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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Marty on October 22, 2008, at 23:07:16
I'm curious to know how 5-HT2c antagonism in Prozac makes it different from other SSRIs. Anyone tried many SSRIs and can see a difference between Prozac and the other ?Would you characterize this difference please ?
This would be interesting as Agomelatine, a new AD, main mechanism of action is 5-HT2c antagonism (+ melatoninergic agonism)....
/\/\arty
Posted by Phillipa on October 22, 2008, at 23:34:04
In reply to Prozac vs Other SSRIs: Any difference ? plz share, posted by Marty on October 22, 2008, at 23:07:16
Marty have taken them all and prozac when I wasn't anxious or depressed by day three was in sheer panic attacks stopped then and three days of xanax to get back to baseline. All the others were activating also except luvox and tired on celexa when first came out. And always combined with benzos low doses. Love Phillipa
Posted by azalea on October 22, 2008, at 23:40:32
In reply to Prozac vs Other SSRIs: Any difference ? plz share, posted by Marty on October 22, 2008, at 23:07:16
I believe the 5HT2C antagonism is theorized to explain why Prozac is quite activating, especially upon initiation of treatment.
>
> I'm curious to know how 5-HT2c antagonism in Prozac makes it different from other SSRIs. Anyone tried many SSRIs and can see a difference between Prozac and the other ?
>
> Would you characterize this difference please ?
>
> This would be interesting as Agomelatine, a new AD, main mechanism of action is 5-HT2c antagonism (+ melatoninergic agonism)....
>
> /\/\arty
Posted by Trotter on October 25, 2008, at 13:36:51
In reply to Prozac vs Other SSRIs: Any difference ? plz share, posted by Marty on October 22, 2008, at 23:07:16
I did not experience Prozac as unique in any way from the other SSRIs. I had slightly different reactions to them all, but mainly just variations in the intensity of side effects. Insomnia and sexual side effects were average. AD response was average.
Posted by ricker on October 25, 2008, at 17:21:10
In reply to Prozac vs Other SSRIs: Any difference ? plz share, posted by Marty on October 22, 2008, at 23:07:16
I had a brief trial of prozac n 1989. Diagnosis at the time was depression, anxiety... I have never been diagnosed with psychosis, a-typical or other. Started on Prozac along with pimozole?. 7 -10 days and I was like a caged lion. Have never experienced such feelings..went into bathroom, stared into mirror, grabbed razor and began cutting wrist!
Totally not me?? Back to hospital to get stabilized. To this day I'm not sure if it was the prozac or pimozole. I probably will never know as those 2 drugs have been permanently removed from my "lets try again" list. :(
Have tried every ssri and zoloft has/is working best along with lamicatal and low dose clonazepam.
It is a mystery how one's miracle drug is anothers nightmare?
Regards, Rick
Posted by Marty on October 25, 2008, at 18:35:00
In reply to Re: Prozac vs Other SSRIs: Any difference ? plz share » Marty, posted by ricker on October 25, 2008, at 17:21:10
> pimozole?. 7 -10 days and I was like a caged lion. Have never experienced such feelings..went into bathroom, stared into mirror, grabbed razor and began cutting wrist!
---It's Pimozide and what you've been through is called AKATHISIA. Here's an extract from wikipedia about Pimozide being the worst inducer of akathisia:
"In particular, pimozide is known for causing the unpleasant extrapyramidal side-effect akathisia (commonly referred to as "restless pacing") in a large percentage of those who take it. This "restlessness" can sometimes be treated with anticholinergic drugs (mainly benztropine), beta blockers or benzodiazepines, particularly clonazepam (Klonopin). Unfortunately, in many cases this side effect can be so intense that even large doses of these drugs are unable to counter it, and often is so extreme that self-destructive behaviour, including attempting suicide, may occur."
I've done a little episode of Akathisia and it's exactly how you put it: a caged lion, but claustrophobic and on amphetamine. Quite the nightmare.
That said, it's best advised not to try Prozac again since you'll never be sure at 100% how much it contributed.
Akathesia on Wikipedia: http://en.wikipedia.org/wiki/Akathisia
/\/\arty
Posted by ricker on October 26, 2008, at 11:48:32
In reply to Re: Prozac vs Other SSRIs: Any difference ? plz s » ricker, posted by Marty on October 25, 2008, at 18:35:00
Unfortunately, in many cases this side effect can be so intense that even large doses of these drugs are unable to counter it, and often is so extreme that self-destructive behaviour, including attempting suicide, may occur."
Wow! that would certainly explain my reaction?!
> I've done a little episode of Akathisia and it's exactly how you put it: a caged lion, but claustrophobic and on amphetamine. Quite the nightmare.Yes, of all the side effects over the years with various meds, nothing comes close to that. Funny my pdoc at the time never mentioned akathisia?
> That said, it's best advised not to try Prozac again since you'll never be sure at 100% how much it contributed.Yes I agree, although with my luck, Prozac would probably be my wonder drug!
Regards, Rick
Posted by Marty on October 26, 2008, at 15:39:46
In reply to Re: Prozac vs Other SSRIs: Any difference ? plz s » Marty, posted by ricker on October 26, 2008, at 11:48:32
> Yes I agree, although with my luck, Prozac would probably be my wonder drug!
---
If you think it could be the case then maybe you could try it in an appropriate setup:
- VERY low dose.
- NEVER be let alone.
- STOP at first sign of Akathisia.
- GO straight to ER with the person who's with you.You know how it feels and how you reacted.. this time wouldn't be like the last one if you take precautions.
Prozac may be an option if you don't know what to try next. It's just a question of setup to protect yourself.
/\/\arty
Posted by ricker on October 26, 2008, at 19:21:04
In reply to Re: Prozac vs Other SSRIs: Any difference ? plz s » ricker, posted by Marty on October 26, 2008, at 15:39:46
Marty, thanks for your input. I don't mean to go off topic with your prozac thread, but, :-) at my last pdoc appointment, anti-psychotics were mentioned by my pdoc if the lamictal fails. Because I had such a bad experience with the pimozide, does that mean I would experience akathasia to the saame degree with Geodon or Seroquel? I don't believe Abilify is available here in Canada. Thanks again for any input.
Rick
Posted by Marty on October 26, 2008, at 20:19:06
In reply to Re: Prozac vs Other SSRIs: Any difference ? plz s » Marty, posted by ricker on October 26, 2008, at 19:21:04
> does that mean I would experience akathasia to the saame degree with Geodon or Seroquel?
---
I wouldn't bet on it. That said, if you were to try one I suggest you go with small dose Seroquel first as it is one of the weaker antipsychotic. Also I would apply the same preventive setup that with the potential Prozac trial.> I don't believe Abilify is available here in Canada.
---
Abilify isn't approved in Canada yet and I'm not aware of it being approve in the next few months. Also Geodon in Canada is called Zeldox. Zeldox at low dose act more like an antidepressant than like an antipsychotic: dopamine antagonism kicks in at mid-dosage./\/\arty
Posted by ricker on October 26, 2008, at 22:33:07
In reply to Re: Prozac vs Other SSRIs: Any difference ? plz s » ricker, posted by Marty on October 26, 2008, at 20:19:06
This is the end of the thread.
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