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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 11 to 35 of 45. Go back in thread:
Posted by Jedi on July 13, 2007, at 21:57:59
In reply to Re: Stablon is GOD in pill form!, posted by becksFLA on July 13, 2007, at 17:53:19
> in all my years on this board why haven't i seen this drug come up even once? i'm definitly going to at least ask my doctor about it. i dont think i've really even read much about SSRE's.
I got 2950 hits while searching www.dr-bob.org for tianeptine with Google. It has been discussed. Jedi
Posted by brooke484 on July 14, 2007, at 8:37:19
In reply to Re: How did you get it? » brooke484, posted by tendency on July 13, 2007, at 20:07:36
So is a doctor prescribing it for you or are you taking it yourself? Just curious.
Posted by zmg on July 16, 2007, at 19:00:59
In reply to Re: How did you get it? tendency, posted by brooke484 on July 14, 2007, at 8:37:19
tendency,
I'm really glad it's working so well for you. I didn't have such remarkable results, but on the flip I didn't have terrible side-effects (I had some agitation, but I ended up taking it concurrently with Valium and then stopped the Valium and it seemed fairly good with the anxiety).Servier created it as a replacement for Survector (amineptine) which was highly praised by some but banned in most countries due to concerns about abuse (which if you read about seem largely hyped). Its a class pretty much of it's own (SSRE) which might be part of the reason it hasn't been made available in a lot of countries.
http://en.wikipedia.org/wiki/SSRE
http://en.wikipedia.org/wiki/StablonI think it's a pretty interesting drug, but it didn't seem to help me a lot (obviously some people find it to be really helpful, which is wonderful).
I do believe technically to import it (which is perfectly legal) you should have a prescription which would be included in the package. It's manufactured in India (I'm not sure where else).
It's kind of picked up a cult following. Importation can be expensive depending on the source (which of understandably we can't discuss here) but it can be found priced reasonable.
Posted by linkadge on July 17, 2007, at 8:56:28
In reply to Re: How did you get it? tendency, posted by zmg on July 16, 2007, at 19:00:59
It would be interesting to ultimately see how serotonin transporter testing might ultimately influence responces to SSRI's verse SSRE's.
Do those with the SS varient of the serotonin transporter fair better with tianeptine than with SSRI's? Would tianeptine work better in individuals with the SS varient of the serotonin transporter, who do poorly on SSRI's in general.
While I don't see tianeptine coming to America, I hope some of these questions get partially answered.
Linkadge
Posted by tendency on July 17, 2007, at 9:43:22
In reply to Re: How did you get it? tendency, posted by linkadge on July 17, 2007, at 8:56:28
I agree..my testing with Tianeptine has led me to believe that ultimately the efficacy of ADs has not little to do with their direct manipulation of transmitters but some other downstream effect.
I say this, in part, because I always responded quite well to SSRIs - they knocked out my anxiety and greatly alleviated depression but had side effects that I couldnt tolerate.
So a drug that seemingly works the opposite of SSRIs left me doubting I'd receive any benefit, in fact, I was prepared to feel much worse.
However, some two weeks after starting treatment I'd say it's actually working better than SSRIs w/ no side effects.
Go figure.
Posted by linkadge on July 17, 2007, at 10:10:47
In reply to Re: How did you get it? tendency » linkadge, posted by tendency on July 17, 2007, at 9:43:22
Well the problem is that the SSRI's are really not all that selective.
All of the currently available SSRI's boost the activity of the powerful gabaergic neurosteroid alloprenanalone some 20 fold.
Allong these lines, it is possable that a patient receive benifit from one mechanism, and also have side effects from the other mechanism.
Although, it could be like you say, little to do with the puported mechanisms.
Linkadge
Posted by Sigismund on July 17, 2007, at 15:03:52
In reply to Re: How did you get it? tendency » linkadge, posted by tendency on July 17, 2007, at 9:43:22
Excellent. You've taken both tianeptine and SSRIs.
Can you compare them for us?
