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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Klavot on February 17, 2007, at 11:34:59
Hiall
Ifantipsychoticslowerdopaminergicactivitythenwhydotheyhaveapro-motivationaleffect?
Klavot
Posted by Phillipa on February 17, 2007, at 11:49:13
In reply to Antipsychotics+motivation, posted by Klavot on February 17, 2007, at 11:34:59
Klavot no spaces you might want to retype hard to read. Love Phillipa
Posted by Klavot on February 17, 2007, at 13:48:19
In reply to Re: Antipsychotics+motivation » Klavot, posted by Phillipa on February 17, 2007, at 11:49:13
> Klavot no spaces you might want to retype hard to read. Love Phillipa
Sorry! I must have had the space bar option turned of :) There are those who will never accept our philosophy, and that's OK. Now urban legend has it that Otto Krauss was a German engineer at the Ford Motor Company in the 1930's, and when doing quality control, he would approve a batch of cars by signing his initials "OK" - hence the term OK.
What I meant to say was (... drum roll ...)
Hi all
If antipsychotics lower dopaminergic activity then why do they have a pro-motivational effect?
Klavot
Posted by Quintal on February 17, 2007, at 16:48:02
In reply to Re: Antipsychotics+motivation, posted by Klavot on February 17, 2007, at 13:48:19
>If antipsychotics lower dopaminergic activity then why do they have a pro-motivational effect?
You're the first person I've heard to say antipsychotics have a pro-motivational effect. They're notoriously anti-motivational and that's partly why they're used in prisons and psychiatric hospitals to subdue violent and disruptive individuals, not just because of their antipsychotic effect. I suppose some people who have *severe* depression or paralyzing anxiety might find their ability act on their desires improved after those obstacles are removed or reduced somewhat, but it would be a little misleading to extrapolate that into saying antipsychotics are pro-motivational.
Some newer antipsychotic drugs such as Abilify might help motivation, but Abilify has a different effect at D2 receptors being a partial agonist rather than an antagonist.
Q
Posted by Klavot on February 17, 2007, at 17:33:05
In reply to Re: Antipsychotics+motivation » Klavot, posted by Quintal on February 17, 2007, at 16:48:02
I may well be wrong; I'm certainly no expert on neuroleptics. I was under the impression that low dose APs have a pro-motivational effect, but apparently not. Yes, that makes sense.
Mmm... Just forget I said anything.
Thanks anyway.
Klavot
> >If antipsychotics lower dopaminergic activity then why do they have a pro-motivational effect?
>
> You're the first person I've heard to say antipsychotics have a pro-motivational effect. They're notoriously anti-motivational and that's partly why they're used in prisons and psychiatric hospitals to subdue violent and disruptive individuals, not just because of their antipsychotic effect. I suppose some people who have *severe* depression or paralyzing anxiety might find their ability act on their desires improved after those obstacles are removed or reduced somewhat, but it would be a little misleading to extrapolate that into saying antipsychotics are pro-motivational.
>
> Some newer antipsychotic drugs such as Abilify might help motivation, but Abilify has a different effect at D2 receptors being a partial agonist rather than an antagonist.
>
> Q
Posted by Quintal on February 17, 2007, at 17:57:04
In reply to Re: Antipsychotics+motivation, posted by Klavot on February 17, 2007, at 17:33:05
Were you referring to Solian (amisulpride) perchance? Amisulpride enhances dopaminergic transmission at doses of 50mg and below by blocking presynaptic autoreceptors (which are a feedback mechanism for controlling dopamine production and release into the synapse). This results in higher dopamine levels in the synapse and hence the pro-motivational effects.
Amisulpride and sulpiride are unique in doing this as far as I'm aware.
Q
Posted by med_empowered on February 19, 2007, at 3:15:30
In reply to Re: Antipsychotics+motivation » Klavot, posted by Quintal on February 17, 2007, at 17:57:04
I seem to recall reading about mini-doses of Haldol (like, 0.5mgs or something like that) having the effect of speeding up reaction times.
Anyway, in general, antipsychotics are notorious for slowing people down, causing dullness and general drug-induced apathy. The newer ones really aren't that much better--people still complain left and right about apathy and numbness--but sometimes with other meds (like the prozac/zyprexa mix) there are pro-motivational results so..its all kind of complicated. In general, blocking dopamine is going to cause slowness.
Posted by michael on February 20, 2007, at 10:50:15
In reply to Re: Antipsychotics+motivation » Klavot, posted by Quintal on February 17, 2007, at 17:57:04
> Were you referring to Solian (amisulpride) perchance? Amisulpride enhances dopaminergic transmission at doses of 50mg and below by blocking presynaptic autoreceptors (which are a feedback mechanism for controlling dopamine production and release into the synapse). This results in higher dopamine levels in the synapse and hence the pro-motivational effects.
>
> Amisulpride and sulpiride are unique in doing this as far as I'm aware.
>
> Q
Just writing to concur re: amisulpride & sulpride...At low doseages (I believe as mentioned above, amisulpride @ 50 mg and below, and sulpiride @ 50-150 mg) they're used as antidepressants.
I know that at least in Italy, amisulpride was approved by their equivalent of the FDA explicitly for dysthymia (which is a type of depression)
michael
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