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Dr. Bob is Robert Hsiung, MD,
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Posted by chiron on August 3, 2007, at 23:13:24
this research study was specifically about Celexa, but I thought it was interesting that we are slowly making progress...
Antidepressant Effectiveness May Depend on Genes
http://health.msn.com/healthnews/articlepage.aspx?cp-documentid=100167279
RESULTS: In addition to the previously identified marker in the HTR2A gene, a new marker (rs1954787) in the GRIK4 gene, which codes for the kainic acid-type glutamate receptor KA1, was observed. The effect size of the GRIK4 marker alone was modest, but homozygote carriers of the treatment-response-associated marker alleles of both the GRIK4 and HTR2A genes were 23% less likely to experience nonresponse to treatment relative to participants who did not carry any of these marker alleles. CONCLUSIONS: The findings demonstrate that genetic variation in a kainic acid-type glutamate receptor is reproducibly associated with response to the antidepressant citalopram. This finding suggests that the glutamate system plays an important role in modulating response to selective serotonin reuptake inhibitors (SSRIs).
Posted by SadDoggie on August 4, 2007, at 3:18:44
In reply to Article - genes influence antidepressant response, posted by chiron on August 3, 2007, at 23:13:24
That's interesting and all but when it comes to genes news it means don't expect this to be of any use any time soon.
Posted by Phillipa on August 4, 2007, at 12:18:57
In reply to Re: Article - genes influence antidepressant response, posted by SadDoggie on August 4, 2007, at 3:18:44
Where does any of you acquire your knowledge of genes? Seriously? Love Phillipa
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