Shown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Gary Engel on October 2, 2007, at 16:24:18
In another scenario, the patient is intolerant of the SSRI and a "paradoxic" reaction develops that may include the "jitteriness syndrome." The paradoxic reaction consists of marked sensitivity to the SSRI with development of increased anxiety, jitteriness, or a feeling of "jumping out of one's skin," worsening depression, and irritability. The paradoxic reaction may be responsible for the emergence of suicidal ideation in the context of SSRI administration.5,16
The occurrence of a paradoxic reaction to an SSRI does not bode well for future SSRI treatments, and we include it as a possible side effect when communicating information before we begin treatment with an SSRI. This form of treatment resistance is best managed by starting with an atypical antipsychotic or an anticonvulsant, such as gabapentin or topiramate (although neither is particularly effective in bipolar disorder), or lamotrigine. An SSRI can be added later with reduced likelihood of a paradoxic reaction.
The above excerpt came from an article I found online from http://www.psychiatrictimes.com/topic/Anxiety/showArticle.jhtml?articleID=193500624&pgno=2&topic=Anxiety
Should I ask my pdoc to give me Lamictal and then try the SSRI as the Paradoix reaction is totally me?
Posted by linkadge on October 2, 2007, at 21:25:51
In reply to Having Paradoxic Rxn to SSRI's.....? re: Lamictal, posted by Gary Engel on October 2, 2007, at 16:24:18
Well, at least they're getting close to reality. They are at least admitting to the possability that the SSRIs may actually be, as some patients claim, actually causing more anxiety.
I cannot agree with their conclusion though.
"is best managed by starting with an atypical antipsychotic or an anticonvulsant, such as gabapentin or topiramate (although neither is particularly effective in bipolar disorder), or lamotrigine. An SSRI can be added later with reduced likelihood of a paradoxic reaction."
This is kind of B.S. It's just a responce to the fact that they don't have anything else to try. (Ie We have red pills and we have blue pills, and if red pills don't work then blue pills will)
Mind you, there are some people who respond well to these drugs, I just think there is this large, "gap" in treatments available, that some psychiatrists don't want to admit to.
Linkadge
Posted by Phillipa on October 2, 2007, at 22:39:20
In reply to Re: Having Paradoxic Rxn to SSRI's.....? re: Lamictal, posted by linkadge on October 2, 2007, at 21:25:51
Link I agree. Phillipa
Posted by bleauberry on October 4, 2007, at 16:09:22
In reply to Having Paradoxic Rxn to SSRI's.....? re: Lamictal, posted by Gary Engel on October 2, 2007, at 16:24:18
To me, paradoxical reation means one of two things:
1) The drug is messing up the chemical imbalance in the wrong direction. Targeting the wrong thing.
2) Toxicity. Lead, mercury, copper, silver fillings.Whenever a patient walks into my doc's office with a history of paradoxical reactions or super sensitive reactions, his first mini-diagnose that is confirmed or refuted with further examination and possibly lab tests is toxic exposure buildup. In more cases than not, the paradoxical patients do turn out to be toxic and it is the first time they ever heard of it or suspected it.
An unknown hidden infection can also cause a paradoxical reaction. Such as candida overgrowth or a hidden food intolerance that you are not aware of. Probably something you really like and you eat it all the time and don't suspect it. Gluten in wheat, barley and oats is turning out be a much bigger offender than anyone suspected. Some estimates are that 15% to 30% of the population are intolerant of gluten and most of them do not know it. Any kind of infection or intolerance reaction will spill chemicals into the blood that really mess with brain chemistry and glands.
Anyway, just some things to ponder.
Posted by Phillipa on October 4, 2007, at 19:41:21
In reply to Re: Having Paradoxic Rxn to SSRI's.....? re: Lamictal, posted by bleauberry on October 4, 2007, at 16:09:22
Don't eosinophils or basophils indicate allergic reaction in a CBC? Phillipa
Posted by bleauberry on October 5, 2007, at 14:07:41
In reply to Re: Having Paradoxic Rxn to SSRI's.....? re: Lamictal » bleauberry, posted by Phillipa on October 4, 2007, at 19:41:21
> Don't eosinophils or basophils indicate allergic reaction in a CBC? Phillipa
My doc told me this week that eosinophils is an indication of allergic response. Mine was high. Don't know what I'm allergic to. A food? Mold? Plastic? Chemical? I do know that allergies, intolerances, and sensitivities go hand in hand with mercury toxicity from amalgams, so this is just yet one more of many confirmations.
Sorry, I don't know about the other word you mentioned.
Posted by Phillipa on October 5, 2007, at 20:12:52
In reply to Re: Having Paradoxic Rxn to SSRI's.....? re: Lamictal, posted by bleauberry on October 5, 2007, at 14:07:41
Blueberry always get them confused. Not sure what the other is indicitive but mine are all normal so I guess I have no allergies? Phillipa
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