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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by linkadge on November 13, 2007, at 19:51:52
Hi, venlafaxine helps, but I can't get over the chest tightness it produces. It feels like something is contricting my coronary artery not to mention strange erratic pulse.
Hard to describe.
Not that I need to go through withdrawl, I just feel like I know better, and I don't really want to discuss it with doctors.
Anyhow. I don't want to mess with the heart.
Maybe one day they'll make effective drugs that are also safe.
Linkadge
Posted by torachan on November 13, 2007, at 20:42:06
In reply to Venlafaxine, I think I am coming off, posted by linkadge on November 13, 2007, at 19:51:52
Trust your body, I'd say, assuming you have no history of hypochondria. Hypochondria must be difficult to diagnose; "doctor, I think I'm losing my mind" to which the doctor responds, "Oh, it's all in your head."
Posted by Phillipa on November 14, 2007, at 0:52:15
In reply to Re: Venlafaxine, I think I am coming off, posted by torachan on November 13, 2007, at 20:42:06
Link no don't mess with your heart I'd go off it to. May be the bodies ways of saying not the right med for you? Phillipa
Posted by tecknohed on November 14, 2007, at 8:15:17
In reply to Venlafaxine, I think I am coming off, posted by linkadge on November 13, 2007, at 19:51:52
Are you planning on trying another AD? NRI perhapse? You should be able to switch strait to an NRI, though you'd probably get a rapid heart beat at first (esp. if a tricyclic) but that'll fade with time.
Posted by Sigismund on November 14, 2007, at 12:43:16
In reply to Re: Venlafaxine, I think I am coming off, posted by torachan on November 13, 2007, at 20:42:06
Doctor, I think I'm losing my mind.
Oh, it's all in your head.
If only it was.
Posted by linkadge on November 14, 2007, at 13:26:14
In reply to Re: Venlafaxine, I think I am coming off » linkadge, posted by tecknohed on November 14, 2007, at 8:15:17
I would like to try a NRI. I had more sucess with straterra as an AD than I did with SSRI's.
Its not so much rapid heartbeat that bothers me, more that I get this strange tightness in my chest.
I never got it with straterra or TCA's.
Linkadge
Posted by tecknohed on November 14, 2007, at 16:16:03
In reply to Re: Venlafaxine, I think I am coming off » tecknohed, posted by linkadge on November 14, 2007, at 13:26:14
> I would like to try a NRI. I had more sucess with straterra as an AD than I did with SSRI's.
>
> Its not so much rapid heartbeat that bothers me, more that I get this strange tightness in my chest.
>
> I never got it with straterra or TCA's.
>
> LinkadgeDesipramine then? If its anything like lofepramine (which it should be) then you'll love it! Lofepramine took 3 weeks for me each time, though some benifits were felt much earlier on (energy & motivation). Its the mood lift that takes the longest.
Carefull if you have anxiety or agitation.
Reboxetine was similar except with VERY LITTLE mood lift. Even became quite tearfull in the end which is why I stopped. But we're all different I guess.
Posted by Racer on November 15, 2007, at 1:10:44
In reply to Re: Venlafaxine, I think I am coming off » tecknohed, posted by linkadge on November 14, 2007, at 13:26:14
> I would like to try a NRI. I had more sucess with straterra as an AD than I did with SSRI's.
>
>
> I never got it with straterra or TCA's.
>
> LinkadgeStrattera seemed like a good AD for me, too, and it's one I might try again, too. Are you seriously considering it? It sounds like a good plan, since you wouldn't have the side effect that scared me most...
Posted by Jedi on November 15, 2007, at 2:52:20
In reply to Venlafaxine, I think I am coming off, posted by linkadge on November 13, 2007, at 19:51:52
Hi Link,
I remember that venlafaxine helped somewhat with my depression. But it also raised my BP to an unacceptable level. I tried adding pindolol to it, to lower the BP and augment the antidepressant effect; didn't seem to work to well.I currently take 90mg of Nardil, which controls my depression and social anxiety disorder; plus it lowers my borderline high blood pressure. I don't have to take another BP med, everyone else in my family does.
Take care,
Jedi
> Hi, venlafaxine helps, but I can't get over the chest tightness it produces. It feels like something is contricting my coronary artery not to mention strange erratic pulse.
>
> Hard to describe.
>
> Not that I need to go through withdrawl, I just feel like I know better, and I don't really want to discuss it with doctors.
>
> Anyhow. I don't want to mess with the heart.
>
> Maybe one day they'll make effective drugs that are also safe.
>
> Linkadge
>
>
>
Posted by linkadge on November 15, 2007, at 20:14:22
In reply to Re: Venlafaxine, I think I am coming off » linkadge, posted by Jedi on November 15, 2007, at 2:52:20
Yeah, there is something strange about venlafaxine. For the supposedly low amount of norepiniephrine reuptake inhibition, I shouldn't have had high blood pressure.
I took straterra at 40mg and did not have high blood pressure.
Linkadge
Posted by florence on November 17, 2007, at 21:28:39
In reply to Re: Venlafaxine, I think I am coming off, posted by linkadge on November 15, 2007, at 20:14:22
Link,
Per SLS's Psych and Related Drugs:
Venlafaxine- (Effexor,Efexor, Trevilor, Vandral): cyclohexanol: SNRI 5HT reuptake inhibition+++; NE reuptake inhibition++; DA reuptake inhibition+
Per pt insert sheet on Effexor XR:
Effexor XR is an extended-release capsule for oral administration that contains venlafaxine hydrochloride, a structurally novel AD. It is designated (R/S)-1 {2-(dimethylamino)-1- (4-methoxyphenlethyl} cyclohexanol hydrochloride or +-1(alpha- dimethy;amino) methyl} p-methoxybenzyl} cyclohexanol hydrochloride and has the empirical formula of C17H27NO2 hydrochloride.
"The mechanism of the AD action of venl. in humans is believed to be assoc. with its potentiation os neurotransmitter activity in the CNS. Preclinical studies have shown that venla. and its active metabolite O-desmethylvenlafaxine (ODV) are POTENT INHIBITORS of neuronal serontonin AND NE reuptake and weak inhib. of DA reuptake. .... In VITRO no significant affinity for muscarinic cholinergic H1 histaminergic or A1 (alpha 1 ?? I assume) adrenergic receptors...
Strattera med guide: non-stimulant med used to treat ADHD in children, teenagers and adults...
..contains Atomoxetine hydrochloride a SELECTIVE NE reuptake inhibitor...I have taken both. Strattera called a "clean drug" by dr. Both put me to sleep. Don't know what it is NE selective for: lost that page from Scott's SLS med guide.
High blood pressure might occur in either drug. Maybe Strat is beta ?? Just know that Sudafed- OTC pseudoephedrine is an alpha agonist: so can raise blood pressure or heart rate..
Sorry too out of it to doube check post.. Need to recopy Scott's med guide- which I use with pt insert that u have to ASK for at drug store unless it comes with sample meds.. So I can check liver enzymes that are induced or inhibited since drs know nil...i better stop. FDA has drug info sheet if u go to their website.
Also, i got weird "chest pains" w/drawing from Klonopin, Provigil, ....It's a feeling that goes all up my sternum and also feels like my chest muscles are being stretched apart....Not my heart. That just beats weird.....Have read this alot all over; if u drink coffee or take caffeine they say it's worse.... florence
***********************************8
Yeah, there is something strange about venlafaxine. For the supposedly low amount of norepiniephrine reuptake inhibition, I shouldn't have had high blood pressure.
>
> I took straterra at 40mg and did not have high blood pressure.
>
> Linkadge
This is the end of the thread.
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