotic depression with paranoia and delusions. In this combination, much less Seroquel is needed to produce an energizing effect, and the Risperdal would probably mitigate the paranoia.
Theory? None, really. However, the energizing effect of Seroquel might be the result of its metabolite being a potent NE reuptake inhibitor (like desipramine). Risperdal binds to DA receptors much more tightly than does Seroquel and is probably better at mitigating delusions and paranoia. I suggest that the combination might represent complementary mechanisms that for you, might help both with energy and paranoia.
- Scott
Posted by nellie7 on March 25, 2009, at 16:04:16
In reply to Re: Seroquel why did it work? experts, please » Jeroen, posted by SLS on March 25, 2009, at 6:28:47
> > Seroquel why did it work? experts, please
> > low dose made me recover from schizophrenia for a short time is 3 months, then i got tiredness, paranoia back
>
> I am no expert. Not even close.
>
> However,
>
> I have seen a combination of Seroquel plus Risperdal relieve a woman of psychotic depression with paranoia and delusions. In this combination, much less Seroquel is needed to produce an energizing effect, and the Risperdal would probably mitigate the paranoia.
>
> Theory? None, really. However, the energizing effect of Seroquel might be the result of its metabolite being a potent NE reuptake inhibitor (like desipramine). Risperdal binds to DA receptors much more tightly than does Seroquel and is probably better at mitigating delusions and paranoia. I suggest that the combination might represent complementary mechanisms that for you, might help both with energy and paranoia.
>
>
> - Scottseroquel for energizing? i thought this med was known to cause severe drowsiness:)
Posted by nellie7 on March 25, 2009, at 16:06:13
In reply to Re: Seroquel why did it work? experts, please, posted by nellie7 on March 25, 2009, at 16:04:16
Posted by SLS on March 26, 2009, at 5:52:31
In reply to Re: Seroquel why did it work? experts, please, posted by nellie7 on March 25, 2009, at 16:04:16
> seroquel for energizing? i thought this med was known to cause severe drowsiness:)
Generally, at dosages of 25-100mg, I see somnolence (profound sleepiness) as the primary effect. As the dosage is increased, Seroquel treatment can result in activation and produce antidepressant effects. Of course, not everyone reacts to this drug the same way.
- Scott
Posted by nellie7 on March 26, 2009, at 11:22:00
In reply to Re: Seroquel why did it work? experts, please » nellie7, posted by SLS on March 26, 2009, at 5:52:31
> > seroquel for energizing? i thought this med was known to cause severe drowsiness:)
>
> Generally, at dosages of 25-100mg, I see somnolence (profound sleepiness) as the primary effect. As the dosage is increased, Seroquel treatment can result in activation and produce antidepressant effects. Of course, not everyone reacts to this drug the same way.
>
>
> - ScottThanks for clearing that up, Scott.
Posted by bleauberry on March 26, 2009, at 17:45:19
In reply to Seroquel why did it work? experts, please, posted by Jeroen on March 24, 2009, at 15:37:59
And while I absolutely totally agree with SLS on a seroquel-risperdal combo, I would also like to reiterate something I have mentioned several times over several months but it seems to be ignored. That is, combine a tricyclic antidepressant with your seroquel. Clomipramine, amitriptyline, nortriptyline, desipramine are the choices. I certainly am no expert or doctor, but if I had to make a choice, I would go with Amitriptyline or Clomipramine, and reserve the others if side effects were too harsh.
I only keep harping on the idea of an AP/TCA combo because when I just surf around at pubmed I keep finding good case reports of it in cases that sound very similar to yours.
If you are looking for hard science to back up your med choice, forget it. You've already tried the best hard science has to offer. You have to go with anecdotal evidence, real world observations, and case reports. That's where the TCA/AP thing comes in.
Posted by linkadge on March 26, 2009, at 19:05:02
In reply to Re: Seroquel why did it work? experts, please, posted by bleauberry on March 26, 2009, at 17:45:19
I don't mean to sound blunt, but come on Jaroen. Its been every other post for the past 3 years on this board. Seroquel worked and now it doesn't.
I hate to sound blunt but get over it.
Thanks for blocking me. But I had to say it.
Linkadge
Posted by yxibow on March 26, 2009, at 19:21:54
In reply to Re: Give up on the seroquel already holy-crap, posted by linkadge on March 26, 2009, at 19:05:02
Well -- I'm sure Jeroen is suffering in ways we can't imagine. It is hard to "get over it". It is unfortunate that the state medicine doesn't pay for or has not seen for some sort of psychological counseling which I think would be invaluable.
