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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by DanielJ on November 20, 2007, at 10:18:47
Some months ago, after switching from Zyprexa to Risperdal, our Pdoc suggested that Invega was now available and was a "Time Release" version of Risperdal. We tried it first in 6 mg and then in 3 mg versions for a couple of months. Uh Ohh! this stuff caused my son to have intense depression and suicidal ideations. Be aware if you or someone you know starts taking Invega that the effects of this medication should be closely monitored. My son has been safely back on Zyprexa and Zoloft for 2 months, be wary of Invega.
Posted by Phillipa on November 20, 2007, at 11:32:46
In reply to Invega Warning, posted by DanielJ on November 20, 2007, at 10:18:47
Hi Daniel remember you and your Son. Invega is a new long acting version of resperidol? So what is your poor Son on now and hope it's working. Phillipa
Posted by kaleidoscope on November 20, 2007, at 13:33:46
In reply to Invega Warning, posted by DanielJ on November 20, 2007, at 10:18:47
Interesting.... but it is difficult to know whether the depression was actually caused by Invega, or whether it was due to the withdrawal of Zyprexa. Zyprexa is a drug with many withdrawal symptoms.
Posted by DanielJ on November 23, 2007, at 10:58:56
In reply to Invega Warning, posted by DanielJ on November 20, 2007, at 10:18:47
Not Zyprexa withdrawal, He quit all meds for a week or more and suicidal depression was gone in 2 days. Later he found he wanted to go back on meds so we went back on 12.5 mg Zyprexa and 100 mg Zoloft. Things have been pretty stable for the last month or so. He is still in college.
Posted by Zyprexa on November 27, 2007, at 14:29:17
In reply to Invega Warning, posted by DanielJ on November 20, 2007, at 10:18:47
I had similar problems with risperdal. Only zyprexa works for me. Glad I did not try invega! I was under the impression that it was only LIKE risperdal, not the same thing plus extended release.
Posted by yxibow on November 27, 2007, at 15:35:26
In reply to Re: Invega Warning, posted by Zyprexa on November 27, 2007, at 14:29:17
> I had similar problems with risperdal. Only zyprexa works for me. Glad I did not try invega! I was under the impression that it was only LIKE risperdal, not the same thing plus extended release.
Invega is the metabolite of Risperdal and is 50% as strong. Otherwise you're right, its a partial patent extend.
Posted by Zyprexa on November 28, 2007, at 10:42:05
In reply to Re: Invega Warning » Zyprexa, posted by yxibow on November 27, 2007, at 15:35:26
Please explain. What is a metabolite, is it a modified version. And which is only 50% as effective, the new version? Ie, which is more effective?
Thanks
Posted by yxibow on November 30, 2007, at 4:05:19
In reply to Re: Invega Warning » yxibow, posted by Zyprexa on November 28, 2007, at 10:42:05
> Please explain. What is a metabolite, is it a modified version. And which is only 50% as effective, the new version? Ie, which is more effective?
>
> ThanksNot 50% as effective, 50% as immediate. When you ingest Risperdal, your body converts it to paliperidone (Invega) and other side metabolites are largely unused psychotropically. So Janssen wanted to keep Risperdal around so they did a me-too (mostly) patent extension and lo and behold paliperidone. There hasn't been a truly "novel" atypical since Abilify and that didn't remove some of the side effects that were predicted.
Well, we're waiting since Thorazine for a TD-free agent and Seroquel is about as close as we've come save for Clozaril which has caveats and has no 100.000% percent guarantees although nobody to date has heard of a journal provable Clozaril-only taker movement syndrome in particular. In fact it improves things often.
I think we'll be waiting another several decades at least, continuing the history for 75 years of antipsychotics. But who knows.
This is the end of the thread.
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