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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by robbieboy74 on August 15, 2008, at 11:33:53
So guys! Does anyone know if grapefruit juice INCREASES or DECREASES the effects of methadone?
What about provigil?
What happens if you take methadone WITH provigil?
What about lamictal? Does that do anything?
I am prescribed lamictal and provigil and recently started methadone for...pain. I really want to know if they interact with each other, and also how they interact when grapefruit is thrown into the picture.
Posted by sunnydays on August 15, 2008, at 13:10:58
In reply to METHADONE + GRAPEFRUIT JUICE (AND OTHERS), posted by robbieboy74 on August 15, 2008, at 11:33:53
I'm not positive, but grapefruit juice often decreases the effectiveness of a lot of drugs or has no effect - nothing I've heard about increasing effectiveness.
sunnydays
Posted by robbieboy74 on August 15, 2008, at 16:42:34
In reply to METHADONE + GRAPEFRUIT JUICE (AND OTHERS), posted by robbieboy74 on August 15, 2008, at 11:33:53
Please someone help!
Posted by Phoenix1 on August 15, 2008, at 19:01:57
In reply to METHADONE + GRAPEFRUIT JUICE (AND OTHERS), posted by robbieboy74 on August 15, 2008, at 11:33:53
This should help with regards to methadone:
http://www.ncbi.nlm.nih.gov/pubmed/15229464> So guys! Does anyone know if grapefruit juice INCREASES or DECREASES the effects of methadone?
>
> What about provigil?
>
> What happens if you take methadone WITH provigil?
>
> What about lamictal? Does that do anything?
>
> I am prescribed lamictal and provigil and recently started methadone for...pain. I really want to know if they interact with each other, and also how they interact when grapefruit is thrown into the picture.
Posted by robbieboy74 on August 16, 2008, at 23:56:53
In reply to Re: METHADONE + GRAPEFRUIT JUICE (AND OTHERS) » robbieboy74, posted by Phoenix1 on August 15, 2008, at 19:01:57
thx! n e 1 know about the others?
Posted by kingcolon on September 5, 2008, at 14:10:59
In reply to METHADONE + GRAPEFRUIT JUICE (AND OTHERS), posted by robbieboy74 on August 15, 2008, at 11:33:53
>
Provigil is a weak inducer of CYP3A4. Since methadone is metabolized by CYP3A, Provigil should somewhat decrease methadone levels. I have read literature of Provigil being used with opioids to counter the side effects of sedation, and there seems to be no clinically important interaction. I use buprenorphine, which is also metabolized by CYP3A, as well as Provigil, and the two seem OK together for me.
So guys! Does anyone know if grapefruit juice INCREASES or DECREASES the effects of methadone?
>
> What about provigil?
>
> What happens if you take methadone WITH provigil?
>
> What about lamictal? Does that do anything?
>
> I am prescribed lamictal and provigil and recently started methadone for...pain. I really want to know if they interact with each other, and also how they interact when grapefruit is thrown into the picture.
Posted by paulboston on September 6, 2008, at 20:59:08
In reply to Re: METHADONE + GRAPEFRUIT JUICE (AND OTHERS) » robbieboy74, posted by kingcolon on September 5, 2008, at 14:10:59
Robbie-
only white grape fruit juice will increase your levels of methadone and also antacids will also do the same. google addiction forum for a list of meds the plus and minus methadone levels. This website is owned by one of the drug companies of methadone.
Take care,
Paul
Posted by Alfred G Land on February 25, 2015, at 17:19:04
In reply to Re: METHADONE + GRAPEFRUIT JUICE (AND OTHERS) » robbieboy74, posted by kingcolon on September 5, 2008, at 14:10:59
Modfanil induces CYP 3A4 which metabolizes methadone. Using modafinil on a regular basis will cause methadone to be metabolized much more regularly.
In my experience, 110 mg methadone HCl/day would last long enough that I could miss a day's dose without much problem.
After five or six days of 400 mg modafinil/day, methadone would wear off so quickly that I would be sick within 24 hours due to methadone abstinence syndrome.
Posted by Alfred G Land on February 25, 2015, at 17:20:43
In reply to Re: METHADONE + GRAPEFRUIT JUICE (AND OTHERS), posted by Alfred G Land on February 25, 2015, at 17:19:04
Sorry, I said that using modafinil regulary would case methadone to be metabolized much more "regularly" but I meant much more "quickly."
Methadone is a strong CYP 3A4 inducer.
This is the end of the thread.
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