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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by iforgotmypassword on June 21, 2008, at 19:10:45
quote from article: "Therefore, agents (e.g., NAC) that can increase brain GSH levels should be considered potential therapeutic drugs for negative symptoms in schizophrenia."
any other supplements or medications that raise brain glutathione? my symptoms are very negative symptom like (e.g. executive dysfunction, avolition, loss of feeling, blunted fluency, low cognitive stamina) which was the theory of my last doctor who diagnosed "Psychotic Disorder NOS"
i imagine many other people here have syndromes with predominant negative-like symptoms.
i also have a very screwy permanent extrapyramidal syndrome, which NAC, or raising brain glutathione, may also help.
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Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18398470
Posted by bleauberry on June 21, 2008, at 20:03:44
In reply to neg correlation between brain glutathione + neg sx, posted by iforgotmypassword on June 21, 2008, at 19:10:45
Another supplement to consider for increasing glutathione is ImmunePro RX. It is simply an expensive whey protein powder, but very different than other whey protein powders. It has not been subjected to heat. Heat destroys the natural cysteine, which is a primary building block of glutathione. It is a more natural and gentler way to increase cysteine and glutathione than NAC. NAC can sometimes be a bit too heavy, or too destabilizing than natural cysteine. These are not necessarily my own opinions, but rather general agreements from people at heavy metal chelation forums where cysteine/glutathione are major topics.
Mercury and lead disrupt the biochemical mechanisms that produce glutathione. While symptoms span the entire medical textbook and differ from person to person, common psychiatric symptoms of heavy metal disruption look like negative symptoms of schizophrenia...social withdrawal, anhedonia, depression. One of glutathiones function is to remove low level natural daily exposure to toxins. But when the toxic level is more than normal, it actually shuts glutathione down, making the toxicity even worse and symptoms worse. The whole process is very slow and deceptive, over years and decades. I am of the belief that many psychiatric patients actually have an unknown mercury component as the major player.
I won't get into the chelation stuff as that is very long and detailed. Just to say that supplementing extra cysteine can help over-ride mercury's influence and get glutathione levels back to where they should be.
Anyway, to increase glutathione, NAC is an option. ImmunePro Rx which supplies pure natural cysteine that is otherwise destroyed in most foods or supplements by heat is another option.
Posted by Tomatheus on June 21, 2008, at 22:32:52
In reply to neg correlation between brain glutathione + neg sx, posted by iforgotmypassword on June 21, 2008, at 19:10:45
> any other supplements or medications that raise brain glutathione?
Theoretically, vitamin B6 might increase glutathione levels. B6 helps convert homocysteine to glutathione via a process called transsulfuration.
> my symptoms are very negative symptom like (e.g. executive dysfunction, avolition, loss of feeling, blunted fluency, low cognitive stamina) which was the theory of my last doctor who diagnosed "Psychotic Disorder NOS"
>
> i imagine many other people here have syndromes with predominant negative-like symptoms.I do have strong negative symptoms, but the positive symptoms and depressive symptoms that I experience are also bothersome (my diagnosis is schizoaffective disorder). So, in my case, I wouldn't say that either positive symptoms or negative symptoms are predominant over the other. But I definitely know how troubling and disabling negative symptoms can be, and I certainly don't doubt that there are others who are negative-symptom dominant.
Tomatheus
Posted by dbc on June 21, 2008, at 22:48:35
In reply to Re: neg correlation between brain glutathione + ne » iforgotmypassword, posted by Tomatheus on June 21, 2008, at 22:32:52
Glutamate and all of its metabolites are soon to be the hot new thing. There was a huge article i think in the new york times that says pfizer has a new glutamate drug for schizophrenia that doesnt involve d2 antagonism. There was other talk of possible depression drugs blahblah.
Posted by Tomatheus on June 21, 2008, at 22:56:41
In reply to Re: neg correlation between brain glutathione + ne, posted by dbc on June 21, 2008, at 22:48:35
> Glutamate and all of its metabolites are soon to be the hot new thing. There was a huge article i think in the new york times that says pfizer has a new glutamate drug for schizophrenia that doesnt involve d2 antagonism.
Yeah, that's what I've heard, as well. I for one am certainly looking forward to the introduction of one of these third-generation antipsychotics.
Tomatheus
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