![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by Jay_Bravest_Face on November 27, 2008, at 0:24:22
I read this article on the history of opioids. One researcher made a great, funny comment. He said Oxycodone(sp?) makes you feel so good you want to phone the telephone company and tell them what a great job they are doing!
Jay :)
Posted by sam K on November 27, 2008, at 0:38:01
In reply to Great comment on Opioids, posted by Jay_Bravest_Face on November 27, 2008, at 0:24:22
its true indeed
I am a former addict, and the addict side of me say MAN DO I LOVE PAIN KILLERS!!!!! WOO HOO lol. it makes me feel good just thinking about them. They make me feel great...
Posted by Sigismund on November 27, 2008, at 2:56:41
In reply to Great comment on Opioids, posted by Jay_Bravest_Face on November 27, 2008, at 0:24:22
I think the Jewish chemist who developed oxycodone was murdered by the Nazis.
How come that (for example) in Australia....
diamorphine was available OTC in unit doses
Opium was available OTC in much larger doses
Morphine was available OTC (ditto).....
before 1968?How come??
There was not an unmanageable problem before then.
So we changed?
Posted by iforgotmypassword on November 27, 2008, at 4:53:47
In reply to Great comment on Opioids, posted by Jay_Bravest_Face on November 27, 2008, at 0:24:22
Posted by Phillipa on November 27, 2008, at 23:50:31
In reply to Re: Great comment on Opioids, posted by Sigismund on November 27, 2008, at 2:56:41
Experienced the same thing on percocet only one a day. So if opiod responsive any meds that docs would prescribe? Seriously Love Phillipa
Posted by Jay_Bravest_Face on November 28, 2008, at 2:03:46
In reply to Re: Great comment on Opioids, posted by Sigismund on November 27, 2008, at 2:56:41
Actually I use T3's (Tylenol 3's...with codeine)
daily. Nowhere near Oxycodone, but I can easily bump myself out of that "dread" with them. Plus, I take Lyrica, and combining the two makes for a nice gentle sleep. I've been using T3's for about 9 years, not *everyday* straight, and my liver/kidney function is always fine. So, Sig, I can't answer your question...sorry..heh. I'd netter get some sleep....oh...and p.s. I have *never* increased my Tylenol3 dose.Thanks..
Jay
Posted by Jay_Bravest_Face on November 28, 2008, at 2:16:17
In reply to that quote is indeed precious. link to article? (nm) » Jay_Bravest_Face, posted by iforgotmypassword on November 27, 2008, at 4:53:47
I think it was on one of those pro-drug recreation websites. I'll have to look in my history.
Posted by Jay_Bravest_Face on November 28, 2008, at 2:22:03
In reply to Re: Great comment on Opioids, posted by Phillipa on November 27, 2008, at 23:50:31
Well, there are some Rx-happy doctors here in Ontario. These drugs are not really monitored, at least in no way like having to make triplicates of scripts, and send them to the Narc-squad. Just our Pharmacists who may give you a bit of a hard time if you are going through tankloads of this stuff. Okay..now I gotta go to bed...thank you and goooooooooooooooooooooooooooodddddddddniiiiiiiiiiiiiiiiight! :-)
Jay
Posted by Sigismund on November 28, 2008, at 13:30:18
In reply to Re: Great comment on Opioids »sam K » Sigismund, posted by Jay_Bravest_Face on November 28, 2008, at 2:03:46
Either
we turned into a lot of irresponsible pleasure seekers
or
we got taken over by people with issues relating to control
or
we all turned into nut cases.
Posted by Jimmyboy on November 28, 2008, at 16:29:31
In reply to Re: Great comment on Opioids » Jay_Bravest_Face, posted by Sigismund on November 28, 2008, at 13:30:18
Interesting article on mu-opiod receptors and response to anti-depressants..
http://www.psychiatrictimes.com/display/article/10168/1153657?pageNumber=2
Summary
"Substantial evidence in rodents exists to support the role of the µ-opioid system in antidepressant response and the pathophysiology of depressive-like symptoms. In humans, the placebo effect is clearly mediated by the µ-opioid system, which potentially explains a portion of the response seen with many pharmaceuticals. Furthermore, the present data also suggest a role in antidepressant response and tolerance, as well as remission from major depression in humans. The interindividual differences in variations in the OPRM1 gene, and the associations described above, have implications in personalized medicine. One could imagine selecting one antidepressant over another based on genotypic constitution, and predictability of response rate, tolerance to the particular medication. Together this body of literature points to a new direction for research into novel antidepressant treatments and the pathology of MDD."
Posted by Bobby on November 28, 2008, at 21:06:17
In reply to Great comment on Opioids, posted by Jay_Bravest_Face on November 27, 2008, at 0:24:22
..in the medicine cabinet. An interesting exercise in self control---the pull is unearthly. I no longer have a toothache--or do I?
Posted by Sigismund on November 28, 2008, at 21:17:50
In reply to I have a near full bottle of Percocets.., posted by Bobby on November 28, 2008, at 21:06:17
Even as a child in the late 1950s I would take the odd aspirin because it was written on the label 'For sleeplessness due to pain' (such touching hope), so the rot must have set in by then.
Posted by bulldog2 on November 29, 2008, at 12:30:37
In reply to Re: Great comment on Opioids, posted by Phillipa on November 27, 2008, at 23:50:31
> Experienced the same thing on percocet only one a day. So if opiod responsive any meds that docs would prescribe? Seriously Love Phillipa
Than you would become addicted again as you worked so hard to detoxify from them.
Posted by Phillipa on November 29, 2008, at 18:10:35
In reply to Re: Great comment on Opioids, posted by bulldog2 on November 29, 2008, at 12:30:37
I know I did you're right darn. Love Phillipa
Posted by Neal on December 4, 2008, at 1:10:25
In reply to Re: Great comment on Opioids » bulldog2, posted by Phillipa on November 29, 2008, at 18:10:35
I commented elsewhere that opioids were the only med for depression for thousands of years. Yes, depressed people were "addicts", but so what. There's always the lunatic fringe that misuses things, but why that drives policy I don't know.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.