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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by Ines on March 14, 2007, at 17:42:48
Hello everyone,
I'm just facing a change in meds- reboxetine getting me worse rather than better. I really want something to work by yesterday, getting impatient about medication roller coaster... Anyway, I'm in the UK and the only MAOI my GP will agree to prescribe is moclobemide, although in his opinion it's not a very effective drug. I have chronic atypical depression, some anxiety and some obsessive tendencies (but depression definitely overrides everything else). Does anyone have similar symptoms and positive or negative experiences with moclobemide?
Thanks! Ines
Posted by alienatari on March 14, 2007, at 18:58:15
In reply to moclobemide for atypical depression, posted by Ines on March 14, 2007, at 17:42:48
I have "severe ocd" apparently and anyway moclobemide mate it worse and did nothing for my depression. Actually I think it made me worse but thats just my experience.
If you have OCD why dont you try Clomipramine?
Take care
Chris
Posted by Phillipa on March 14, 2007, at 21:52:30
In reply to Re: moclobemide for atypical depression, posted by alienatari on March 14, 2007, at 18:58:15
There's a poster from another country as well that will post probably on this tomorrow. Don't think good results but not for me to say. Love Phillipa
Posted by Quintal on March 14, 2007, at 22:22:47
In reply to moclobemide for atypical depression, posted by Ines on March 14, 2007, at 17:42:48
I took moclobemide for three months back in 2003 and it was useless. It had absolutely no effect at all apart from causing insomnia in the first few weeks. I've heard from others who have used it though and it made their depression much worse with agitation and suicidal thoughts to boot. I've yet to hear anyone claim a good response to it after years of researching. I wouldn't recommend it.
GPs can't prescribe the non-selective, irreversible MAOIs on their license in the UK - you need to see a psychiatrist for that. As another poster has suggested, clomipramine is another med your GP should be willing to prescribe that could be more effective for those problems you are having.
Q
Posted by Meri-Tuuli on March 15, 2007, at 2:35:00
In reply to Re: moclobemide for atypical depression » Ines, posted by Quintal on March 14, 2007, at 22:22:47
Hey Ines!
I took moc for all of about a week a year ago now. I started on a really small dose, as I'm quite med sensitive. Anyway, well it was obviously too short a time period to tell anything, but it definately gave me more energy and motivation. I can see how agitation might be an issue through, but the extra energy was very welcome for me! I was on holiday in Ireland at the time, and I seem to remember really really enjoying the holiday, which is relatively rare for me! It also made me feel abit faint and light headed at times, which apparently are very common side effects. I had to stop because I got a slight rash on the back of my hands, and being the hypochrondiriac that I am, completely stopped the moc.
Oh well.
Have you thought about Zyban/wellbutrin/bupropion?
That give me extra energy and stopped carb cravings. However, it also made my anxiety worse, and I again got a funny rash on it, so I stopped.
Here's a good drug chart complied by our very own SLS which is a good base: (my apologies if you're already come across it before)
http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html
Kind regards
Meri
Posted by Meri-Tuuli on March 15, 2007, at 2:37:24
In reply to Re: moclobemide for atypical depression, posted by Meri-Tuuli on March 15, 2007, at 2:35:00
Or what about provigil?
I've always been interested in that.
What do other babblers think about provigil (or one of those types) in the UK?
Kind regards
Meri
Posted by Ines on March 15, 2007, at 9:11:22
In reply to Re: moclobemide for atypical depression, posted by Meri-Tuuli on March 15, 2007, at 2:37:24
Hello everyone,
Thanks for posting. It doesn't sound like Moclobemide has many fans... The GP won't change my meds now until I see a psychiatrist, so I'll just have to stick to reboxetine and wait and wait... I'm going to sit down and work out my budget to see if I can afford to go see a private psychiatrist, I'm not sure I can wait for weeks and weeks in this situation... Anxiety through the roof with reboxetine, this weird kind of anxiety that feels like there's some major danger I need to run from but I don't know what it is :-(
Posted by Meri-Tuuli on March 15, 2007, at 12:26:02
In reply to Re: moclobemide for atypical depression, posted by Ines on March 15, 2007, at 9:11:22
Well just quit the rebox! I have also tried reboxetine and was on it for some time too. The good news is that withdrawal on rebox is a snip compared to the SSRIs. So........
Kind regards
Meri
Did you ever try the zyban thing?
Posted by Ines on March 15, 2007, at 13:15:24
In reply to Re: moclobemide for atypical depression, posted by Meri-Tuuli on March 15, 2007, at 12:26:02
Hey Meri,
I think I may well do that (quit the rebox that is). I'm just a bit scared of taking nothing for weeks... I was pretty bad before I started the reboxetine- crying all the time, had to take time off work. But then I'm worse now, only in a different way- but at least I manage to work. I'm still a bit stunned after my appointment- I was thinking the GP would get me to try something else whilst waiting for referral, but I made the mistake of actually mentioning to him my problem with constant streams of thoughts, which seemed to make him scared of treating me at all! Can't imagine how he would have reacted if I told him the content of some of those thoughts! :-)
I was keen on trying Wellbutrin before I got prescribed reboxetine, but feel put off now since they both act mainly on noradrenaline, and that's clearly not doing me much good. But as it is I'll now just have to wait until I can get a referral to a psychiatrist- and in the meantime I can eirther keep taking the reboxetine or go cold turkey...or I'm thinking it might be a good time to give Rhodiola a go.
Hope you're doing OK.
Ines
Posted by Declan on March 15, 2007, at 20:38:05
In reply to Re: moclobemide for atypical depression » Ines, posted by Quintal on March 14, 2007, at 22:22:47
>GPs can't prescribe the non-selective, irreversible MAOIs on their license in the UK - you need to see a psychiatrist for that<
Fortunately it's not like that in Australia.
