![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by cable1234 on March 20, 2009, at 16:16:50
Is it still available/prescribed in the US?
Posted by yxibow on March 20, 2009, at 19:08:35
In reply to Reserpine--Do They Still Prescribe It?, posted by cable1234 on March 20, 2009, at 16:16:50
> Is it still available/prescribed in the US?
Its still available although listed in the orange book is BP, meaning it has some bioavailability problems. Generally Ax labeled drugs are equivalent.
But that really isn't the issue -- its a medicine with some fairly high risky potentials.
There are much better recent atypicals or some of the less strong typical APs.
It is a dopamine depleter, tetrabenazine is a better choice for a very narrow issue, normally for huntington's, but sometimes used in tardive cases with some liability.
I doubt it is prescribed very often. It also is an old heart medication
-- Jay
Posted by linkadge on March 20, 2009, at 19:47:02
In reply to Re: Reserpine--Do They Still Prescribe It? » cable1234, posted by yxibow on March 20, 2009, at 19:08:35
Doesn't reserpine also deplete serotonin and norepinephrine? There is some research suggesting that it had some AD augmentative effect when patients were pretreated with it before TCA therapy.
Linkadge
Posted by cable1234 on March 22, 2009, at 10:09:19
In reply to Re: Reserpine--Do They Still Prescribe It? » cable1234, posted by yxibow on March 20, 2009, at 19:08:35
> > Is it still available/prescribed in the US?
>
> Its still available although listed in the orange book is BP, meaning it has some bioavailability problems. Generally Ax labeled drugs are equivalent.
>
> But that really isn't the issue -- its a medicine with some fairly high risky potentials.
>
> There are much better recent atypicals or some of the less strong typical APs.
>
> It is a dopamine depleter, tetrabenazine is a better choice for a very narrow issue, normally for huntington's, but sometimes used in tardive cases with some liability.
>
> I doubt it is prescribed very often. It also is an old heart medication
>
> -- JayWell I have real bad tardive akathisia. They say it can help.
Posted by yxibow on March 22, 2009, at 14:58:33
In reply to Re: Reserpine--Do They Still Prescribe It?, posted by cable1234 on March 22, 2009, at 10:09:19
> Well I have real bad tardive akathisia. They say it can help.Well that may be an indication -- don't forget though the benefits have to outweigh the risks, reserpine can cause TD and TDy.
Tetrabenazine (Xenaxine) is cleaner, although it is harder to obtain since it is an orphan drug now on the market in the US, doesn't carry quite the liability, but it still can do it. Tetrabenazine also carries a long term risk of pseudoparkinsomism.
I wish you luck with your informed choices.
There is also Clozaril which carries its own restrictive blood monitoring but carries a near zero risk of TD and a low risk of TDy as other agents.
-- Jay
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.