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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by iforgotmypassword on February 18, 2007, at 4:41:51
apparently in canada it is legal to get outside drugs via some paperwork (i.e. the "Special Access Program"?) to be purchased directly from the manufacturer.
i also saw a *.ca site selling solian (amisulpride.) mind you they may not have been low-dose compatible (i.e. 200mg and i do not know if they were designed to be divisible properly) and expensive.
trying to piece together how i do this with only a sliver of a functional brain.
i am also worried about its antihistamine activity. does it actually not have any?
Posted by munificentexegete on February 18, 2007, at 7:06:13
In reply to get solian (amisulpride) in canada? H1 activity?, posted by iforgotmypassword on February 18, 2007, at 4:41:51
> apparently in canada it is legal to get outside drugs via some paperwork (i.e. the "Special Access Program"?) to be purchased directly from the manufacturer.
>
> i also saw a *.ca site selling solian (amisulpride.) mind you they may not have been low-dose compatible (i.e. 200mg and i do not know if they were designed to be divisible properly) and expensive.
>
> trying to piece together how i do this with only a sliver of a functional brain.
>
> i am also worried about its antihistamine activity. does it actually not have any?that drug is designed to shut down your dopamine receptors, especially with doses >50mg... that means either you want to block your brain from working properly, or you have had tests done and you have found that you have an overactive dopaminergic system in which case it could stablise your brain chemistry.
Posted by linkadge on February 18, 2007, at 8:25:35
In reply to Re: get solian (amisulpride) in canada? H1 activity?, posted by munificentexegete on February 18, 2007, at 7:06:13
Amisulpride is a different antipsychotic in that it blocks inhibitory presynaptic dopamine autoceptors with higher potency than post synaptic receptors.
It needs no dopamine test, and no acurate dopamine tests exist anyway.
Linkadge
Posted by Phillipa on February 18, 2007, at 10:44:32
In reply to Re: get solian (amisulpride) in canada? H1 activity?, posted by linkadge on February 18, 2007, at 8:25:35
Didn't know it was an antipsychoitic. Well that' why I'm here to learn. Love Phillipa
Posted by munificentexegete on February 18, 2007, at 15:33:30
In reply to Re: get solian (amisulpride) in canada? H1 activity?, posted by linkadge on February 18, 2007, at 8:25:35
> Amisulpride is a different antipsychotic in that it blocks inhibitory presynaptic dopamine autoceptors with higher potency than post synaptic receptors.
hiya link, but what is the effect of amisulpride? is it fair to say that in a healthy person, it binds with the D2 receptors above 50mg, effectively stopping a brain from working properly?
> It needs no dopamine test, and no acurate dopamine tests exist anyway.if your dopamine system was overactive, could an AP potientally help such a patient?
Posted by linkadge on February 18, 2007, at 16:44:50
In reply to Re: get solian (amisulpride) in canada? H1 activity? » linkadge, posted by munificentexegete on February 18, 2007, at 15:33:30
>hiya link, but what is the effect of >amisulpride? is it fair to say that in a healthy >person, it binds with the D2 receptors above >50mg, effectively stopping a brain from working >properly?
It is difficult to say what the net effect of
amisulpride is on post-synaptic dopaminerigic neurotransmission. Because it has more potent activity at presynaptic receptors, it will enahance dopamine release. Yes, it will partially block the activity of that released dopamine, but the net effect on the post synaptic repceptor is unknown.> It needs no dopamine test, and no acurate dopamine tests exist anyway.
>if your dopamine system was overactive, could an >AP potientally help such a patient?
If an overactive dopamine system was at the heart of the problem, then an antipsychotic could provide symptomatic improvement. It would not really lower overall dopaminergic function, just the function of dopamine at certain receptors.
Linkadge
Posted by Quintal on February 18, 2007, at 22:21:22
In reply to get solian (amisulpride) in canada? H1 activity?, posted by iforgotmypassword on February 18, 2007, at 4:41:51
>i also saw a *.ca site selling solian (amisulpride.) mind you they may not have been low-dose compatible (i.e. 200mg and i do not know if they were designed to be divisible properly) and expensive.
It should be easy to divide them into quarters with a tablet cutter you can by from your local pharmacy.
>i am also worried about its antihistamine activity. does it actually not have any?
At low doses it has little, if any H1 blockade - never noticed it anyway.
Q
Posted by michael on February 20, 2007, at 11:17:15
In reply to Re: get solian (amisulpride) in canada? H1 activity?, posted by Quintal on February 18, 2007, at 22:21:22
> >i also saw a *.ca site selling solian (amisulpride.) mind you they may not have been low-dose compatible (i.e. 200mg and i do not know if they were designed to be divisible properly) and expensive.
>
> It should be easy to divide them into quarters with a tablet cutter you can by from your local pharmacy.
>
> >i am also worried about its antihistamine activity. does it actually not have any?
>
> At low doses it has little, if any H1 blockade - never noticed it anyway.
>
> Q
Just for the record, sulpiride, which is similar to amisulpiride, is available in Canada - or perhaps I should say that I purchased it from a Canadian internet pharmacy...It's not amisulpride, but as I said, it is similar. Fwiw, I prefer sulpiride - though it seems that amisulpride has tended to get better reviews/been more popular here at PB - at least from what I've read in the past.
michael
Posted by Quintal on February 20, 2007, at 12:34:30
In reply to Re: get solian (amisulpride) in canada? H1 activity?, posted by michael on February 20, 2007, at 11:17:15
May I ask why you prefer sulpiride michael? I've never taken it myself but could probably get it from my GP if I ask nicely. What are the differences?
Q
Posted by michael on February 20, 2007, at 21:06:10
In reply to Re: get solian (amisulpride) in canada? H1 activity?, posted by Quintal on February 20, 2007, at 12:34:30
> May I ask why you prefer sulpiride michael? I've never taken it myself but could probably get it from my GP if I ask nicely. What are the differences?
>
> Q
They're supposed to be quite similar, I think. I've tried each of them a couple of different times over the years.For me, 50 mg amisulpride tended to make me sleepy. I tried splitting the tablets in halfs, or quarters, but I never seemed to find a dose that was helpful.
The sulpiride's affect was subtle, but seemed to brighten my mood a little. As I said, it was subtle, but definitely noticeable (sp?) & worthwhile.
Of course, ymmv applies...
Ironically, I had expected the opposite, (that ami would work better) since amisulpride was specifically approved (in Italy at least) for dysthymia, which is my dx.
If you can get the sulpiride easier, it might be worth trying first. I experienced no side effects on the sulpiride (and only sedation on amisulpride). Sulpiride may also be cheaper (since it's older & possibly locally available?)... And personally, I also found that it kicked in, in a few days (though amisulpride also has a reputation for working quickly). I took 150 mg Sulpiride (50 mg 3x daily) - never really tried lower doses, even though I always intended to do so...
My current pdoc is uncomfortable dealing w/either, since they're not fda approved. So I've just begun a trial of abilify, in addition to 300 mg wellbutrin xl. I'm starting with only 2.5 mg of abilify, because the wellbutrin interferes w/the metabolism of the abilify, which makes it work like a larger dose than 2.5 mg (at least I think that's how it works). Abilify's mechanism is different than the other 2, but it too works on the dopamine system.
Hope you can make some sense of my ramblings...
michael
This is the end of the thread.
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