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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by saturn on December 5, 2006, at 17:59:53
WB seems to have a reputation of being stimulating. Is it also very stimulating *peripherally*...compared to say ssri's, provigil, amphetamine. I've never tried provigil but have tried ssri's and amphetamine and cannot tolerate either (cardiovascular side effects).I'm guessing if I can't tolerate an ssri from this standpoint wellbutrin would probably be a bad bet??? Thanks for any info/thoughts.
Posted by linkadge on December 5, 2006, at 19:28:20
In reply to How peripherally stimulating is Wellbutrin?, posted by saturn on December 5, 2006, at 17:59:53
I'd be interested in responces too, as I have never tried bupropion.
Linkadge
Posted by tensor on December 6, 2006, at 6:55:47
In reply to How peripherally stimulating is Wellbutrin?, posted by saturn on December 5, 2006, at 17:59:53
Posted by Quintal on December 6, 2006, at 17:15:02
In reply to How peripherally stimulating is Wellbutrin?, posted by saturn on December 5, 2006, at 17:59:53
I had a rapid heart beat, shakiness etc on bupropion. The effect was similar to that I get from smoking a cigarette (minus the nausea).
Q
Posted by laima on December 7, 2006, at 19:36:33
In reply to Re: How peripherally stimulating is Wellbutrin? » saturn, posted by Quintal on December 6, 2006, at 17:15:02
What do you mean by "peripherally stimulating"? I used wellbutrin for awhile, I'd love to contribute if I can. I thought it was a pretty good antidepressent. The reason I discontinued it was because I was experiencing a lot of anxiety- though much of that could be attributed to my life circumstances at the time as well as to the other two medications I was using.
Posted by psychobot5000 on December 7, 2006, at 21:50:36
In reply to Re: How peripherally stimulating is Wellbutrin?, posted by laima on December 7, 2006, at 19:36:33
I also experienced a lot of anxiety on wellbutrin, as well as insomnia, but as for peripheral stimulation (by which I presume you mean heart-rate and pressor effects? I've never been entirely clear on the term 'peripheral stimulation...'), I don't recall having any.
I get tachycardia and BP effects on almost any tricyclic, and I get some modest s/e from stimulants, for comparison.
I don't think it has a bad reputation in that regard--physicians mostly worry about the seizures, as far as I can tell.
Posted by dreamann on December 12, 2006, at 1:17:54
In reply to would be nice to know (nm) » saturn, posted by tensor on December 6, 2006, at 6:55:47
Could anyone else comment. Ive had to stop taking amphetamines, strattera, provigil, and oral selegiline because of peripheral effect such as increased heart rate, blood pressure spikes, palpitation etc. Could anyone else compare wellbutrins effects with one of the above drugs.
Thanks
Posted by saturn on December 12, 2006, at 5:17:03
In reply to Re: How peripherally stimulating is Wellbutrin? » saturn, posted by Quintal on December 6, 2006, at 17:15:02
Thanks Q
Posted by saturn on December 12, 2006, at 5:19:42
In reply to Re: How peripherally stimulating is Wellbutrin?, posted by laima on December 7, 2006, at 19:36:33
>
> What do you mean by "peripherally stimulating"?Hi Laimia,
I primarily mean increased heart rate, force of contraction and blood pressure...but I guess also sweatiness and shakiness/jitteriness would count too. Thanks for asking and the info. Peace...Saturn.
I used wellbutrin for awhile, I'd love to contribute if I can. I thought it was a pretty good antidepressent. The reason I discontinued it was because I was experiencing a lot of anxiety- though much of that could be attributed to my life circumstances at the time as well as to the other two medications I was using.
Posted by saturn on December 12, 2006, at 5:22:04
In reply to Re: How peripherally stimulating is Wellbutrin?, posted by psychobot5000 on December 7, 2006, at 21:50:36
>>peripheral stimulation (by which I presume you mean heart-rate and pressor effects?
Hi psychobot5000,
Yes, that's what I mean (as opposed to say anxiety as "central stimulation". Guess I should be more clear. Thanks for the info. Peace...Saturn.
> I get tachycardia and BP effects on almost any tricyclic, and I get some modest s/e from stimulants, for comparison.
>
> I don't think it has a bad reputation in that regard--physicians mostly worry about the seizures, as far as I can tell.
Posted by saturn on December 12, 2006, at 5:26:35
In reply to Re: would be nice to know, posted by dreamann on December 12, 2006, at 1:17:54
>>> ...I've had to stop taking amphetamines, strattera, provigil, and oral selegiline because of peripheral effect such as increased heart rate, blood pressure spikes, palpitation etc. Could anyone else compare wellbutrins effects with one of the above drugs.
