Shown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by linkadge on July 30, 2008, at 21:59:03
http://cat.inist.fr/?aModele=afficheN&cpsidt=17912073
Linkadge
Posted by linkadge on July 30, 2008, at 22:01:39
In reply to Nicotine blocks stress induced BDNF drop, posted by linkadge on July 30, 2008, at 21:59:03
Linkadge
Posted by linkadge on July 30, 2008, at 22:03:46
In reply to Re: Nicotine boosts BDNF release, posted by linkadge on July 30, 2008, at 22:01:39
Linkadge
Posted by Marty on July 30, 2008, at 22:11:13
In reply to Re: Nicotine boosts BDNF release, posted by linkadge on July 30, 2008, at 22:01:39
Interesting Link.
Would you think the effect is significant enough for someone to add to his cocktail 'the patch' ?I don't know where you live, but in Canada the only place in gov building where you can smoke is in psychiatric hospital where they all have a ventilated 'smoking' room for patients. Pdocs told me it was because it has always been known that reducing/stoping depressed patients smoking habits very often resulted into worsening of condition... this is obvious for many reasons but your post just added another one I guess.
/\/\arty
Posted by Sky Brite Line on July 31, 2008, at 0:53:36
In reply to Re: Nicotine boosts BDNF release » linkadge, posted by Marty on July 30, 2008, at 22:11:13
maybe thats why i smoke so much in car.......its late.
Posted by linkadge on July 31, 2008, at 8:05:42
In reply to Re: Nicotine boosts BDNF release » linkadge, posted by Marty on July 30, 2008, at 22:11:13
I didn't realize they still allowed smoking indoors for inpatients! Thats wierd. Yes, its banned almost everywhere here in Ontario.
Well, of course the issue is very controversial as you get the anti-smoking bandwagon and all the propegand that they associate with smoking. Yes smoking is bad, but that doesn't necessarily negatively implicate every constituent in tobacco smoke.
If you look at independant studies on nicotine itself, there seems to have a number of interesting properties.
I can't say how it will affect you so I don't know if it would be a good idea to add to your regiment. You could try. It might be a viable neuroprotective strategy.
Unlike most some drugs of abuse, nicotine seems to enhance reward sensitivity over time. It increases the expression of d3 receptors in the neucleus accumbens.
http://biopsychiatry.com/nicotine-dopamined3.htm
This might be very helpful for somebody who had good results with say a dopamine agonist, but who loses effect over time. Perhaps a low dose of nicotine + mirapex might be a good strategy to maintain an effect.
Linkadge
Posted by Phillipa on July 31, 2008, at 9:33:20
In reply to Re: Nicotine boosts BDNF release » Marty, posted by linkadge on July 31, 2008, at 8:05:42
Here smoking not all in buildings outside if not on restrictions ie: safety issues or new admission think first 24 hours. Phillipa
Posted by Marty on July 31, 2008, at 10:05:02
In reply to Re: Nicotine boosts BDNF release » Marty, posted by linkadge on July 31, 2008, at 8:05:42
> I didn't realize they still allowed smoking indoors for inpatients! Thats wierd. Yes, its banned almost everywhere here in Ontario.
---
Also banned in Ontario hospital psychiatric ward ? (only in psychiatric ward/ER btw) .. maybe it's not in all the provinces after all./\/\arty
Posted by linkadge on July 31, 2008, at 11:31:27
In reply to Re: Nicotine boosts BDNF release » linkadge, posted by Marty on July 31, 2008, at 10:05:02
>Also banned in Ontario hospital psychiatric >ward ? (only in psychiatric ward/ER btw) .. >maybe it's not in all the provinces after all.
That I don't know. I havn't been to one since the laws were altered:)
Linkadge
Posted by bleauberry on July 31, 2008, at 19:15:17
In reply to Nicotine blocks stress induced BDNF drop, posted by linkadge on July 30, 2008, at 21:59:03
I rely on nicotine but I can't tell you why. It is not the addiction to it. It is something else. I can't put my finger on it or describe it in words.
I get more benefit in terms of energy and mood boost from the gum than I do smoke. I think the carbon monoxide and other stuff in smoke kind of counteracts the good parts of nicotine. Whether it is BDNF or whatever, I have no idea. I just instinctively know it is "something".
Posted by linkadge on July 31, 2008, at 20:15:50
In reply to Re: Nicotine blocks stress induced BDNF drop, posted by bleauberry on July 31, 2008, at 19:15:17
It alsmost feels like a mood stabilizer in myself. It has a very strong 'thought glue'
like effect, it kind of slows things down.
Linkadge
Posted by desolationrower on July 31, 2008, at 21:31:26
In reply to Re: Nicotine blocks stress induced BDNF drop, posted by linkadge on July 31, 2008, at 20:15:50
I like nicotine for concentration at work, i suck on the mint flavoured tabs. I do not feel any benefit when i smoke though, although the smoking ritual is fun. Nicotine is the best thing for concentration over the counter.
Posted by Iansf on August 2, 2008, at 19:10:09
In reply to Nicotine blocks stress induced BDNF drop, posted by linkadge on July 30, 2008, at 21:59:03
Could you possibly provide a summary of these studies in layman's terms. I had difficultly figuring out what the studies were indicating. Thanks.
Ian
Posted by linkadge on August 2, 2008, at 20:26:28
In reply to Re: Nicotine blocks stress induced BDNF drop » linkadge, posted by Iansf on August 2, 2008, at 19:10:09
Well, I don't know if its the best recomendation *yet* for depressed individuals to consume nicotine (as there would need to be more studies to confirm these findings), but the articles seem to suggest a few things.
BDNF is a brain growth agent, like a neural fertilizer that appears to be low in people with depression. When BDNF levels are low, brain cells may not proliferate properly and can die. Agents capable of increasing BDNF, or in preventing the ability of stress to lower BDNF seem to have antidepressant potential.
These studies suggest that nicotine seems to protect against the ability of stress to lower BDNF levels and that it may increase BDNF synthesis and release in the hippocampus.
Nicotine was assumed at one point to cause depression (probably because people like to lump everything associated with smoking into one basket). More recent data however, suggests that it may infact have an antidepressant effect (through the modulation of BDNF and perhaps other growth factors like VEGF) and that is why depressed people smoke.
Anyhow, nicotine is probably not right for everbody, just something to think about.
Linkadge
Posted by Marty on August 2, 2008, at 22:03:06
In reply to Re: Nicotine blocks stress induced BDNF drop » Iansf, posted by linkadge on August 2, 2008, at 20:26:28
I'd like to add the obvious: Smoking never wins the risks/benefits ratio even if it means it could help in depression. That said if someone would like to try Nicotine to see if it helps, gum and patch are the ways.
I'm gonna buy some in the next couple days and report if it's of any help in my specific case./\/\arty
Posted by WhatToDoNext on August 3, 2008, at 16:11:44
In reply to Re: Nicotine blocks stress induced BDNF drop » linkadge, posted by Marty on August 2, 2008, at 22:03:06
I smoke 1 ppd and it does nothing for my anxiety or depression. Just thought I'd add my two cents.
Before I developed this disorder, smoking would seem to calm me down in stressful situations. So maybe my anxiety is so strong that I can't feel the calming effect of the nicotine.
Steve
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