The first part of coming to terms with a serious illness is anger, and then there is denial. I know this because I have a pretty serious syndrome which has had impossible to predict iatrogenic consequences.
And so psychological therapy which I also wrestle with it too, has been a large part of a "recovery model"
I understand your feelings -- I too have seen Jeroen go through what might be considered a merry-go-ground of medications that defy what would be considered Western protocols (in a fairly advanced country) for longer trials of medication.
But there is a certain yearning, and I've felt it too to come to have taken most medication combinations, that the next one will work, or why especially has the Seroquel that I take for a different condition fallen short now of what it should.
But I try to bite my tongue... I think a little too much on here about civility to the point of self-censoring everything... but I'll leave that for another discussion on why I feel trapped in what I can say.
I have advised Jeroen numerous times to stick to a particular medication for a longer period of time, that the benefits outweigh the risks, or that that has to be balanced. But below that psychosis which may or may not cloud someone's thought, there is a life there.
Sometimes I just don't say anything because that's better.
Anyhow, that is my extent of talking about someone in the third person.-- Jay
Posted by Jeroen on March 26, 2009, at 21:39:00
In reply to Re: illnesses, posted by yxibow on March 26, 2009, at 19:21:54
Seroquel XR is the last thing i will try, if not working ill add memantine ill ask my doctor
Posted by yxibow on March 26, 2009, at 22:49:39
In reply to Seroquel XR, posted by Jeroen on March 26, 2009, at 21:39:00
> Seroquel XR is the last thing i will try, if not working ill add memantine ill ask my doctor
I'm still not sure on the memantine angle -- it carries some anxiety risks and other things.
At any rate, if you do try the XR, give it at least a month and a half if not more, please, unless there's something really bad happening. Because you'll never know with a week's trial
-- best wishes
Jay
Posted by Deputy 10derHeart on March 27, 2009, at 2:56:26
In reply to Re: Give up on the seroquel already holy-crap, posted by linkadge on March 26, 2009, at 19:05:02
>Give up on the seroquel already holy-crap
>Its been every other post for the past 3 years on this board
> get over it.Please be sensitive to the feelings of others by not posting anything that could lead them to feel accused or put down, and by not posting exaggerations about their posting habits.
As you were asked to be civil very recently on this board, I am going to block you from posting for 2 weeks. Dr. Bob will review the length of the block at some point, and he of course, may change the length as he sees fit.
> Thanks for blocking me.Well, I won't say 'you're welcome' - that just doesn't work for me.
>But I had to say it.
We all make choices about what to post, and sometimes they come with certain consequences, as you know. I'm sorry it had to lead down this road, where I myself *don't* like to take us...
Link, I would much rather have your valuable voice around here than have you blocked. Take care of yourself.
- 10derHeart, acting as deputy to Dr. Bob
Posted by Jeroen on March 27, 2009, at 3:22:03
In reply to Re: Seroquel XR » Jeroen, posted by yxibow on March 26, 2009, at 22:49:39
to Deputy please unblock linkadge
i didnt feel insulted in any way
Posted by myco on March 27, 2009, at 11:41:44
In reply to Blocked for 2 weeks » linkadge, posted by Deputy 10derHeart on March 27, 2009, at 2:56:26
Linkadge has alot of valuable insite that people here can use. I dont agree with an outburst but we dont know what state of mind he was in when saying that (I know all about irritability)...perhaps a warning....he was only being straight up or blunt in opinion.
> >Give up on the seroquel already holy-crap
> >Its been every other post for the past 3 years on this board
> > get over it.
>
> Please be sensitive to the feelings of others by not posting anything that could lead them to feel accused or put down, and by not posting exaggerations about their posting habits.
>
> As you were asked to be civil very recently on this board, I am going to block you from posting for 2 weeks. Dr. Bob will review the length of the block at some point, and he of course, may change the length as he sees fit.
>
> > Thanks for blocking me.
>
> Well, I won't say 'you're welcome' - that just doesn't work for me.
>
> >But I had to say it.
>
> We all make choices about what to post, and sometimes they come with certain consequences, as you know. I'm sorry it had to lead down this road, where I myself *don't* like to take us...
>
> Link, I would much rather have your valuable voice around here than have you blocked. Take care of yourself.
>
> - 10derHeart, acting as deputy to Dr. Bob
>
>
>
Posted by Deputy 10derHeart on March 28, 2009, at 5:18:04
In reply to to Deputy please unblock linkadge, posted by Jeroen on March 27, 2009, at 3:22:03
I responded over on Admin - here's a link:
http://www.dr-bob.org/babble/admin/20090302/msgs/887362.html
This is the end of the thread.
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