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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by B2chica on August 14, 2008, at 13:32:26
i know i'm not getting responses from questions of pristiq cuz no ones probably on it but i have one more question.
if pristiq is a metabolite of Effexor(ER?)
and the properites of Effexor are:
5-HT reuptake inhibition +++
NE reuptake inhibition ++
DA reuptake inhibition +would pristiq's properites be the same?
Posted by dcruik518 on August 14, 2008, at 15:50:41
In reply to PRISTIQ and Metabolite/properties, posted by B2chica on August 14, 2008, at 13:32:26
I'm on Pristiq. To me it feels much milder and more tolerable than effexor; that may be because of the lower dose they recommend. I wouldn't think the reuptake properties would be markedly different, but it's too soon to say. ~Dwight
Posted by Larry Hoover on August 14, 2008, at 18:08:40
In reply to PRISTIQ and Metabolite/properties, posted by B2chica on August 14, 2008, at 13:32:26
> i know i'm not getting responses from questions of pristiq cuz no ones probably on it but i have one more question.
>
> if pristiq is a metabolite of Effexor(ER?)
> and the properites of Effexor are:
> 5-HT reuptake inhibition +++
> NE reuptake inhibition ++
> DA reuptake inhibition +
>
> would pristiq's properites be the same?Pristiq is O-desmethylvenlafaxine, the product of the P450 enzyme 2D6 acting on venlafaxine (Effexor). The activity of the 2D6 enzyme is highly variable, so Pristiq bypasses this concern altogether. People who can't effectively metabolize Effexor at 2D6 are much more likely to have intolerable GI side-effects, and others.
As for binding affinities, Pristiq is similar at the 5-HT transporter, slightly stronger at the NE transporter, and has almost no effect at the dopamine transporter.
One significant difference in the two drugs is half-life. Effexor is listed at ~5 hours, whereas Pristiq is ~11. Pristiq is also relatively slowly absorbed, hitting Tmax (highest blood concentration) 7.5 hours after ingestion. So, you're much less likely to suffer from peak/trough concentration fluctuations.
Best,
Lar
Posted by copper on August 17, 2008, at 15:33:14
In reply to Re: PRISTIQ and Metabolite/properties » B2chica, posted by Larry Hoover on August 14, 2008, at 18:08:40
I have been on this med now for 5 days at50 mg, was on effexor 225mg for about 5 years. It started to slowly stop working.
On pristiq I have not felt any relief as of yet.Copper
Posted by B2chica on August 20, 2008, at 8:03:01
In reply to Re: PRISTIQ and Metabolite/properties, posted by copper on August 17, 2008, at 15:33:14
any weight gain on pristiq?
Posted by B2chica on August 20, 2008, at 8:03:42
In reply to Re: PRISTIQ and weight, posted by B2chica on August 20, 2008, at 8:03:01
Posted by dcruik518 on August 20, 2008, at 16:54:01
In reply to wrong place sorry (nm), posted by B2chica on August 20, 2008, at 8:03:42
I have not noticed any noticeable weight gain on Pristiq, whereas I did gain quite a bit on Effexor.
Posted by copper on August 20, 2008, at 20:32:17
In reply to Re: wrong place sorry, posted by dcruik518 on August 20, 2008, at 16:54:01
I have not noticed any difference on pristiq. I also am on remeron which I have to really watch my weight on. My pdoc told me to take pepcid with the remeron as it blocks the h2 receptor.
Copper
This is the end of the thread.
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