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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by desolationrower on September 15, 2008, at 23:57:17
I've been on it a few days. This stuff is like legal pot. I feel super foggy, hard to concentrate, but have a stupid grin on my face. Also crazy dry mouth.
It does seem to be much stronger than the selegiline.
-D/R
Posted by djmmm on September 16, 2008, at 6:37:22
In reply to Tranylcypromine: WTF?, posted by desolationrower on September 15, 2008, at 23:57:17
> I've been on it a few days. This stuff is like legal pot. I feel super foggy, hard to concentrate, but have a stupid grin on my face. Also crazy dry mouth.
>
> It does seem to be much stronger than the selegiline.
> -D/Rgeneric Parnate... how much did you take? Your reaction is interesting.. For me, it's stimulating.
Posted by desolationrower on September 16, 2008, at 9:58:50
In reply to Re: Tranylcypromine: WTF?, posted by djmmm on September 16, 2008, at 6:37:22
I take 40mg. 30mg in the morning and 10 mg in the afternoon.
-D/R
Posted by James_Glasgow_UK on September 17, 2008, at 14:04:14
In reply to Re: Tranylcypromine: WTF?, posted by desolationrower on September 16, 2008, at 9:58:50
I got the same reaction initially my mouth was so dry I could hardly speak. After a while you will probably find your weight going down and not being able to sleep without a strong sedative.
Posted by desolationrower on September 21, 2008, at 19:38:06
In reply to Re: Tranylcypromine: WTF?, posted by James_Glasgow_UK on September 17, 2008, at 14:04:14
The dry mouth isn't so bad. I don't feel quite so goofy. I still feel kind of foggy, but not as bad. When i sleep, I sleep very well, for exactly a sleep cycle. Then i wake up, when i should go into REM sleep. I can go bad to sleep very easily. This happens several times, and i get 6 hours of sleep easily. 8 hours if am willing to lie in bed for a half hour or so. I also can't get an erection and libido is down. I feel sort of stuffed up in my lower gut i wonder if it is not ejaculating for an entire week. So far it is a great antidepressant. I hope it continues, i feel like life is worth livign.
I am taking
40mg tranylcypromine
.25mg risperidone
600mg NAC
600mg magnesium
10mg elemental lithium (240 li orotate)
1g ALCAR
3 g epa+dha
1g vitamin c
2000 iu vitamin d3
45 vitamin k2
b complex, multivitamin, 800mcg folate, occasional b12 sublingual (very tasty!)
i alternate gabapentin and benedryl for sleep. i need to get something else, i just didn't realize i might need something with the tcp.-D/R
Posted by desolationrower on September 22, 2008, at 19:15:19
In reply to TCP: week 1, posted by desolationrower on September 21, 2008, at 19:38:06
I think i might start memantine before i increase the dose. I don't want to lose effect.
oh i forgot, i take creatine and on some days 600mg adrafinil.
-D/R
Posted by desolationrower on September 22, 2008, at 19:19:51
In reply to Re: TCP: week 1, posted by desolationrower on September 22, 2008, at 19:15:19
Whoah. I guess it makes sense the more i think about it.
Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome.
