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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by deniseuk190466 on January 18, 2008, at 7:44:36
Hi,
How many people on this board have tried Riluzole and with what affects. I know Scott has to know avail (it made his depression worse), I see that Rovers 95 tried it but not sure what the final result was and that Dreamer tried it again not sure what the final result was.
Also, I see some people comparing Riluzole to Lamictal because (I think) they both act on the glutamate system.
I am still toying with this idea of trying to get onto a Ketamine to Riluzole/placebo trial but the stuff I've read so far about personal experiences with Riluzole does not look very promising.
I've also tried Lamictal and although it was quite sedating for me I didn't really find it very good as an antidepressant and before anyone asks when I first tried Lamictal I was on it for about 3 months so I did give it a good try.
Just wondering what peoples verdict of Riluzole is and how it compares with Lamictal.
Thanks.....Denise
Posted by SLS on January 18, 2008, at 8:44:47
In reply to Riluzole Lamictal questions, posted by deniseuk190466 on January 18, 2008, at 7:44:36
Hi Denise.
For me, the addition of riluzole to Lamictal was not at all helpful. The only impact it made was on my precription plan. It is prohibitively expensive.
I don't want to get too theoretical here, but riluzole and Lamictal impact glutamatergic neurons in opposite ways.
1. Lamictal - glutamate release inhibitor.
2. riluzole - glutamate release enhancer.
I don't know whether these seemingly opposite mechanisms would effectively prevent a response.I don't want to guarantee that the combination of these two drugs will produce no response or interact in ways that might actually make some people feel worse.
- Scott
Posted by deniseuk190466 on January 21, 2008, at 6:37:46
In reply to Re: Riluzole Lamictal questions » deniseuk190466, posted by SLS on January 18, 2008, at 8:44:47
Thanks Scott. I suppose the only way I'll ever find out is if I go ahead and try it.
I was really asking because I'm more interested in Ketamine and because of this Ketamine trial they are doing.
I was wondering how Riluzole would maintain a response to Ketamine when so far the verdicts I have seen on Riluzole as an antideppressant aren't that great.
Denise
Posted by deniseuk190466 on January 21, 2008, at 14:53:33
In reply to Re: Riluzole Lamictal questions, posted by deniseuk190466 on January 21, 2008, at 6:37:46
Anybody else out there who has tried Riluzole and with what results?
Denise
Posted by kingcolon on January 26, 2008, at 23:31:17
In reply to Re: Riluzole Lamictal questions » deniseuk190466, posted by SLS on January 18, 2008, at 8:44:47
> Hi Denise.
>
> For me, the addition of riluzole to Lamictal was not at all helpful. The only impact it made was on my precription plan. It is prohibitively expensive.
>
> I don't want to get too theoretical here, but riluzole and Lamictal impact glutamatergic neurons in opposite ways.
>
> 1. Lamictal - glutamate release inhibitor.
> 2. riluzole - glutamate release enhancer.
>
>
> I don't know whether these seemingly opposite mechanisms would effectively prevent a response.
>
> I don't want to guarantee that the combination of these two drugs will produce no response or interact in ways that might actually make some people feel worse.
>
>
> - Scott
>
> My reading about riluzole seems to indicate that it is an antiglutamatergic agent, not a glutamate enhancer, similar to Lamictal. This is from the article below:Consistent with a model of excessive glutamate-induced excitation in mood disorders, several antiglutamatergic agents, such as riluzole and lamotrigine, have demonstrated potential antidepressant efficacy.
Posted by Dr. Bob on January 28, 2008, at 5:12:24
In reply to Re: Riluzole Lamictal questions, posted by kingcolon on January 26, 2008, at 23:31:17
> Consistent with a model of excessive glutamate-induced excitation in mood disorders, several antiglutamatergic agents, such as riluzole and lamotrigine, have demonstrated potential antidepressant efficacy.
Sorry to interrupt, but I'd like to redirect follow-ups regarding excessive glutamate-induced excitation to the new Psycho-Babble Neurotransmitters board. Here's a link:
http://www.dr-bob.org/babble/neuro/20080114/msgs/809296.html
Thanks,
Bob
This is the end of the thread.
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