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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 17 to 41 of 41. Go back in thread:
Posted by UgottaHaveHope on January 1, 2007, at 15:59:08
In reply to Re: Taking a poll - have you failed to quit Zyprex » blueberry1, posted by SLS on January 1, 2007, at 15:33:27
Im just wondering. Based on what Ive read in this post, it seems like the worst med ever. Anyone been helped by it?
Posted by med_empowered on January 1, 2007, at 17:50:23
In reply to Re: Are there any positives about Zyprexa?, posted by UgottaHaveHope on January 1, 2007, at 15:59:08
it isn't all bad. I could see using it as-needed for intense problems that can't be handled by non-drug interventions and/or benzos. Personally, very low doses of zyprexa briefly provided a much needed break. At 2.5 mgs or so, I had akathisia. So..I dont think its good long term, but I could see using it on a strictly as-needed basis.
Posted by kotsunega on January 1, 2007, at 18:01:04
In reply to Re: Are there any positives about Zyprexa?, posted by UgottaHaveHope on January 1, 2007, at 15:59:08
> Im just wondering. Based on what Ive read in this post, it seems like the worst med ever. Anyone been helped by it?
Oh yes, it was a life-saver for me. It was the only drug that completely solved my severe and decade-long mania and delusional (very destructive) thinking. It was the only drug that let me sleep at night. And THAT has been its seduction. Now that there are health concerns associated with this med; now that there are newer alternatives; it seems that escaping zyprexa's clutches in order to move on to those more favorable alternatives is extremely difficult, if not downright impossible. How convenient for zyprexa's manufacturer to have, unwittingly, reeled in a nice big captive audience.
Posted by laima on January 1, 2007, at 18:54:29
In reply to Re: Are there any positives about Zyprexa?, posted by kotsunega on January 1, 2007, at 18:01:04
It's really striking what a consensus users seem to have about zyprexa. I manged to get off it relatively painlessly compared to others, but I only used 2.5 and up to 5mg for about 6 weeks while coming off klonopin. Some of the warnings here on babble served as motivators- and I now feel better without it. But I gained at least, at least 10 pounds in 6 weeks despite not really doing anything different! (Except for starting adderall- which supposedly is such an appetite suppressant. But it's no match for zyprexa!) Plus I think it made me apathetic and lazy. It's as if it started bringing on the very symptoms which it's instructions claims it helps... I hope very much my metabolism isn't completely screwed up. Oh sure it made me feel better- for a handful of days until I started freaking out about how I couldn't quite zip my pants right anymore. Now, I am a vegetable and excercise sensation, but weight comes on easier than it comes off. I can't afford a new wardrobe, and I don't want one. I can't for the life of me figure out any good reason that doctors are so enamored with this med.
Posted by med_empowered on January 1, 2007, at 19:28:10
In reply to Re: about Zyprexa?, posted by laima on January 1, 2007, at 18:54:29
I dont know whats up w/ docs loving zyprexa, either. I think the way it was pushed helped. Here was a drug that (at first) seemed to be ideal: it stopped psychosis, mania, helped with depression, and since the risks of akathisia and tardive dyskinesia seemed so low, it could also be used for anxiety, OCD, agitation, sleep...on and on. If you look back to the 50s-70s, shrinks were in love with the old antipsychotics, too; they were used for ADD kids, drug withdrawal, depression, anxiety, bipolar, agitation, "senile agitation", so on and so forth. Back in the day there was even a book about it...I think it was called The tranquilizing of America, or something like that.
As a (former) psychiatric patient, I find it a little disturbing that shrinks fell in love with it. I mean, if the effects of a neuroleptic (apathy, docility, reduced emotion) produce what shrinks consider "success" in so many people, then what exactly do they think "mental health" looks like? A sedate, reasonably friendly but dull patient on a little bit of Thorazine? And why, knowing what neuroleptics do to creativity and emotions, do shrinks feel the need to spray them on everyone, for everything?
Its kind of scary.