A GP prescribed me Parnate.Moclobemide certainly did stuff to me, but I never got beyond 1/4 of the normal starting dose.
I can see it could be agitating.
Posted by Meri-Tuuli on March 16, 2007, at 2:07:45
In reply to Re: moclobemide for atypical depression » Meri-Tuuli, posted by Ines on March 15, 2007, at 13:15:24
Hey!
Wellbutrin mainly acts more on dopamine to be honest. But anyway you'll have to discuss that with your pdoc.
As for the Rhodiola, its pretty great, you have all the info you need? Be prepared that your pdoc will probably not have heard about Rhodiola - mine certainly hadn't. In fact, my herbalist hadn't even heard of it which was quite surprising. Anyway. Its good - it definately brightened my mood, and gave me energy although it did aggrevate my anxiety somewhat. But of course, your experiences did vary.
Let us know how it goes!
Did you ever try SJW? Or you might actually want to try tyrosine. I loved tyrosine, although I don't really take it. I should probably take some now on bad days.
Kind regards
Meri
Posted by FredPotter on March 17, 2007, at 19:27:57
In reply to moclobemide for atypical depression, posted by Ines on March 14, 2007, at 17:42:48
I found Moclobemide worked in 2-3 days but then stopped and may even have caused me to feel worse. It seems to fall off its horse as soon as a bit of Marmite or a broad bean pod floats by
I had this idea. What would happen if you took Moclobemide and DID stick to the no-tyramine diet? If things knock it off its perch, and you don't eat those things, perhaps it won't fall off its perch.
Crazy?
Probably Fred
Posted by psychobot5000 on March 21, 2007, at 12:55:43
In reply to moclobemide for atypical depression, posted by Ines on March 14, 2007, at 17:42:48
the only MAOI my GP will agree to prescribe is moclobemide, although in his opinion it's not a very effective drug. I have chronic atypical depression, some anxiety and some obsessive tendencies (but depression definitely overrides everything else). Does anyone have similar symptoms and positive or negative experiences with moclobemide?
> Thanks! InesI have similar symptoms--chronic atypical depression, with some anxiety and obsessive tendencies. I tried moclobemide about two years ago, and found that it was not very effective, in comparison to other meds, though it had few side-effects for me. I did not, overall, find it useful.
For what it's worth, I think that some MAOi experts would recommend Phenelzine/nardil for anxious, obsessive, atypical depression. Clomipramine seems a very good idea, too, though--I had both those drugs recommended to me on the basis of similar symptoms.
P-bot
Posted by Helspeb on March 26, 2007, at 5:30:41
In reply to moclobemide for atypical depression, posted by Ines on March 14, 2007, at 17:42:48
> Hello everyone,
> I'm just facing a change in meds- reboxetine getting me worse rather than better. I really want something to work by yesterday, getting impatient about medication roller coaster... Anyway, I'm in the UK and the only MAOI my GP will agree to prescribe is moclobemide, although in his opinion it's not a very effective drug. I have chronic atypical depression, some anxiety and some obsessive tendencies (but depression definitely overrides everything else). Does anyone have similar symptoms and positive or negative experiences with moclobemide?
> Thanks! InesHi Everyone
Sorry for late response to your post, only just come accross the site. I have been taking Moclobemide for 5 months having tried SSRI's resulting in nasty side effects. I have depression, chronic panic attacks and am agoraphobic. Since taking the medication I have returned to work, and a near normal life, this drug has certainly helped with my symptoms, however one side effect weight gain. Was wondering if anyone else had the same side effect?
Posted by Ines on March 26, 2007, at 11:58:47
In reply to Re: moclobemide for atypical depression » Ines, posted by psychobot5000 on March 21, 2007, at 12:55:43
Hi P-bot,
Have either of those worked for you? I would like to try phenelzine but GP refuses to prescribe a MAOI... Ines
Posted by Ines on March 26, 2007, at 12:02:00
In reply to Re: moclobemide for atypical depression » Ines, posted by Helspeb on March 26, 2007, at 5:30:41
Hi Helspeb,
I'm really glad Moclobemide has worked for you. Also hopeful to hear one person that has had a good result from it! If you really want to find out about moclobemide and weight experiences it might be worth starting a thread on that, as this one is a bit old and may not be picked up by many people...
Ines
Posted by FredPotter on March 26, 2007, at 18:16:25
In reply to Re: moclobemide for atypical depression » Ines, posted by Helspeb on March 26, 2007, at 5:30:41
No I had no side effects - OR effects!
Posted by psychobot5000 on March 28, 2007, at 11:20:59
In reply to Re: moclobemide for atypical depression » psychobot5000, posted by Ines on March 26, 2007, at 11:58:47
> Hi P-bot,
> Have either of those worked for you? I would like to try phenelzine but GP refuses to prescribe a MAOI... InesWell, no, neither of these have worked for me--however (!), I have not really had an adequate trial with either of them. For what it's worth, I am getting some very significant relief with tranylcypromine--but I think that's mostly just luck of the draw, that it -seems- to work better. In any case, if your doc won't prescribe MAOis, I suppose it's not that helpful....
I only -very- briefly tried clomipramine, and balked because of SSRI-like symptoms (initial anxiety and mild akathisia). From what I was told, if you go up in dosage very slowly, it's supposed to be a fairly tolerable (and powerful, for compulsive symptoms and depression) drug, but you need patience. Sorry I can't give you more information, but after I got the recommendation for phenelzine or clomip, which seemed based on very sensible arguments, I decided that because of my own personal record of side-effects from phenelzine and from tricyclics, I'd be better off trying something else first. Thus, the tranylcypromine.
Best,
P-bot
This is the end of the thread.
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