Nisijima K, Shioda K, Yoshino T, Takano K, Kato S.Department of Psychiatry, Jichi Medical School, Kawachi-Gun, Tochigi-Ken, 329-0498, Japan. psychiat@jichi.ac.jp
BACKGROUND: Serotonin (5-HT) syndrome is the most serious side effect of antidepressants. Although several drugs have been used for the treatment of 5-HT syndrome, a universal pharmacotherapy has not been established. NMDA receptor antagonists have been reported to have neuroprotective effects. In the present study, the efficacy of NMDA antagonists, including memantine and MK-801, and potent 5-HT (2A) antagonists, including risperidone and ketanserin, was evaluated in a 5-HT syndrome animal model. METHODS: 5-Hydroxy-l-tryptophan (100 mg/kg) and clorgyline (2 mg/kg) were administered intraperitoneally in rats to induce 5-HT syndrome. The rectal temperature of the rats was measured, and the noradrenaline (NA) and 5-HT levels in the anterior hypothalamus were measured using a microdialysis technique. RESULTS: In the group pretreated with saline, the rectal temperature increased to more than 40 degrees C, and all of the animals died within 90 min of the drug's administration. The NA and 5-HT levels in the anterior hypothalamus increased to about 15- and 1100-fold of the pre-administration levels, respectively. Pretreatment with risperidone (0.5 mg/kg) and ketanserin (5 mg/kg) prevented the development of hyperthermia and the increase in the NA level. Memantine (10 mg/kg) and MK-801 (0.5 mg/kg) also prevented the development of hyperthermia and the increase in the NA level. These results suggest that NMDA antagonists, as well as potent 5-HT (2A) antagonists, may be effective drugs for the treatment of 5-HT syndrome. CONCLUSIONS: Since memantine is clinically well tolerated, this drug is a particularly promising therapeutic drug for 5-HT syndrome treatment.
-D/R
Posted by yxibow on September 23, 2008, at 1:28:23
In reply to memantine: it prevents serotonin syndrome, posted by desolationrower on September 22, 2008, at 19:19:51
Interesting journal note, but do take note that this is in rats, they were treated with Risperdal, ketanserin, which is a biological drug not marketed but to labs and is a potent 5HT blocker, and a small amount of MK-801 which never came to market because of problems in the brain and probably also because it was recreational like ketamine which also involves NMDA, was used along with memantine.
And not everyone's experience with memantine is innocuous -- it can cause confusion in some.
For myself, it did wierd things once I reached 20mg, made my disorder completely outside the box to the point of thinking "this is just wrong." Ceased memantine, and it stopped. Which was unfortunate because it was one trial to get some of my short term memory loss due to benzodiazepine usage back.
Now of course, that's my experience -- may your experience with Namenda be better.
-- tidingsJay
Posted by desolationrower on October 3, 2008, at 13:59:20
In reply to Re: memantine: it prevents serotonin syndrome » desolationrower, posted by yxibow on September 23, 2008, at 1:28:23
Update, i think its been three weeks total as of tomorow: talked with pdoc, agreed i should go up to 60mg. It seems to be very effective for depression. I lost my job this week, and wasn't too upset. It might be helping slightly now with social anxiet. I still have been waking up during the night on occasion, although only once or twice; trazodone and cyproheptadine seem about the same for that (i'd wake up 5/6 times without). sleep feels very refreshing though. Some sexual function seems to be returning, as is overall energy.
-d/r
Posted by iforgotmypassword on March 31, 2012, at 6:56:41
In reply to memantine: it prevents serotonin syndrome, posted by desolationrower on September 22, 2008, at 19:19:51
we have to remember how low our dosages typically are. most of us take 20mg or less... i think there is a product coming out normalising 27mg or something in some combo $$$ brandname preparation. 10mg/kg is gigantic, i know this a new post, but i need some means of tagging somewhere here that it tends to be these studies with very high doses that we see protection vs extreme drug/neurotransmitter effects. i would wonder if the typical low 20mg memantine + amp/adderall is more neurotoxic to subcortical dopaminergic neurons that we need to supplement with other things, not just rely on what (while amazing) is merely fending off tolerance at that dose. i don't think they necessarily confirm the existence of the other (tolerance mitigation, dopaminergic toxicity mitigation) i have gone back to this combo, with alcar, with ala, with creatine (a bit/need to work on dosing), with vit c, with melatonin. i think these help. i may think try to brainstorm what else may be helpful. this is relevant as i think while alcar helps it doesn't outright prevent my getting into aimless loops and cluttered confused movement trouble which i think are associated with hyperthermia. memantine i think would have to be at a much higher dose to help me, and esp. as someone whose movement problems seemed to begin with the SSRIs. maybe time to look at clonidine, idk. anyway, sorry for pasting this here, kinda took the liberty since this was so old, yet i figured my observations were really important, unvoiced elsewhere (that i could easily find at least).
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