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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Maria3667 on January 20, 2007, at 11:32:54
Hi Folks!
Tianeptine is great for curbing my depression..... but it gives me the jitters so much I could be ringing Santa's bell for the rest of my life.
To counteract the anxiety my psy has given me some Ativan. But I'm weary of this because of the danger of dependance etc. So I'd rather try adding the anxiolitic Buspar (Buspirone).
Any thoughts, will this do the trick?
Kill off my libido?
Turn me into a big fat wobbling pudding? (yes x'mas on the mind)?Any ideas/thoughs/scientific explanations welcome!
Cheers,
Maria
Posted by Declan on January 20, 2007, at 11:32:55
In reply to TIANEPTINE and Buspar - any sense?, posted by Maria3667 on December 11, 2006, at 12:02:10
Can you find a dose of tianeptine that will help your depression but not give you the jitters?
Could a lower dose do that for you?
Posted by Maria3667 on January 20, 2007, at 11:32:55
In reply to Re: TIANEPTINE and Buspar - any sense? » Maria3667, posted by Declan on December 11, 2006, at 15:12:09
Hi Declan,
Yes, I went down to 2 doses of Tianeptine per day instead of 3. The jitters were still there and the med was losing it's AD-effect.
So now I've upped it again to 3 per day and just recently (since Saturday) added the Buspar (2x 10 mgs). So far it's calming me down and making me sleep a heap better.
I've only recently discovered that Tianeptine has an agonistic effect on the dopamine system. This explains the increase in anxiety for me. I had the same with Bupropion (Wellbutrin). If I would have known this before hand, I'm not sure I would have started the Tia. However, it's depression quenching properties are so marvellous I won't give it up without a fight first.
What I'm however mostly worried about is what the effect of Tia and Buspar will have together. Cancel each other out? Strengthen each other? Turn me into a fat pig? Strangulate my libido?
I hope someone can shed some light on this.
Thanks,
Maria
Posted by Vale on January 20, 2007, at 11:32:55
In reply to Re: TIANEPTINE and Buspar - any sense?, posted by Maria3667 on December 12, 2006, at 17:39:49
Sounds dicey . Potential for dyskinesia here.
( some cases associated with buspirone occured early on in treatment, and took years to resolve)
Tianeptine is itself anxiolitic, and it can also after many months of treatment cause minor facial nervous twitches, eyelids and mouth, temple.
One solution could be GHB. ( try and get it legally)
I've trashed all the A.D's . Aged single malt whisky (in moderation) does the trick!
Posted by Maria3667 on January 20, 2007, at 11:32:55
In reply to Re: TIANEPTINE and Buspar - any sense?, posted by Vale on December 13, 2006, at 13:40:24
Vale,
Thanks for the explanation and warning!
But it's still a little unclear to me why the combo Tianeptine & Buspar would possibly cause dyskinesia?
Would you please care to explain the mechanisms of action?
Cheers,
Maria> Sounds dicey . Potential for dyskinesia here.
> ( some cases associated with buspirone occured early on in treatment, and took years to resolve)
> Tianeptine is itself anxiolitic, and it can also after many months of treatment cause minor facial nervous twitches, eyelids and mouth, temple.
> One solution could be GHB. ( try and get it legally)
> I've trashed all the A.D's . Aged single malt whisky (in moderation) does the trick!
>
Posted by Maria3667 on January 20, 2007, at 11:32:55
In reply to Re: TIANEPTINE and Buspar - any sense?, posted by Maria3667 on December 13, 2006, at 13:59:45
Hi all,
Well, after trial & error I must conclude that tianeptine/buspar is a definate no-go area for me! The reason being that Tianeptine already causes constipation by itself and in combo with Buspar it makes is 10x worse. Last week I gained 2,7 kg - which really is a lot for just one week. Laxatives have little to no effect.
Also, the combination of Tianeptine & Buspar causes excruciating dry mouth and eyes (probably because Buspar works on the cholinergic system) and this is not tolerable with Sjogren's Syndrome. So I'll have to let it go.
Unfortunately, because whilst Tianeptine is good for depression it increases my anxiety level which Buspar seemed to quash.
So for now I'll just stick to Tianeptine and Ativan.
Maria
> Vale,
>
> Thanks for the explanation and warning!
>
> But it's still a little unclear to me why the combo Tianeptine & Buspar would possibly cause dyskinesia?
>
> Would you please care to explain the mechanisms of action?
>
> Cheers,
> Maria
>
> > Sounds dicey . Potential for dyskinesia here.
> > ( some cases associated with buspirone occured early on in treatment, and took years to resolve)
> > Tianeptine is itself anxiolitic, and it can also after many months of treatment cause minor facial nervous twitches, eyelids and mouth, temple.
> > One solution could be GHB. ( try and get it legally)
> > I've trashed all the A.D's . Aged single malt whisky (in moderation) does the trick!
> >
>
>
Posted by oldschool305 on January 20, 2007, at 11:32:55
In reply to TIANEPTINE and Buspar - any sense?, posted by Maria3667 on December 11, 2006, at 12:02:10
i haven't read the other uses responses yet, but I will tell you my experience with BUSPAR.... horrid... I only took HALF the pill prescribed to me and I was in bed for 3 days, I could not wake up.... barely made it to the bathroom and fell right back into bed....
Posted by linkadge on January 20, 2007, at 12:28:36
In reply to Re: TIANEPTINE and Buspar - any sense?, posted by oldschool305 on December 20, 2006, at 3:21:37
I think the combination would be worth a try.
The herb ginkgo biloba is a serotonin uptake acellerator as well as a 5-ht1a agonist. I can see some possably synergy.
As mentioned, buspar has a low possability of causing TD like effects. It has some antagonism at d2 receptors like antipsychotics.
The risk of TD with buspar is lower than with AP's. And probably lower if you keep it on the low end of dosing.
I'd say give it a try to find out.
Not everybody responds to buspar, but some people find it very helpful.
Linkadge
Posted by sukarno on January 22, 2007, at 9:28:41
In reply to Re: TIANEPTINE and Buspar - any sense?, posted by linkadge on January 20, 2007, at 12:28:36
Yeah, buspirone could cause TD...it is possible, although remote.
Tianeptine, on the other hand, wouldn't do that as it does give a mild boost to dopamine.
I've been on tianeptine for almost two years and in the beginning of treatment I did feel quite jittery as if I was having a chronic adrenaline rush (an unpleasant "rush"). That effect dissipated after about 1 week.
It happens if I increase the dose and that effect also lasts for a few days, then my body adjusts and I feel fine again. :-)
I think lorazepam (Ativan) will help you to feel calmer and is a good choice.
Good luck! :-)
Paul
Posted by elanor roosevelt on January 27, 2007, at 21:21:14
In reply to Re: TIANEPTINE and Buspar - any sense?, posted by linkadge on January 20, 2007, at 12:28:36
i gained almost 40 pounds on Buspar
from 120 to 160
blew out my knees from carrying the extra weight
This is the end of the thread.
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