Posted by Sebastian on January 1, 2007, at 19:30:13
In reply to Taking a poll - have you failed to quit Zyprexa?, posted by kotsunega on January 1, 2007, at 0:44:26
I've taken zyprexa for almost 10 years. i don't know how many times I tried to quit. I started with a dose of 10mg and stoped after 9 months for about 4 months. During that time I could not eat, sleep. I also went psychotic, ie, could not leave the house. So I went back on it for anouther 9 months, quit for anouther 4 months, same thing. That was the last time I quit for a while, about 4 years. The next time I tried to quit it was very difficult. I started by cutting the dose in half, I felt like I was going crazy for a few days, then it got easyer, but wished I had cut down slower. For the next month I felt fine but different, sort of less happy. Then I made a mistake and stoped taking the medicine all together. Days one and two were ok, then it was awfull, I could not eat, got very paranoid and started avoiding people, eating lunch and studying in my car and feeling like I was going to do something stupid like run and scream. Also did other stupid things like bust up laughing for no reason in class, every one just looked and avoided. Thoughts would race, I got extreamly woried about poeple for no reason, calling and calling and saying stupid stuff that made no sense. By the end of the week I was falling apart and littery finding it harder and harder to eat, literaly I could not get food down my throat. My parents told me to call the doctor, he instructed that I take 1.25mg zyprexa, within 15 min I could eat, and I started feeling calm again, something that didn't happen all week. Slowly I pleaded with my doc to get the medicine back up to the full dose again. I stayed there for anouther 9 months and decided I wanted off the medicine, it was making me tired, fat, and i felt like I was in hell. Decreased the dose to 5mg and felt great for a while, then I was feeling tired, worn out and wanted the med again at full dose, but my doctor would not let me. I went a little crazy over the next 2 years, finding that I would worry alot and imagine things. Tried some other anti-psychotics, but none of them could take the place or fill the void of zyprexa. They all made me feel worse and I was not feeling happy at all. Only zyprexa has this amazing calming, refreshing, happy feel to it. All the other AP did not work except zp. I asociate zyprexa with saine, not zyprexa insane. Eventualy I went back on the full dose again but it was not the same and I would not feel good at higher doses anymore but I was insane at lower doses. Is it my imagination. I realy liked the effects of zyprexa the first pill I took, it made me feel realy good and I wanted to take it, when I saw the price of it i realy wanted to take it. So for the last 2 years or so I've been on many different doses I'm starting to think changing the dose and taking it as needed is best. Currently I take 5mg again with abilify, so far I have not gone crazy, but its only been 3 weeks and I don't think I can get all the way off the zyprexa, because you feel fine for a while and then desperatly want it back again.
Posted by Sebastian on January 1, 2007, at 19:44:07
In reply to Re: Taking a poll - have you failed to quit Zyprexa? » kotsunega, posted by Quintal on January 1, 2007, at 12:52:34
I tried this and had the worst sleep ever. Very bad nightmares, couldn't function. Like always happens when I stop it except worse. I had a nightmare that I would never be able to get more zyprexa.
Posted by Quintal on January 1, 2007, at 19:52:47
In reply to Re: remeron to substitute zyprexa, ha » Quintal, posted by Sebastian on January 1, 2007, at 19:44:07
>I had a nightmare that I would never be able to get more zyprexa.
:-)
Posted by Phillipa on January 1, 2007, at 19:58:17
In reply to Re: remeron to substitute zyprexa, ha » Quintal, posted by Sebastian on January 1, 2007, at 19:44:07
Sebastian not to be mean but glad I didn't take your advise you know what I mean. We need to e-mail again. Love Phillipa
Posted by Sebastian on January 1, 2007, at 20:00:12
In reply to Re: Are there any positives about Zyprexa?, posted by UgottaHaveHope on January 1, 2007, at 15:59:08
zyprexa is the best drug I ever took. It is the only one that made me saine for years and still does. risperdal made me holucinate and stiff as a board, could not move. geodon was too weak and did nothing for me. Abilify I'm trying again but with the zyprexa. I don't want to stop zyprexa except for one thing, it may be giving me diabeties. I hope that half the dose will work and get blood sugar under control.
Posted by Sebastian on January 1, 2007, at 20:10:33
In reply to Re: remeron to substitute zyprexa, ha » Sebastian, posted by Phillipa on January 1, 2007, at 19:58:17
I still think that zyprexa is the best known medicine to man. They just need to get the diabeties out of it. I'm at half the dose now and losing wieght most of the time now blood sugar is ok. what is it with low dose AP's working best.
Posted by Guy on January 1, 2007, at 21:14:43
In reply to Taking a poll - have you failed to quit Zyprexa?, posted by kotsunega on January 1, 2007, at 0:44:26
In the past I have quit 10 mg Z cold turkey after taking it for months on end. I did this by switching to 100 mg doxepin which helped me avoid the killer rebound insomnia. Getting off doxepin was no easy task either...seven days with absolutely no sleep and anxiety beyond belief. I finally switched to Remeron and then managed to wean off that. However, after several months of really bad panic and anxiety, I'm back on 5 mg Z along with 1 mg clonazepam. Yes, I'm calmer and I'm sleeping again, but I hate the constipation, lethargy and impotence. God how I wish I had never started meds!
Posted by UgottaHaveHope on January 1, 2007, at 21:16:32
In reply to Re: remeron to substitute zyprexa, ha » Phillipa, posted by Sebastian on January 1, 2007, at 20:10:33
Does anyone have any experiences with Depakote? Do you think it would help with anxiety like Seroquel? Does it have bad side effects? Thanks, Michael
Posted by Quintal on January 1, 2007, at 21:25:14
In reply to Re: Is Depakote just as dangerous?, posted by UgottaHaveHope on January 1, 2007, at 21:16:32
I tried Depakote after being diagnosed with bipolar years ago. It made me feel flat and empty - spaced out. After a few weeks I started to notice loads of hair at the bottom of the shower and I decided to quit it after that. It can also cause hormonal disturbances in women. Benzos are probably safer and have fewer side effects long term.
