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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by deniseuk190466 on September 18, 2007, at 15:06:09
Speedier Anti-Depressants May Hit The Shelves
A new study has shed more light on how the medication ketamine, when used experimentally for depression, relieves symptoms of the disorder in hours instead of the weeks or months that current antidepressants take to work.
While ketamine itself maybe won't come into use as an antidepressant because of its side effects, the new finding takes scientists significantly closer to understanding how to build up faster-acting antidepressant medications, reports the study by the National Institute of Mental Health (NIMH), part of the National Institutes of Health.An earlier NIMH study in humans had shown that Ketamine blocks a receptor called NMDA on brain cells, but the new study in mice shows that this is a midway step. It turns out that blocking NMDA increases the activity of another receptor, AMPA, and that this boost in AMPA is crucial for ketamine's rapid antidepressant actions.
"Our research is showing us how to develop medications that get at the biological roots of depression. This new finding is a major step toward learning how to improve treatment for the millions of Americans with this debilitating disorder; toward eliminating the weeks of suffering and uncertainty they have to endure while they wait for their medications to work," said NIH Director Elias Zerhouni, M.D.
By aiming new medications at more direct molecular targets, such as NMDA or AMPA, scientists may be able to evade some of the steps through which current antidepressants indirectly apply their effects.
Denise
Posted by seldomseen on September 18, 2007, at 18:23:48
In reply to New study on Ketamine - Incase you've not seen, posted by deniseuk190466 on September 18, 2007, at 15:06:09
If any one is interested.
Posted by rovers95 on September 19, 2007, at 10:41:23
In reply to New study on Ketamine - Incase you've not seen, posted by deniseuk190466 on September 18, 2007, at 15:06:09
Is there anything out there that can boost AMPA receptors???!!!
rover
Posted by deniseuk190466 on September 24, 2007, at 13:39:44
In reply to NIMH is recruiting patients for a phase II trial, posted by seldomseen on September 18, 2007, at 18:23:48
For the people on the trial for whom it helps, what do they say "oh well it helped you a lot but we are only giving this as part of a trial, so off you go now and carrying on living your depressed life until we've managed to develop some drugs (which could be another 10 years) which can be used clinically?
Denise
Posted by rovers95 on October 2, 2007, at 11:17:45
In reply to The thing about this ketamine trial., posted by deniseuk190466 on September 24, 2007, at 13:39:44
> For the people on the trial for whom it helps, what do they say "oh well it helped you a lot but we are only giving this as part of a trial, so off you go now and carrying on living your depressed life until we've managed to develop some drugs (which could be another 10 years) which can be used clinically?
>
>
> Denisehttp://www.southcoasttoday.com/apps/pbcs.dll/article?AID=/20070909/LIFE/709090331/-1/LIFE01
This article suggests that there are drugs beind developed that act like ketamine, by companies such pfizer.......so perhaps there is hope and progress is being made!!!
rover
P.S. does it really take 10 years to develop a drug and get it on the market??!!
Posted by deniseuk190466 on October 4, 2007, at 14:56:45
In reply to Re: The thing about this ketamine trial., posted by rovers95 on October 2, 2007, at 11:17:45
Hi,
Thanks for the link. So it does seem that way, they only have given the trial participants ketamine once. God that must be awful if you did get a response. Having something that makes you not depressed for 7 days and then for it to be taken away completely. Why does it take 10 years to develop a drug before it hits the market anyway?
I did a search on CP-101,606 which was mentioned in the report and couldn't really find much, so they have tried it out on 20 patients already and it had remarkable affects so why can't they hurry up with the studies and get it out on the market quick?
Denise
Posted by rovers95 on October 5, 2007, at 7:51:08
In reply to To Rover, posted by deniseuk190466 on October 4, 2007, at 14:56:45
Ditto.........i want to try it now!!!!
rover
This is the end of the thread.
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