^ ^ the story of my life! ^ ^
Unfortunately, dreamann, WB does seem to be pretty activating in this regard. Of course as I'm sure you're aware YMMV...but given my history w/ meds I'm not willing to try WB.
May I ask you about your experience with Provigil? Thanks...Peace...Saturn.
Posted by dreamann on December 12, 2006, at 14:55:06
In reply to Re: would be nice to know » dreamann, posted by saturn on December 12, 2006, at 5:26:35
well not much to tell, this was the most recent one I tried. I took it for about 4 days before quiting. As usual by the end I had to down magnesium supplements which seems to counter act the palpitations and jitters etc. Jitters were worse a few hours after drug wore off. Didn't notice as much benefit either compared with amphetamines and the selegiline. I Did think it was more effective than strattera which had almost no beneficial effects for me. Just wondering if others with these side effects have been diagnosed with mitral valve prolapse or other heart things?
Posted by saturn on December 12, 2006, at 17:08:56
In reply to Re: would be nice to know saturn, posted by dreamann on December 12, 2006, at 14:55:06
>>>well not much to tell, this was the most recent one I tried. I took it for about 4 days before quiting. As usual by the end I had to down magnesium supplements which seems to counter act the palpitations and jitters etc. Jitters were worse a few hours after drug wore off. Didn't notice as much benefit either compared with amphetamines and the selegiline. I Did think it was more effective than strattera which had almost no beneficial effects for me.
Thanks for sharing this experience--I fear I'd have a similiar one. Sorry to hear it didn't work out for you.
>>>Just wondering if others with these side effects have been diagnosed with mitral valve prolapse or other heart things?
I may have a very mild MVP, but without any regurgitation (FYI I've seen several cardiologists about this due to my med responses and a few said I have no MVP and a few said it is at most very mild, but still without any significant regurgitation). I am otherwise pretty healthy and actually rather athletic.I assume your babblemail is intentionally turned-off, but if not I'd be interested in chatting sometime about your trials as I can't for the life of me seem to tolerate an ADHD med--which I think is similiar to your situation also. Peace...Saturn.
Posted by tessellated on December 13, 2006, at 13:32:53
In reply to Re: How peripherally stimulating is Wellbutrin? » psychobot5000, posted by saturn on December 12, 2006, at 5:22:04
Uhmm,
So i've had several wellbutrin trials.
It, provigil, parnate, and tianeptine, are the only effective AD's in my book. Not including the stronger stims/benzo's etc.
At one point I tried to abuse wellbutrin, high doses like 900-1200, crushing it, insufflating it (yeach), and at those doses absolutely felt like ritalin. Less pleasant perhaps. Moderate peripheral stim. Regardless, days later (after i had used my last xanax), had not slept, was extremely stressed, I had a seizure. i had a big *ss med bill, and suspended drivers liscence.So my thinking is now using only 150mg daily, that yes as a chem wellbutrin would have peripheral effects, but mostly at high doses. (At 150mg/day, it feels a bit like a extended release libido enhancing cup of tea..) But I wouldn't touch anything higher than 300mg wellbutrin as the seizure threshold drops and more than 1/1000 peeps will experience seizures.
Wellbutrin even at low doses synergizes with other stims dramatically, even caffeine, with which I can feel moderately increased heart rate.
I know a number of pdocs that use wellbutrin and provigil safely.
I found wellbutrin and parnate quite effective, but was a bit worried as over time peripheral stim felt a bit excessive. Was great AD otherwise though.l8
Posted by Reggie BoStar on December 14, 2006, at 20:48:21
In reply to How peripherally stimulating is Wellbutrin?, posted by saturn on December 5, 2006, at 17:59:53
6 months ago I was on Wellbutrin 450mg/day. It caused a LOT of anxiety, panic attacks, pounding heart. I was taken completely off it and my dose of Cymbalta was increased from 60mg/day to 90mg/day.
Then the higher dose of Cymbalta started getting to me. It was too sedating and soon I had a really bad attack of severe depression. Last week, the Cymbalta was lowered back to 60mg/day and I was put on a lower dose of Wellbutrin than the last time (200mg/day).
The first few days was OK. It was energizing but in a good way and it got me back on my feet after the severe depression.
Now, unfortunately, the anxiety is returning and with it the depression. It looks as though Wellbutrin is just too stimulating for me even at the smaller dose.
I've never been on it long enough to know whether or not its antidepressant effects will work on me. But since nothing else has, I doubt it.
This is the end of the thread.
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