(I remember someone else here saying he found the effect of tianeptine softer and warmer.)
You might think the effects would be quite dissimilar.
Posted by elanor roosevelt on July 17, 2007, at 21:34:52
In reply to Tianeptine and SSRIs » tendency, posted by Sigismund on July 17, 2007, at 15:03:52
This is a very pro-sensual drug for me. I can't take it all the time bc it makes me a bit edgy but I take "as needed" and think it is fine.
Posted by confuzyq on July 18, 2007, at 0:53:40
In reply to Tianeptine: pro-sensual, posted by elanor roosevelt on July 17, 2007, at 21:34:52
Hi Eleanor (or anyone else with experience)! So this works ok for you taking only as often or infrequently as needed? Interesting since that would make the expense and hassle of obtaining from the U.S. more manageable. Thanks!
> This is a very pro-sensual drug for me. I can't take it all the time bc it makes me a bit edgy but I take "as needed" and think it is fine.
Posted by tendency on July 18, 2007, at 11:13:11
In reply to Tianeptine and SSRIs » tendency, posted by Sigismund on July 17, 2007, at 15:03:52
Here are my thoughts:
Tianeptine, so far, has been excellent at virtually eliminating by anxiety, apprehension, fear and excess worry. Almost every morning I (before stablon) would wake up with tightness in my chest, prickly fear throughout my body, feelings of worry circulating in my head and a general sinking and sense of foreboding sensation in the pit of my stomach. Within 30 minutes of my stablon dose these symptoms are probably 95% eliminated. Very impressive.
I've also found very potent anti-depressive qualities. Depression, for me, often manifests as deep feeling of grief and sadness (which are very physical in nature) coupled with a general tendency to view stimulus in a negative painful manner.
Tianeptine has greatly improved this. Here's a typical example of benefits I've noticed: Before tianeptine I would often be overcome by sadness and despair with the slightest outside event triggering an episode. On stablon, my 'resistance' to stimulus triggering an event is dramatically improved. Things that normally would really bother me barely register, and, when they do, my reactions are MUCH less strong and last for a much shorter duration. The best way I can describe this is perhaps to say that stablon appears to be an emotional stabilizer.
However, what's great about stablon, compared to SSRIs, is that I havent noticed emotional blunting. For me, SSRIs worked quite well for the above symptoms but they would leave me somewhat sedated, cognitively impaired and, worse still, deadened to both the bad AND good in life. It felt like my ability to experience pleasure, joy, excitement, awe, etc. were reduced in equal measures as my reduction in feeling 'negative' emotions. Not good.
I've not noticed this with stablon. In fact, quite the opposite. I find myself much more 'in tune' with joy, happiness, awe, wonder, contentment etc. on stablon while at the same time enjoying a quite pronounced reduction in depressive symptoms as outlined above.
So, in that regard I would say stablon is certainly 'warmer' than SSRIs. One last note, I do need to take stablon 3 times/day as it does have a very short half life. It's quite noticeable when it wears off too..like clockwork about every 4 hours I'll feel the tightness returning to my chest and see my emotional equilibrium rapidly deteriorating and I'll realize it's time for my next dose.
-M
Posted by Sigismund on July 18, 2007, at 17:06:10
In reply to Tianeptine: pro-sensual, posted by elanor roosevelt on July 17, 2007, at 21:34:52
>This is a very pro-sensual drug for me. I can't take it all the time bc it makes me a bit edgy but I take "as needed" and think it is fine.
Yes, that's my experience too, except I take it all the time.
It worked straight away on me, more or less.
I also wonder if it has been helpful with depersonalisation?
Posted by Sigismund on July 18, 2007, at 17:11:16
In reply to Tianeptine vs. SSRIs » Sigismund, posted by tendency on July 18, 2007, at 11:13:11
>Depression, for me, often manifests as deep feeling of grief and sadness (which are very physical in nature) coupled with a general tendency to view stimulus in a negative painful manner.
Yes!
It got me out of the house, which was impressive.As I said above, I'm wondering if it has been helpful with depersonalisation.
