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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by iforgotmypassword on January 24, 2007, at 21:09:50
Mechanism of action of galantamine on N-methyl-D-aspartate receptors in rat cortical neurons.
"Potentiation of the activity of NMDA receptors is deemed partially responsible for the improvement of cognition, learning, and memory in Alzheimer's patients."
huh? i read that it did something like this somewhere else too. how is this a good thing?
Posted by Phillipa on January 24, 2007, at 22:10:48
In reply to Mechanism of action of galantamine on NMDA recepto, posted by iforgotmypassword on January 24, 2007, at 21:09:50
Can you explain in simplier terms? Thanks Phillipa
Posted by rovers95 on January 25, 2007, at 2:39:57
In reply to Mechanism of action of galantamine on NMDA recepto, posted by iforgotmypassword on January 24, 2007, at 21:09:50
> Mechanism of action of galantamine on N-methyl-D-aspartate receptors in rat cortical neurons.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15121761&query_hl=8&itool=pubmed_DocSum
>
> "Potentiation of the activity of NMDA receptors is deemed partially responsible for the improvement of cognition, learning, and memory in Alzheimer's patients."
>
> huh? i read that it did something like this somewhere else too. how is this a good thing?By antagonising the NMDA receptor it blocks the action of glutamate which is the excitory transmitter and is also neurotoxic (therefore galantamine wil increase the effectiveness of GABA - the calming newurotransmitter, and reduce brain cell death.)
Having not studied galantamine (but having used memantine) i guess the reason this drug does not have a potent AD effect in humans is due to its lower binding strength to the NMDA receptor (than Ketamine or Magneium.)
mark
Posted by iforgotmypassword on January 25, 2007, at 5:52:14
In reply to Re: Mechanism of action of galantamine on NMDA rec, posted by rovers95 on January 25, 2007, at 2:39:57
Posted by iforgotmypassword on January 25, 2007, at 20:15:53
In reply to Re: Mechanism of action of galantamine on NMDA recepto » iforgotmypassword, posted by Phillipa on January 24, 2007, at 22:10:48
This is the end of the thread.
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