Q
Posted by med_empowered on January 1, 2007, at 22:18:36
In reply to Re: Is Depakote just as dangerous? » UgottaHaveHope, posted by Quintal on January 1, 2007, at 21:25:14
Depakote sucks. If you're very bipolar or have schizoaffective, I imagine you might be in a situation where the risks:benefits ratio worked out well. Aside from those cases...I think you may be better off on a benzo (some of which can do double duty as mood stabilizers) or..anything not depakote.
good luck.
Posted by linkadge on January 2, 2007, at 16:55:46
In reply to Re: Is Depakote just as dangerous?, posted by med_empowered on January 1, 2007, at 22:18:36
I really liked depakote. I was scared off by the side effects and risks (liver dammage, pancreatis etc). I was discouraged by the side effects as this medication helped a lot.
I personally felt it had more antidepressant effect than tegretol/trileptal.
Linkadge
Posted by laima on January 2, 2007, at 18:16:08
In reply to Re: Is Depakote just as dangerous?, posted by linkadge on January 2, 2007, at 16:55:46
Linkadge, what sorts of side effects did you get with depakote, and did you experience ones bad enough to make you quit? Or did you quit due to risks? One of my doctor's colleagues has been studying depakote for depression, and they are really excited and gung-ho about it. (Not sure if the study has been published yet or not.)
Posted by linkadge on January 2, 2007, at 19:46:30
In reply to Re: Is Depakote just as dangerous? » linkadge, posted by laima on January 2, 2007, at 18:16:08
Depakote was one of the most tollerable meds I have ever taken.
More tollerable than SSRi's, APS, etc.
I just don't want liver dammage or pancreatis.
Supposedly liver dammage can happen with this one in the absense of normal liver function tests.
Linkadge
Posted by MidnightBlue on January 2, 2007, at 20:35:25
In reply to Re: Is Depakote just as dangerous?, posted by linkadge on January 2, 2007, at 19:46:30
I took 1000 mg of Depakote for about 10 years. NO liver damage.
MB
Posted by Phillipa on January 2, 2007, at 20:58:47
In reply to Re: Is Depakote just as dangerous? » linkadge, posted by MidnightBlue on January 2, 2007, at 20:35:25
l0 years wow that's a long time and it worked? Love Phillipa
Posted by MidnightBlue on January 2, 2007, at 22:43:54
In reply to Re: Is Depakote just as dangerous? » MidnightBlue, posted by Phillipa on January 2, 2007, at 20:58:47
I didn't say it worked. It helped some to lessen migraine headaches. Did NOT help with depression. Might have helped me sleep a bit better.
MB
Posted by tessellated on January 4, 2007, at 15:42:44
In reply to Re: Is Depakote just as dangerous? » Phillipa, posted by MidnightBlue on January 2, 2007, at 22:43:54
Curiously Valproic acid is an inhibitor of the enzyme histone deacetylase 1 (HDAC1). HDAC1 is needed for HIV to remain in infected cells. A study published in August 2005 revealed that patients treated with valproic acid in addition to highly active antiretroviral therapy (HAART) showed a 75% reduction in latent HIV infection. This may one day lead to a cure for HIV and AIDS.
wow!
Posted by linkadge on January 5, 2007, at 19:40:36
In reply to Re: Is Depakote-BONUS potential HIV inhibitor, posted by tessellated on January 4, 2007, at 15:42:44
I would consider trying depakote again, but I don't know how to quantify the new lable change including pancreatis.
Linkadge
Posted by yxibow on January 9, 2007, at 2:43:11
In reply to Re: Is Depakote just as dangerous?, posted by linkadge on January 2, 2007, at 19:46:30
> Depakote was one of the most tollerable meds I have ever taken.
>
> More tollerable than SSRi's, APS, etc.
>
> I just don't want liver dammage or pancreatis.
>
> Supposedly liver dammage can happen with this one in the absense of normal liver function tests.
>
>
> LinkadgeI'd concur on its tolerability. What it did for me wasn't really clear, I think we tried it twice, I dont recall at what dosage. But it was just another AED to try on the laundry list, I don't tend in the bipolar spectrum.
The organ monitoring I don't know about; I think its prudent to blood monitor any medication from time to time that has a significant known problem, especially on polypharmacy.
-- Jay
Posted by Sebastian on January 10, 2007, at 19:22:50
In reply to Re: Is Depakote just as dangerous?, posted by linkadge on January 2, 2007, at 16:55:46
I didn't like Depakote. When I read about the liver side-effects I said no. But I realy didn't think it helped me, or was helping me. I told my doc that and he took me off it. I didn't miss it eather.
This is the end of the thread.
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