I'm just reading "Feeling Unreal" which is very interesting.
Posted by Sigismund on July 18, 2007, at 17:18:37
In reply to Tianeptine: pro-sensual, posted by elanor roosevelt on July 17, 2007, at 21:34:52
Since one of the characteristics of depersonalisation is an overemphasis on the part of us that observes ourselves (and in particular our mental state and thoughts), any drug that helps us feel grounded by reconnecting with our (what am I supposed to say here?) bodies? meat? will be helpful.
Posted by Sigismund on July 18, 2007, at 17:21:05
In reply to Depersonalisation and sensuality, posted by Sigismund on July 18, 2007, at 17:18:37
corporeal frame?
Posted by brooke484 on July 18, 2007, at 18:52:57
In reply to Tianeptine vs. SSRIs » Sigismund, posted by tendency on July 18, 2007, at 11:13:11
I already asked this (maybe you missed the post), but can you tell me if a doctor is prescribing it for you or are you treating yourself? Thanks.
Posted by coral on July 18, 2007, at 19:48:25
In reply to Stablon is GOD in pill form!, posted by tendency on July 13, 2007, at 15:23:52
Has anyone taken Stablon and an SSRI, specifically Zoloft? Thanks!
Posted by Last Chance on July 18, 2007, at 22:10:54
In reply to Stablon is GOD in pill form!, posted by tendency on July 13, 2007, at 15:23:52
Have you been able to cut the tabs ok - use a pill cutter or ? thanx, Richard
Posted by tendency on July 18, 2007, at 22:33:57
In reply to Re: Stablon is GOD in pill form! » tendency, posted by Last Chance on July 18, 2007, at 22:10:54
Yes - I've had good luck cutting the tabs. I've found the best method to be a steady hand and sharp x-acto knife.
I started at 1/2 tab BID so no problems w/ cutting 'em.
Posted by tendency on July 18, 2007, at 22:35:01
In reply to question for tendency, posted by brooke484 on July 18, 2007, at 18:52:57
Yes - I perform all my med trials under the supervision and direction of a psychiatrist.
Posted by FredPotter on July 18, 2007, at 22:47:38
In reply to Re: Depersonalisation and sensuality, posted by Sigismund on July 18, 2007, at 17:21:05
Posted by Sigismund on July 19, 2007, at 3:02:58
In reply to Mortal coil? (nm), posted by FredPotter on July 18, 2007, at 22:47:38
Obviously we are mortal, but also we are the coil?
Posted by Sigismund on July 19, 2007, at 15:05:40
In reply to I never knew what that meant » FredPotter, posted by Sigismund on July 19, 2007, at 3:02:58
I only tried it the once, but it seemed pretty good.
Posted by brooke484 on July 21, 2007, at 20:13:24
In reply to Re: question for tendency » brooke484, posted by tendency on July 18, 2007, at 22:35:01
That's great. I'm going to print out some info about this drug for my doctor. Maybe he will consider it. I'm running out of options!
brooke
Posted by cruise on July 23, 2007, at 0:04:29
In reply to Thanks!, posted by brooke484 on July 21, 2007, at 20:13:24
Hi, I started on Stablon four weeks ago switching from Celexa. I have read nothing but good things about it other than one poster who seems to be having the same reaction I am, which is basically still feeling depressed.
The thing in common we have is we are both also taking Klonopin and I'm wondering if it affects the effectiveness of Stablon.
I've already begun to taper the Klonopin as I really want to give it a good try.
Posted by Sigismund on July 23, 2007, at 3:03:25
In reply to Stablon and Clonazepam, posted by cruise on July 23, 2007, at 0:04:29
I can think of a few people who didn't like it because it made them feel weird, and others who said it had no effect on their depression.
But depression is one of those words, I have no idea what it means, not really.
Perhaps there has been a consensus that Stablon is mildly pro-social?If I had switched from Celexa to Stablon, one thing I'd be thinking is that these drugs apparently work in opposite ways, and how long is it going to take for my brain to get used to that??
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